Abstract: A compound is provided as having the structure of Formula I, where: A and B are each independently a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group; L1, L2 are each independently a single bond, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group; Ar1, Ar2, Ar3, and Ar4 are each independently a hydrogen atom, a deuterium atom, a cyano group, a nitro group, an amino group, a hydroxy group, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group.

Abstract: Various examples are provided related to the application of a kernel neural network (KNN) to the analysis of high dimensional and ultrahigh dimensional data for, e.g., risk prediction. In one embodiment, a method includes training a KNN with a training set to produce a trained KNN model, determining a likelihood of a condition based at least in part upon an output indication of the trained KNN corresponding to one or more phenotypes, identifying treatment or prevention strategy for an individual based at least in part upon the likelihood of the condition. The KNN model includes a plurality of kernels as a plurality of layers to capture complexity between the data with disease phenotypes. The training set of data includes genetic information applied as inputs to the KNN and the phenotype(s), and the output indication is based upon analysis of data comprising genetic information from the individual by the trained KNN.

Abstract: Provided are use of a rare earth amino acid complex, a polylactic acid composition and a preparation method thereof. The rare earth amino acid complex is formed by complexing a rare earth metal ion with an amino acid; a rare earth element corresponding to the rare earth metal ion is one or more selected from the group consisting of lanthanum, cerium and samarium; and the amino acid is at least one selected from the group consisting of proline, L-phenylalanine, tyrosine and tryptophan.

Abstract: Provided in the present invention are a compound of general formula I or a pharmaceutically acceptable salt, a stereoisomer, an ester, a prodrug and a solvate thereof, a preparation method and use thereof, and in particular, the use of the compound of general formula I or the pharmaceutically acceptable salt, the stereoisomer, the ester, the prodrug and the solvate thereof as an HPK1 kinase inhibitor in the prevention and/or treatment of tumors and diseases caused by or associated with pathogen infection. The above-mentioned compound of general formula I contains at least one deuterium atom, and has high stability and good bioavailablility in an animal body.

Abstract: Use of an HPK1 kinase inhibitor in preventing and/or treating pathogen infection in animals. The HPK1 kinase inhibitor is a small molecule HPK1 kinase inhibitor, especially the compound of general formula I or a pharmaceutically acceptable salt, a stereoisomer, an ester, a prodrug, a solvate, or a deuterated compound thereof. The HPK1 kinase inhibitor can effectively treat diseases (such as feline infectious peritonitis) caused by infection of pathogens (specifically viruses, such as coronaviruses) in animals, improve animal survival, and provide enhanced commercial value and application prospects in the field of animal antiviral (specifically viruses, such as coronaviruses) medicaments.

Abstract: The present disclosure provides a heterocyclic compound and an organic electroluminescence device. The heterocyclic compound has a structure as shown in formula I.

Abstract: In the benzoxazole derivatives provided by the present disclosure, by defining the structure of the benzoxazole group and introducing at least two aromatic groups between the benzoxazole group and the triazine group, the two electron withdrawing groups in the benzoxazole and triazine can be effectively separated, avoiding the energy level drop caused by the proximity of the two electron withdrawing groups, and the triplet energy level of the molecule can be effectively adjusted, and the whole molecule has appropriate HOMO and LUMO values, to effectively improve the electron transport ability, and provide the benzoxazole derivatives with high electron mobility, excellent thermal stability and film stability, which is beneficial to improving luminous efficiency,

Abstract: Provided are a heterocyclic arylamine compound, an organic electroluminescent device and a display panel. The heterocyclic arylamine compound has a structure represented by Formula I. The structure of the heterocyclic arylamine compound is designed so that the heterocyclic arylamine compound has relatively high molecular polarizability, relatively high refractive index and relatively high crystallinity and may be used as a material of a capping layer to prepare a top-emitting OLED device, and the prepared OLED device has relatively high current efficiency and long lifetime.

Abstract: Disclosed is use of a compound in preventing and/or treating pathogen infection in animals. The compound is 4-(3-(((2-amino-5-(2-(1-methylpiperidin-4-yl)thiazol-5-yppyridin-3-ypoxy)methyl) phenyl)-2-methylbut-3-yn-2-ol, having a structure of formula I below. The compound can effectively treat diseases (such as feline infectious peritonitis) caused by pathogen (especially virus, such as coronavirus) infection in animals, improves the survival conditions of the animals, and has better commercial value and application prospect in the field of veterinary anti-pathogen (especially virus, such as coronavirus) therapies.

Abstract: Hydrogen ion water for use in cosmetic masks and skin care, as well as a method of making the same. The molecular expressions of hydrogen ions in the hydrogen ion water are H+(H2O)2, H+(H2O)3, H+(H2O)4, H+(H2O)5, and/or H+(H2O)6, where O is the oxygen atom in a water molecule, H is the hydrogen atom in water molecule, and H+ is a positively charged hydrogen ion. A water mask containing hydrogen ions includes the following components in the indicated weight ratios: 0.01-1% sodium chloride; 0.01-20% glycerol; 0.01-20% 1, 3-butanediol; with the rest being hydrogen ionized water.

