Abstract: The instant invention relates to liquid membrane capsule system (LMCS) which are made resistant to coalescence by means of an irreversible coating material present in the suspension phase. LMCS having this irreversible coating material are stable (i.e. resist coalescence) over relatively long periods of time with little or no applied agitation. These irreversibly coated LMCS can be pumped for long periods, are resistant to bile, pancreatin and solid matter and maintain their initial size distribution.The instant invention relates to methods of preparing the irreversibly coated LMCS.The LMCS of the instant invention exhibit resistance to rupture during pumping and passage over packing materials, such as glass beads or charcoal, thus making them of use in medical treatment processes such as renal dialysis and in the equipment used for such processes.

Abstract: The present invention relates to liquid membrane capsules which rupture when contacted with biliary or pancreatic secretions in the intestine thereby releasing their contents in the intestine so the contents become fully available for the treatment of disease at that location in the animal or patient. Particularly, the rupturable liquid membrane capsules containing urease are used for the treatment of chronic uremia. The liquid membrane capsules comprise an internal aqueous phase which contains an oil insoluble medicinal of choice, some complexing agent, dietary supplement or enzyme particularly suited for the intended treatment. This internal aqueous and oil insoluble phase is encapsulated in a nonaqueous external phase comprising a biologically inert oil component, and a material which will complex with the biliary and/or pancreatic secretions in the intestine thereby causing the rupture of the external phase resulting in the release of the internal phase in the intestine.