Abstract: This document relates to methods and materials for treating a neuromyelitis optica (NMO) spectrum disorder such as NMO. For example, one or more tetracycline antibiotics can be administered to a mammal having, or at risk of developing, a NMO spectrum disorder to treat the mammal.

Abstract: An epigenome editing system generally includes three exogenous coding regions. The first exogenous coding region encodes a first polypeptide that includes an epigenetic editing domain and a domain that, in the presence of an inducer, forms a complex with a second polypeptide. The second exogenous coding region encodes the second polypeptide, which includes a dCas9 domain and a domain that, in the presence of the inducer, forms a complex with the first polypeptide. The third exogenous coding region encodes an sgRNA sequence that targets the dCas9 domain to a genomic locus.

Abstract: Systems and methods for throughput enhancement including asynchronous neighbor discovery among ultra-low power wireless network devices are provided. Specifically, techniques for discovering neighboring wireless devices within an energy-harvesting and/or energy constrained wireless communication network are provided such that the wireless devices are able to discover the greatest number of neighboring devices without exceeding the energy that they have accumulated by, for example, harvesting ambient sources or their allocated energy budget (e.g., battery/capacitor levels). Such devices are capable of transmitting and receiving data such as discovery messages and alternate between different operation states (e.g., listen, sleep, transmit) and are able to compute transitions rates in a centralized and/or distributed manner using either homogeneous or heterogeneous wireless devices.

Abstract: Systems and methods for throughput enhancement including asynchronous neighbor discovery among ultra-low power wireless network devices are provided. Specifically, techniques for discovering neighboring wireless devices within an energy-harvesting and/or energy constrained wireless communication network are provided such that the wireless devices are able to discover the greatest number of neighboring devices without exceeding the energy that they have accumulated by, for example, harvesting ambient sources or their allocated energy budget (e.g., battery/capacitor levels). Such devices are capable of transmitting and receiving data such as discovery messages and alternate between different operation states (e.g., listen, sleep, transmit) and are able to compute transitions rates in a centralized and/or distributed manner using either homogeneous or heterogeneous wireless devices.