Abstract: Methods and systems are provided for differentiating between cancer variants and somatic variants originating from hematopoietic cells in a cell free DNA sample. In some embodiments, the cancer variants can be distinguished from somatic variants originating from hematopoietic cells based on fragment size distribution.

Abstract: Presented herein are techniques for identifying and/or validating sequence variants in genomic sequence data. The techniques include generating an error rate reflective of sequence errors present in the genomic sequence data. The error rate may be used to validate potential sequence variants. The error rate may be based on errors identified during consensus sequence confirmation for sequence reads associated with individual unique molecular identifiers.

Abstract: Methods and systems are provided for determining a variant of interest by analyzing sizes and sequences of cfDNA fragments obtained from a test sample. The methods and systems provided herein implement processes that synergistically combine size and sequence information, thereby improving specificity and sensitivity of assays over conventional methods.

Abstract: A fusion protein of interleukin-2 and human serum albumin. By electroporating a plasmid carrying interleukin-2 and human serum albumin fusion gene into a CHO cell, a CHO monoclonal cell line stably and efficiently expressing a human recombinant protein is obtained. The monoclonal cell line can secrete and express a fusion protein of interleukin-2 and human serum albumin. The fusion protein can prolong the plasma half-life of human interleukin-2, and can be used for preparing human interleukin-2 drugs or drugs for treating various diseases such as tumors and immunodeficiency diseases.

Abstract: Methods and systems are provided for differentiating between cancer variants and somatic variants originating from hematopoietic cells in a cell free DNA sample. In some embodiments, the cancer variants can be distinguished from somatic variants originating from hematopoietic cells based on fragment size distribution.

Abstract: This disclosure provides a method, apparatus and electronic device for information processing. A specific implementation of the method includes: receiving a first setting operation performed by a first user on a first session message in a target session, wherein the first user is a member of the target session, and the first session message comprises one or more session messages in the target session; in response to the first setting operation, changing a first operation permission of at least part of members of the target session on the first session message to a second operation permission; wherein a permission scope of the second operation permission is less than a permission scope of the first operation permission.

Abstract: Presented herein are techniques for identifying and/or validating sequence variants in genomic sequence data. The techniques include generating an error rate reflective of sequence errors present in the genomic sequence data. The error rate may be used to validate potential sequence variants. The error rate may be based on errors identified during consensus sequence confirmation for sequence reads associated with individual unique molecular identifiers.

Abstract: A single winding hybrid excitation magnetic field modulation motor includes a stator, a rotor, a winding and a permanent magnet. The stator includes a stator iron core, a permanent magnet and a winding. The stator iron core includes stator teeth and stator yoke. Each stator tooth is split into an equal number of split teeth facing the air gap side. All permanent magnets are embedded in the grooves between the split teeth on the same stator tooth, the polarity of all permanent magnets located on the same stator tooth is the same, and the polarity of the permanent magnets on the adjacent stator teeth is opposite. A single non-overlapping concentrated winding is wound on all stator teeth, and DC current and AC current are simultaneously passed into each set of windings, in which field winding and permanent magnet are excited together to form hybrid excitation.

Abstract: The present application provides a splicing-screen display device which includes a display module, a processing module, a distribution module, and a driving module. The display module includes basic display modules and at least one supplementary display module arranged at joints between the basic display modules. The processing module is electrically connected to the display module. The distribution module is electrically connected to the processing module, and sends image signals to the basic display module and the supplementary display module. The driving module is arranged corresponding to the supplementary display module and electrically connected to the supplementary display module.

Abstract: Genomic insertions, duplications, and insertion/deletion (indels) account for ˜14% of human pathogenic mutations. Current gene editing methods cannot accurately or efficiently correct these abnormal genomic rearrangements, especially larger alterations (>100 bp). The presently disclosed compositions and methods accurately delete insertions/duplications and repair the deletion junction to improve the scope of gene therapies. For example, a Cas9 prime editor (PECas9) is combined with two prime editing guide RNAs (pegRNAs) targeting complementary DNA strands. PECas9 can replace an ˜1-kb genomic fragment with a desired sequence at the target site without requiring an exogenous DNA template.

Abstract: A splicing screen image display method, a related apparatus and a storage medium are provided. The method includes: obtaining a source image and resolution information of the splicing screen device, wherein the resolution information includes pixel widths of supplementary display modules, and the pixel widths are pixel sizes of the supplementary display modules in a width direction of a seam; adding frame display areas to outer edges of the source image, to form a target image corresponding to a resolution of the splicing screen device. The frame display areas are parallel to the seam, and a sum of pixel widths of the frame display areas that are parallel to each other is equal to a sum of the pixel widths of the supplementary display modules that are parallel to each other; and sending the target image to basic display modules and supplementary display modules, to display the target image.

