Abstract: Provided are methods and articles of manufacture for use with cell therapy for the treatment of diseases or conditions, e.g., cancer, including for predicting and treating a toxicity. In some embodiments, the toxicity is a neurotoxicity or cytokine release syndrome (CRS), such as a severe neurotoxicity or a severe CRS. The methods generally involve detecting a marker by assaying a biological sample from a subject that is a candidate for treatment, optionally with a cell therapy, to determine if the subject is at risk for developing the toxicity, such as neurotoxicity or CRS or severe neurotoxicity or severe CRS. In some embodiments, the methods and articles of manufacture further includes a regent for assaying the biological sample and instructions for determining the percentage or number of cells positive for the marker in the biological sample.

Abstract: An e-mail system is disclosed that overcomes many deficiencies of, but is backward compatible with, existing e-mail systems. An exemplary method for communicating e-mail messages comprises receiving, at a server system, an original e-mail message associated with a unique message ID that is assigned by the server system. The method further comprises storing a distribution list associated with the unique message ID and a thread participation status indicator for each of the one or more recipients, and, in response to an opt-out request received from one of the recipients, updating the distribution list to thereby produce a modified distribution list that does not include the requesting recipient. The method further comprises receiving a reply e-mail message in the same thread, and sending the reply e-mail message based on the modified distribution list such that the reply e-mail message is not sent to the requesting recipient.

Abstract: An e-mail system is disclosed that overcomes many deficiencies of, but is backward compatible with, existing e-mail systems. An exemplary method for communicating e-mail messages comprises receiving, at a server system, an original e-mail message associated with a unique message ID that is assigned by the server system. The method further comprises storing a distribution list associated with the unique message ID and a thread participation status indicator for each of the one or more recipients, and, in response to an opt-out request received from one of the recipients, updating the distribution list to thereby produce a modified distribution list that does not include the requesting recipient. The method further comprises receiving a reply e-mail message in the same thread, and sending the reply e-mail message based on the modified distribution list such that the reply e-mail message is not sent to the requesting recipient.