Abstract: The subject invention pertains to methods and devices for generating mature oocytes from immature oocytes and improving oocyte quality for improved success of assistant reproductive technology (ART). The methods include the use of tunneling nanotube-forming cells and oocytes, wherein the tunneling nanotube-forming cells transfer autologous genomic materials, biomolecules and cellular components to the oocytes. The devices of the invention include microfluidic device to improve the efficiency of the transfer of biomolecules and cellular components between tunneling nanotube-forming cells and oocytes.

Abstract: The subject invention pertains to methods and devices for generating mature oocytes from immature oocytes and improving oocyte quality for improved success of assistant reproductive technology (ART). The methods include the use of tunneling nanotube-forming cells and oocytes, wherein the tunneling nanotube-forming cells transfer autologous genomic materials, biomolecules and cellular components to the oocytes. The devices of the invention include microfluidic device to improve the efficiency of the transfer of biomolecules and cellular components between tunneling nanotube-forming cells and oocytes.

Abstract: According to embodiments of the invention, systems and methods are provided for capturing nucleotide sequence and providing associated modification snapshots with timestamps. The system and/or method are adapted to receive a sample containing a genome sequence from an individual or an organism (hereinafter collectively referred to as a “subject”) that uses the genome for encoding DNA or RNA. The genome sequence is then identified and stored in a database, for access at a later time. Multiple samples from multiple individuals may be taken, analyzed, and compare via the provided invention. Moreover, genetic as well as non-genetic information may be determined and stored in the database. Such information may include data relating to phenotypic features and clinical biological data.