Patents by Inventor Ting-Yu Shih
Ting-Yu Shih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11752238Abstract: Disclosed are compositions and related methods of recapitulating bone marrow stroma using scaffold materials (e.g., a porous alginate hydrogel scaffold) containing one or more cellular differentiation factors, and one or more growth factors. Such methods and compositions promote the formation of an ectopic nodule or site that can improve transplanted cell engraftment and selectively drive the development of lymphocytes and the reconstitution of the adaptive immunity after hematopoietic stem cell transplant.Type: GrantFiled: February 6, 2017Date of Patent: September 12, 2023Assignees: President and Fellows of Harvard College, The General Hospital CorporationInventors: Nisarg J. Shah, Ting-Yu Shih, Angelo Mao, David J. Mooney, David T. Scadden
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Patent number: 11629213Abstract: A graft polymer is provided, which includes a polymer backbone with a plurality of hydroxy groups, protection group modified histidine grafted onto the side of the polymer backbone, and hydrophilic polymer having terminal reactive group grafted onto the side of the polymer backbone. The graft polymer coating can be applied to metal material to form a composite material, which can be implanted into an organism to reduce adhesion problems.Type: GrantFiled: December 24, 2020Date of Patent: April 18, 2023Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Ting-Yu Shih, Chia-Chun Wang, Lu-Chih Wang, Yuan-Kun Yu, Shu-Fang Chiang, Yi-Ting Hsieh, Yu-Chun Liu, Jing-Wen Tang
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Patent number: 11246822Abstract: A method for skin care and/or maintenance including applying or administering a preparation to a subject is provided. The preparation includes a biomedical composition, and the biomedical composition includes an effective amount of micelle, wherein the micelle includes a hyaluronic acid and/or a derivative thereof and a modified histidine. The modified histidine is grafted to at least one primary hydroxyl group of the hyaluronic acid and/or the derivative thereof, and a graft ratio of the modified histidine is 1-100%. Moreover, the hyaluronic acid and/or the derivative thereof and the modified histidine form the micelle on a weight percentage of 0.2-300:1.Type: GrantFiled: December 30, 2019Date of Patent: February 15, 2022Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Ting-Yu Shih, Lu-Chih Wang, Yuan-Kun Yu, Yi-Ting Hsieh, Yu-Chun Liu, Jing-Wen Tang
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Publication number: 20210198409Abstract: A graft polymer is provided, which includes a polymer backbone with a plurality of hydroxy groups, protection group modified histidine grafted onto the side of the polymer backbone, and hydrophilic polymer having terminal reactive group grafted onto the side of the polymer backbone. The graft polymer coating can be applied to metal material to form a composite material, which can be implanted into an organism to reduce adhesion problems.Type: ApplicationFiled: December 24, 2020Publication date: July 1, 2021Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Ting-Yu SHIH, Chia-Chun WANG, Lu-Chih WANG, Yuan-Kun YU, Shu-Fang CHIANG, Yi-Ting HSIEH, Yu-Chun LIU, Jing-Wen TANG
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Publication number: 20200375873Abstract: A method for skin care and/or maintenance including applying or administering a preparation to a subject is provided. The preparation includes a biomedical composition, and the biomedical composition includes an effective amount of micelle, wherein the micelle includes a hyaluronic acid and/or a derivative thereof and a modified histidine. The modified histidine is grafted to at least one primary hydroxyl group of the hyaluronic acid and/or the derivative thereof, and a graft ratio of the modified histidine is 1-100%. Moreover, the hyaluronic acid and/or the derivative thereof and the modified histidine form the micelle on a weight percentage of 0.2-300:1.Type: ApplicationFiled: December 30, 2019Publication date: December 3, 2020Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Ting-Yu SHIH, Lu-Chih WANG, Yuan-Kun YU, Yi-Ting HSIEH, Yu-Chun LIU, Jing-Wen TANG
