Abstract: A liquid yeast one- and two-hybrid high-throughput library screening method and use thereof changes the screening of solid medium to liquid culture solution screening, avoiding a large number of plate coating work, and avoiding the tedious work of identifying single colonies one by one, which not only saves experiment time, but also reduces the cost and workload; at the same time, the present invention also combines high-throughput sequencing technology to improve the analysis throughput of yeast hybridization screening work, and can also improve the automation level of analysis, and can greatly reduce false negatives. More importantly, the present invention can solve the phenomenon of protein self-activation. By changing to liquid screening, known protein interaction information can be successfully obtained, which provides a new opportunity for protein-protein interaction research.

Abstract: The present disclosure relates a method for reducing animal weight, comprising administering to a patient in need thereof a therapeutically or prophylactically effective amount of a mulberry extract. The mulberry extract comprises: 3% to 99% of an alkaloid, 0.2% to 70% of a polysaccharide, 0% to 50% of an amino acid, 0% to 10% of flavone, and 0% to 25% of other components. The mulberry extract of the present disclosure can be used for controlling weight gain, and has a good therapeutic effect on type 2 diabetes with obesity.

Abstract: The present disclosure relates to an electronic device, a wireless communication method, and a computer-readable storage medium. The electronic device in the present disclosure comprises: a processing circuit, which is configured to: generate first downlink control information (DCI), wherein the first DCI comprises scheduling information of a plurality of data channels; and carries multiple pieces of first DCI by using the data channels. By means of using the electronic device, the wireless communication method and the computer-readable storage medium of the present disclosure, when DCI schedules a plurality of data channels, the probability of a UE correctly decoding the DCI can be improved, that is, the reliability of DCI transmission can be improved.

Abstract: The present disclosure provides a three-dimensional memory device and a manufacturing method thereof, the three-dimensional memory device including: a plurality of stacked layers; a storage channel structure vertically penetrating the stacked layers and comprising a first channel layer; a select gate structure on the plurality of stacked layers; and a select channel structure vertically penetrating the select gate structure and comprising a second channel layer; wherein an outer sidewall of the second channel layer is in contact with an inner sidewall of the first channel layer.

Abstract: The present disclosure provides a three-dimensional memory device and a manufacturing method thereof. The three-dimensional memory device comprises: a plurality of stacked layers; a storage channel structure vertically penetrating the stacked layers and comprising a first channel layer; a select gate structure on the plurality of stacked layers and comprising a conductive layer sandwiched between two dielectric layers; and a select channel structure vertically penetrating the select gate structure and comprising a second channel layer.

Abstract: The present disclosure provides a three-dimensional memory comprising: a storage channel structure vertically penetrating a plurality of stacked layers and comprising a first channel layer; a select gate structure on the plurality of stacked layers; and a select channel structure vertically penetrating the select gate structure and comprising: a block layer in contact with the select gate structure, an insulating layer covering the block layer, and a second channel layer in contact with the insulating layer and the first channel layer.

Abstract: The present application relates to novel compounds that have modulating or activating effect on the activity of adenosine A3 receptor, preparation methods for the series of compounds, pharmaceutical compositions of the series of compounds, and pharmaceutical uses of the series of compounds.

Abstract: The present invention belongs to the field of medicinal chemistry and relates to a class of substituted tricyclic compounds as PRMT5 inhibitors and the use thereof. Specifically, the present invention provides a compound represented by formula (A) or an isomer, pharmaceutically acceptable salt, solvate, crystal or prodrug thereof, a preparation method therefor, a pharmaceutical composition containing the compounds, and the use of the compounds or the composition for treating a disease mediated by PRMT5. The compounds of the present invention show significant inhibitory activity on PRMT5.

Abstract: A multifunctional fiber with full-spectrum infrared radiation, flame retardant and antibacterial functions, including a composite masterbatch having a water content of 30-50 ppm and accounting for 10-12% by weight, polyethylene terephthalate having a water content of 25-30 ppm or polycaprolactam high polymer having a water content of 50-70 ppm and accounting for 88-90% by weight; the fiber and its fabric possess multiple functions such as spectral heating, flame retardancy, anti-bacteria and anti-virus; after being illuminated for 5-10 minutes, the temperature difference of the fiber fabric of the present invention is higher than 15-20° C., the far-infrared emissivity is greater than 98%, the radiation temperature rise is greater than 3.0° C., the CLO value is greater than 0.5, the heat transfer coefficient is greater than 18.0w/(m2k), and the thermal resistance is less than 0.05 (m2k)/w.

Abstract: According to an aspect of the disclosure, a semiconductor device is provided. The semiconductor device includes a stack structure that includes alternating insulating layers and word line layers. The semiconductor device also includes a first channel structure extending through the stack structure, a first top select gate (TSG) layer over the stack structure, and a second TSG layer over the first TSG layer. The semiconductor device further includes a second channel structure extending through the first and second TSG layers, where the second channel structure is positioned over and coupled to the first channel structure.

Abstract: The present invention relates to methods and compositions for assessing copy number of a target polynucleotide in a sample, methods and compositions for establishing a standard curve for a target polynucleotide, and the uses of the methods and compositions for detecting a pathogen, e.g., human papillomavirus (HPV).

Abstract: The present invention relates to methods and compositions for assessing copy number of a target polynucleotide in a sample, methods and compositions for establishing a standard curve for a target polynucleotide, and the uses of the methods and compositions for detecting a pathogen, e.g., human papillomavirus (HPV).