Patents by Inventor Tinka Tuinstra

Tinka Tuinstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
    Patent number: 8067603
    Abstract: The invention relates to a group of novel benzimidazolone and quinazolinone derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these imidazolone and quinazolinone derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1): wherein the symbols have the meanings as given in the description.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: November 29, 2011
    Assignee: Solvay Pharmaceuticals B.V.
    Inventors: Jacobus A. J. Den Hartog, Gustaaf J. M. Van Scharrenburg, Herman H. Van Stuivenberg, Tinka Tuinstra, Jan-Willem Terpstra
  • Hydronopol substituted benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
    Patent number: 7851630
    Abstract: The invention relates to a group of hydronopol substituted benzimidazolone and quinazolinone derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel benzimidazolone and quinazolinone derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description.
    Type: Grant
    Filed: September 29, 2004
    Date of Patent: December 14, 2010
    Assignee: Solvay Pharmaceuticals B.V.
    Inventors: Jacobus A. J. Den Hartog, Samuel David, Daniel Jasserand, Gustaaf J. M. Van Scharrenburg, Herman H. Van Stuivenberg, Tinka Tuinstra
  • Neurotensin active 2,3,diaryl-pyrazolidine derivatives
    Patent number: 7186741
    Abstract: The invention relates to a group of novel 2,3 diaryl-pyparazolidine derivatives having formula (1). The symbols used in formula (1) have the meanings given in the specification. The compounds have inhibiting activity on enzymes which degrade the neuropeptide neurotensin and can be used for the treatment of affections and diseases caused by disturbances of the neurotensin mediated transmission.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: March 6, 2007
    Assignee: Solvay Pharmaceuticals B.V.
    Inventors: Roelof W. Feenstra, Josephus H. M. Lange, Maria L. Pras-Raves, Cornelis G. Kruse, Herman H. van Stuivenberg, Tinka Tuinstra, Hiskias Keizer
  • Hydronopol substituted benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
    Publication number: 20050075355
    Abstract: The invention relates to a group of hydronopol substituted benzimidazolone and quinazolinone derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel benzimidazolone and quinazolinone derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved.
    Type: Application
    Filed: September 29, 2004
    Publication date: April 7, 2005
    Inventors: Jacobus Den Hartog, Samuel David, Daniel Jasserand, Gustaaf Van Scharrenburg, Herman Van Stuivenberg, Tinka Tuinstra
  • Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
    Publication number: 20050070528
    Abstract: The invention relates to a group of novel benzimidazolone and quinazolinone derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these imidazolone and quinazolinone derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1): wherein the symbols have the meanings as given in the description.
    Type: Application
    Filed: September 22, 2004
    Publication date: March 31, 2005
    Inventors: Jacobus Den Hartog, Gustaaf Van Scharrenburg, Herman Van Stuivenberg, Tinka Tuinstra, Jan-Willem Terpstra
  • Neurotensin active 2,3,diaryl-pyrazolidine derivatives
    Publication number: 20040242493
    Abstract: The invention relates to a group of novel 2,3 diaryl-pyparazolidine derivatives having formula (1). The symbols used in formula (1) have the meanings given in the specification. The compounds have inhibiting activity on enzymes which degrade the neuropeptide neurotensin and can be used for the treatment of affections and diseases caused by disturbances of the neurotensin mediated transmission.
    Type: Application
    Filed: March 23, 2004
    Publication date: December 2, 2004
    Inventors: Roelof W. