Patents by Inventor Tina Giese

Tina Giese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-TRANSFERRIN RECEPTOR FUSION PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20240148866
    Abstract: Certain embodiments provide a fusion protein comprising an iduronate 2-sulfatase (IDS) amino acid sequence, an IDS variant amino acid sequence, or a catalytically active fragment thereof; and an anti-transferrin receptor (TfR) antibody as described herein, as well as methods of use thereof.
    Type: Application
    Filed: February 11, 2022
    Publication date: May 9, 2024
    Applicant: DENALI THERAPEUTICS INC.
    Inventors: Annie ARGUELLO, Tina GIESE, Gunasekaran KANNAN, Mihalis S. KARIOLIS, Cathal S. MAHON, Junhua WANG
  • FUSION PROTEINS COMPRISING SULFOGLUCOSAMINE SULFOHYDROLASE ENZYMES AND METHODS THEREOF
    Publication number: 20240150736
    Abstract: Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise sulfoglucosamine sulfohydrolase (SGSH) enzyme-Fc fusion polypeptides. Certain embodiments also provide methods of using such proteins to treat Sanfilippo syndrome A.
    Type: Application
    Filed: January 12, 2024
    Publication date: May 9, 2024
    Applicant: DENALI THERAPEUTICS INC.
    Inventors: Tina GIESE, Gunasekaran KANNAN, Mihalis S. KARIOLIS, Cathal S. MAHON
  • Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof
    Patent number: 11884944
    Abstract: Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise sulfoglucosamine sulfohydrolase (SGSH) enzyme-Fc fusion polypeptides. Certain embodiments also provide methods of using such proteins to treat Sanfilippo syndrome A.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: January 30, 2024
    Assignee: DENALI THERAPEUTICS INC.
    Inventors: Tina Giese, Gunasekaran Kannan, Mihalis S. Kariolis, Cathal S. Mahon
  • Enhanced drill bit profile for use in HDD
    Patent number: 11808088
    Abstract: A new horizontal directional drilling (HDD) bit comprising a bit body is provided with illustrated embodiments including a flat bit design and a cobble bit design. Cutter teeth may be cut (e.g. formed or machined) into the base steel material of the bit body. Additionally, a broken edge profile may be generated to avoid sharp corners for better receipt of hard facing material such as laser clad beads that may be applied in higher wear regions.
    Type: Grant
    Filed: July 20, 2021
    Date of Patent: November 7, 2023
    Assignee: Kondex Corporation
    Inventors: Mark More, James Wessing, Tina Giese, Casey Placek
  • FUSION PROTEINS COMPRISING SULFOGLUCOSAMINE SULFOHYDROLASE ENZYMES AND METHODS THEREOF
    Publication number: 20230062800
    Abstract: Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise sulfoglucosamine sulfohydrolase (SGSH) enzyme-Fc fusion polypeptides. Certain embodiments also provide methods of using such proteins to treat Sanfilippo syndrome A.
    Type: Application
    Filed: June 30, 2022
    Publication date: March 2, 2023
    Applicant: DENALI THERAPEUTICS INC.
    Inventors: Tina GIESE, Gunasekaran KANNAN, Mihalis KARIOLIS, Cathal MAHON
  • Wear enhancement of HDD drill string components
    Patent number: 11525313
    Abstract: A hard facing is preferably accomplished with laser clad beads applied to horizontal directional drilling (HDD) component(s). These components may be subject to recirculating fluid regions associated to stepped geometries along a drill string, including various drill string coupling members. For example, laser cladding can be applied to a step region of the sonar housing and starter rod. A method applies a hard face coating such as laser cladding or other suitable hard facing in areas of tight geometric tolerances.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: December 13, 2022
    Assignee: Kondex Corporation
    Inventors: Mark More, Casey Placek, Tina Giese, James Wessing
  • FORMULATIONS OF PROTEIN MOLECULES COMPRISING IDURONATE 2-SULFATASE
    Publication number: 20220184186
    Abstract: Certain embodiments provide a pharmaceutical composition comprising: a protein molecule comprising an ERT enzyme-Fc fusion polypeptide and a modified Fc polypeptide; a buffer; an isotonicity agent; a surfactant; and a stabilizer; wherein the pH of the pharmaceutical composition is about 5.5 to 7.0, as well as methods of use thereof.
    Type: Application
    Filed: April 3, 2020
    Publication date: June 16, 2022
    Applicant: DENALI THERAPEUTICS INC.
    Inventors: Dana ANDERSEN, Adam CATHERMAN, Tina GIESE, Gunasekaran KANNAN, Mihalis KARIOLIS, Cathal MAHON, Ankit PATEL
  • ENHANCED DRILL BIT PROFILE FOR USE IN HDD
    Publication number: 20220025713
    Abstract: A new horizontal directional drilling (HDD) bit comprising a bit body is provided with illustrated embodiments including a flat bit design and a cobble bit design. Cutter teeth may be cut (e.g. formed or machined) into the base steel material of the bit body. Additionally, a broken edge profile may be generated to avoid sharp corners for better receipt of hard facing material such as laser clad beads that may be applied in higher wear regions.
    Type: Application
    Filed: July 20, 2021
    Publication date: January 27, 2022
    Applicant: Kondex Corporation
    Inventors: Mark More, James Wessing, Tina Giese, Casey Placek
  • WEAR ENHANCEMENT OF HDD DRILL STRING COMPONENTS
    Publication number: 20210156206
    Abstract: A hard facing is preferably accomplished with laser clad beads applied to horizontal directional drilling (HDD) component(s). These components may be subject to recirculating fluid regions associated to stepped geometries along a drill string, including various drill string coupling members. For example, laser cladding can be applied to a step region of the sonar housing and starter rod. A method applies a hard face coating such as laser cladding or other suitable hard facing in areas of tight geometric tolerances.
    Type: Application
    Filed: November 18, 2020
    Publication date: May 27, 2021
    Applicant: Kondex Corporation
    Inventors: Mark More, Casey Placek, Tina Giese, James Wessing