Abstract: Drinking water, which specifically refers to proton-attached small-molecule drinking water, a preparation method therefor and an application occasion thereof. Small-molecule cluster water thereof is formed by distributing two to six water molecules around one H+. The small-molecule cluster water is atomized by running ordinary water through an atomizing device (30); the water is passed through an atomized water channel (60), sent to a hydrogen ion generating region (50), and is then mixed in a hydrogen ion and water vapor mixing region (150) of a mixing device (40). The advantages are: the small-molecule drinking water has a stable structure, and may be stored for a long time; the preparation method may be large-scale and has a wide range of practical application value; and drinking the small-molecule drinking water has a good effect on improving human health.

Abstract: The present invention provides a compound of general formula I, and a pharmaceutically acceptable salt, a stereoisomer, an ester, a prodrug, a solvate and a deuterated compound thereof, wherein the compound is an IRAK4 kinase inhibitor, and can be used for preventing and/or treating diseases related to IRAK4, such as autoimmune diseases, inflammatory diseases, cancers, heteroimmune diseases, thromboembolism, atherosclerosis, myocardial infarction and metabolic syndrome.

Abstract: The present invention provides a compound represented by a general formula I and a pharmaceutically acceptable salt, stereisomer, ester, prodrug, metabolite, solvate, or deuterated compound thereof. The compound is a JAK inhibitor and can prevent and/or treat an inflammatory disease or cancer in humans and/or animals.

Abstract: A method includes receiving, at a first network element of a network, a message to initiate a session of a communication service at a user device. The user device is associated with a plurality of billing accounts. The message includes a particular identifier of multiple identifiers associated with the user device. Each billing account of the plurality of billing accounts is associated with a respective identifier of the multiple identifiers. The method includes initiating the session via the first network element. The method also includes sending, from the first network element to a usage data processing system, a charge data record. The charge data record includes the particular identifier. The usage data processing system aggregates charge data records for the session from multiple network elements used during the session to enable the session to be billed to a particular billing account of the billing accounts corresponding to the particular identifier.

Abstract: An electric spraying device includes a spray emitter made of electrically conductive material, an electrode container made of electrically conductive material, and a voltage source. The electrode container has an opening at an upper end thereof, and the voltage source has a first pole electrically coupled to the spray emitter and a second pole electrically coupled to the electrode container. The spray emitter has an exit end disposed at or within the opening of the electrode container. The exit end of the spray emitter has a surface with a set of projections extending therefrom, and the set of projections are configured to form a concentrated electric field in response to an applied voltage from the voltage source between the first pole and the second pole. The spray emitter is constructed and arranged to conduct liquid along the surface to the set of projections, so as to polarize the liquid under the concentrated electric field and to dispense the liquid into the electrode container.

Abstract: A method includes receiving, at a first network element of a network, a message to initiate a session of a communication service at a user device. The user device is associated with a plurality of billing accounts. The message includes a particular identifier of multiple identifiers associated with the user device. Each billing account of the plurality of billing accounts is associated with a respective identifier of the multiple identifiers. The method includes initiating the session via the first network element. The method also includes sending, from the first network element to a usage data processing system, a charge data record. The charge data record includes the particular identifier. The usage data processing system aggregates charge data records for the session from multiple network elements used during the session to enable the session to be billed to a particular billing account of the billing accounts corresponding to the particular identifier.

Abstract: In some embodiments, in a method, for each array of at least a first array, a layout of the first array which comprises a plurality of cells, and a plurality of first circuit paths running across at least one side length in an array size configuration of the first array is received. Each of the plurality of cells is configured with a first node that is coupled to a respective one of the plurality of first circuit paths. A first representative characteristic associated with the plurality of first circuit paths is extracted. A universal cell model applied to each cell in a second array is generated based on a base cell model comprising parameters independent of positions in the second array, and the first representative characteristic.

Abstract: An apparatus includes means for accessing a communication service via a wireless network and for sending a first message and a second message via the wireless network. The apparatus also includes means for displaying a user interface and means for receiving a first selection and a second selection responsive to the user interface. The first and second selections respectively indicate work and personal billing accounts. The first message is associated with first usage profile-related information indicating work usage of the communication service that is to be billed to the work billing account. The second message is associated with second usage profile-related information indicating personal usage of the communication service that is to be billed to the personal billing account.

Abstract: A laser desorption electrospray ionization source includes a sample platform configured to support a sample material to be analyzed, an ion transfer tube having a first end and a second end, the first end facing in a direction of the sample platform, the second end connected to a mass spectrometer for providing sample molecules for spectral analysis, and a hollow emission needle having a tip that forms an electrospray nozzle, the tip extending to or into the first end of the ion transfer tube, such that the sample molecules pass the tip of the hollow emission needle on their way to the mass spectrometer.

Abstract: A method includes receiving input at a user interface displayed by a wireless device, the wireless device configured to access a communication service. The method also includes determining, at a processor of the wireless device, usage profile-related information based at least in part on the input. The method further includes generating a message associated with the usage profile-related information, the message indicating that usage of the communication service is to be billed to a first billing account of a plurality of billing accounts associated with the wireless device. The method also includes sending the message from the wireless device via a wireless network and directed to a network element.