Abstract: The present application provides a screen touch point positioning method, a device, and an electronic apparatus. The screen touch point positioning method includes: sequentially scanning each of the point positions on a screen to obtain each of the touch feature value of the point position, determining an end point coordinate; then aggregating adjacent sensed point positions of each row to touch line segments; further determining the line segment coordinates of the touch line segments; aggregating each of the touch line segments to obtain an aggregation touch region; finally determining a coordinate of a screen touch point. The embodiment of the present application solves an issue of a conventional screen touch point positioning method being complicated and time consuming.

Abstract: Provided is a dynamic projection system suitable for an automobile. The system includes a light source, a collimating lens, a first microlens array, an LCD projection source and a second microlens array, wherein the dynamic projection system further comprises a polarization grating used for separating P-polarized light and S-polarized light, and a wave plate array. The wave plate array includes a plurality of ½ wave plates arranged at intervals. The polarization grating is arranged in front of the first microlens array and the second microlens array, the ½ wave plates and the LCD projection source are arranged between the first microlens array and the second microlens array, and the ½ wave plates are arranged in front of the LCD projection source to play a role in converting one of the P-polarized light and the S-polarized light into the other one of the P-polarized light and the S-polarized light.

Abstract: The present application discloses a display device and electronic device. The display device is configured by sequentially configuring the corresponding first bias current, second bias current, and third bias in a start period, a sustain period, and an end period. The current value of the first bias current is greater than the current value of the second bias current, and/or the current value of the third bias current is greater than the current value of the second bias current, which improves the display quality and reduces display power consumption.

Abstract: A splicing screen image display method, a related apparatus and a storage medium are provided. The method includes: obtaining a source image and resolution information of the splicing screen device, wherein the resolution information includes pixel widths of supplementary display modules, and the pixel widths are pixel sizes of the supplementary display modules in a width direction of a seam; adding frame display areas to outer edges of the source image, to form a target image corresponding to a resolution of the splicing screen device. The frame display areas are parallel to the seam, and a sum of pixel widths of the frame display areas that are parallel to each other is equal to a sum of the pixel widths of the supplementary display modules that are parallel to each other; and sending the target image to basic display modules and supplementary display modules, to display the target image.

Abstract: The present application provides a splicing-screen display device which includes a display module, a processing module, a distribution module, and a driving module. The display module includes basic display modules and at least one supplementary display module arranged at joints between the basic display modules. The processing module is electrically connected to the display module. The distribution module is electrically connected to the processing module, and sends image signals to the basic display module and the supplementary display module. The driving module is arranged corresponding to the supplementary display module and electrically connected to the supplementary display module.

Abstract: Provided is a dynamic projection system suitable for an automobile. The system includes a light source, a collimating lens, a first microlens array, an LCD projection source and a second microlens array, wherein the dynamic projection system further comprises a polarization grating used for separating P-polarized light and S-polarized light, and a wave plate array. The wave plate array includes a plurality of ½ wave plates arranged at intervals. The polarization grating is arranged in front of the first microlens array and the second microlens array, the ½ wave plates and the LCD projection source are arranged between the first microlens array and the second microlens array, and the ½ wave plates are arranged in front of the LCD projection source to play a role in converting one of the P-polarized light and the S-polarized light into the other one of the P-polarized light and the S-polarized light.

Abstract: Provided herein are methods of determining a molecular response score. The molecular response score may be used to monitor and guide administration of treatment to a subject.

Abstract: Disclosed herein include systems, devices, and methods for grouping sequence reads and collapsing families of sequence reads that originate from the same DNA molecules using UMIs.

Abstract: A field modulated doubly salient motor and a design method for a distribution of salient pole teeth thereof are provided. The motor includes a stator and a mover, wherein the stator includes a stator core, two sets of windings, and two sets of permanent magnets. Each of the stator teeth is split into two field winding teeth, and each of the field winding teeth is split into two salient pole teeth. The two sets of windings are respectively armature windings and field windings, wherein the armature windings are wound around stator teeth, and the field windings are wound around adjacent field winding teeth that are split from different stator teeth. The two sets of tangentially magnetized permanent magnets are respectively placed on openings and bottoms of field winding slots, and permanent magnets placed in the same slot or at the same positions of adjacent slots have opposite polarities.