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Publication number: 20200206333Abstract: Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic stem and progenitor cells. It is a devastating disease with a poor prognosis and an average 5-year survival rate of about 30%. Disclosed herein are composition and methods for treating leukemia with a biomaterial comprising a polymer scaffold, a dendritic cell activating factor, a dendritic cell recruitment factor, and at least one leukemia antigen. The biomaterial-based vaccine disclosed herein promotes a potent, durable and transferable immune response against acute myeloid leukemia to prevent cell engraftment and synergizes with chemotherapy to prevent relapse.Type: ApplicationFiled: December 9, 2019Publication date: July 2, 2020Applicants: President and Fellows of Harvard College, The General Hospital CorporationInventors: Nisarg J. Shah, Ting-Yu Shih, Angelo S. Mao, David J. Mooney, David T. Scadden
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Publication number: 20190216910Abstract: The provided herein are methods and compositions for eliciting an immune response to an antigen, such as cancer and microbial antigens.Type: ApplicationFiled: January 31, 2019Publication date: July 18, 2019Inventors: David J. Mooney, W. Aileen Li, Omar Abdel-Rahman Ali, Ting-Yu Shih
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Publication number: 20190060525Abstract: Disclosed are compositions and related methods of recapitulating bone marrow stroma using scaffold materials (e.g., a porous alginate hydrogel scaffold) containing one or more cellular differentiation factors, and one or more growth factors. Such methods and compositions promote the formation of an ectopic nodule or site that can improve transplanted cell engraftment and selectively drive the development of lymphocytes and the reconstitution of the adaptive immunity after hematopoietic stem cell transplant.Type: ApplicationFiled: February 6, 2017Publication date: February 28, 2019Inventors: Nisarg J. Shah, Ting-Yu Shih, Angelo Mao, David J. Mooney, David T. Scadden
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Patent number: 10012646Abstract: A sensing chip including a substrate, a plurality of metal nanostructures, a first surface modified layer and a second surface modified layer is provided. The metal nanostructures are disposed on the substrate. The first surface modified layer is disposed on a surface of the metal nanostructures, wherein the first surface modified layer includes a plurality of thiol group-containing molecules. The second surface modified layer is disposed on a surface of the substrate, wherein the second surface modified layer includes a plurality of silyl group-containing molecules.Type: GrantFiled: December 30, 2015Date of Patent: July 3, 2018Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Ding-Zheng Lin, Feng-Sheng Kao, Ting-Yu Shih, Ping-Chen Chen, Jen-You Chu
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Patent number: 9737607Abstract: A polymer and a pharmaceutical composition employing the same are disclosed. The polymer includes a first repeating unit, a second repeating unit, and a third repeating unit. In particular, the first repeating unit is the second repeating unit is wherein R1 is C1-6 alkyl group; and the third repeating unit is wherein X is and Y is a hydrophilic polymeric moiety.Type: GrantFiled: December 24, 2015Date of Patent: August 22, 2017Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jui-Hsiang Chen, Yu-Hua Chen, Chia-Chen Tsai, Tse-Min Teng, Ting-Yu Shih, Chia-Chun Wang, Chia-wei Hong, Jennline Sheu, Hui-Ling Cheng, Shu-Feng Chen, Hung-Jui Huang, Shu-Ling Wang
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Publication number: 20170184584Abstract: A sensing chip including a substrate, a plurality of metal nanostructures, a first surface modified layer and a second surface modified layer is provided. The metal nanostructures are disposed on the substrate. The first surface modified layer is disposed on a surface of the metal nanostructures, wherein the first surface modified layer includes a plurality of thiol group-containing molecules. The second surface modified layer is disposed on a surface of the substrate, wherein the second surface modified layer includes a plurality of silyl group-containing molecules.Type: ApplicationFiled: December 30, 2015Publication date: June 29, 2017Inventors: Ding-Zheng Lin, Feng-Sheng Kao, Ting-Yu Shih, Ping-Chen Chen, Jen-You Chu
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Publication number: 20160184437Abstract: A polymer and a pharmaceutical composition employing the same are disclosed. The polymer includes a first repeating unit, a second repeating unit, and a third repeating unit. In particular, the first repeating unit is the second repeating unit is wherein R1 is C1-6 alkyl group; and the third repeating unit is wherein X is and Y is a hydrophilic polymeric moiety.Type: ApplicationFiled: December 24, 2015Publication date: June 30, 2016Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jui-Hsiang Chen, Yu-Hua Chen, Chia-Chen Tsai, Tse-Min Teng, Ting-Yu Shih, Chia-Chun Wang, Chia-wei Hong, Jennline Sheu, Hui-Ling Cheng, Shu-Feng Chen, Hung-Jui Huang, Shu-Ling Wang
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Publication number: 20160113905Abstract: A polymer composition including a polymer having a hydroxyl group and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group. A polymer material is also provided, including a polymer composition which includes a polymer having a hydroxyl group, and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group.Type: ApplicationFiled: December 22, 2015Publication date: April 28, 2016Inventors: Ting-Yu Shih, Tse-Min Teng, Chia-Chun Wang, Yu-Hua Chen, Jui-Hsiang Chen, Mei-Ju Yang, Shu-Fang Chiang, Yen-Chun Chen, Chia-Ni Chang
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Patent number: 8968765Abstract: The present disclosure provides a brush polymer, including: a linear polymer main chain; and brush structural side chains, including: a hydrophobic molecular branch, and a hydrophilic molecular branch and/or an anti-biofilm/or an anti-microbial molecular branch, wherein the linear polymer main chain is conjugated to the side chains by covalent bonds formed between a hydroxyl group and a reactive functional group, wherein the reactive functional group includes: isocyanate, carboxyl, or epoxy. The present disclosure also provides a medical application of the brush polymer.Type: GrantFiled: August 27, 2012Date of Patent: March 3, 2015Assignee: Industrial Technology Research InstituteInventors: Jui-Hsiang Chen, Jean-Dean Yang, Yu-Hua Chen, Ting-Yu Shih, Chia-wei Hong, Chao-Chen Tien
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Publication number: 20140186415Abstract: A polymer composition including a polymer having a hydroxyl group and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group. A polymer material is also provided, including a polymer composition which includes a polymer having a hydroxyl group, and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group.Type: ApplicationFiled: December 18, 2013Publication date: July 3, 2014Applicant: Industrial Technology Research InstituteInventors: Ting-Yu SHIH, Tse-Min TENG, Chia-Chun WANG, Yu-Hua CHEN, Jui-Hsiang CHEN, Mei-Ju YANG, Shu-Fang CHIANG, Yen-Chun CHEN, Chia-Ni CHANG
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Publication number: 20130149542Abstract: The present disclosure provides a brush polymer, including: a linear polymer main chain; and brush structural side chains, including: a hydrophobic molecular branch, and a hydrophilic molecular branch and/or an anti-biofilm/or an anti-microbial molecular branch, wherein the linear polymer main chain is conjugated to the side chains by covalent bonds formed between a hydroxyl group and a reactive functional group, wherein the reactive functional group includes: isocyanate, carboxyl, or epoxy. The present disclosure also provides a medical application of the brush polymer.Type: ApplicationFiled: August 27, 2012Publication date: June 13, 2013Inventors: Jui-Hsiang CHEN, Jean-Dean Yang, Yu-Hua Chen, Ting-Yu Shih, Chia-Wei Hong, Chao-Chen Tien
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Publication number: 20120150078Abstract: A medical dressing is provided. The medical dressing includes a first and a second woven layers respectively having a fiber of polyurethane or a yarn of polyurethane; and a plurality of linear support portions woven between the first and second woven layers.Type: ApplicationFiled: February 23, 2011Publication date: June 14, 2012Inventors: Jui-Hsiang CHEN, Yu-Hua Chen, Ting-Yu Shih, Wei Hu, Jean-Dean Yang, Chun-Min Lee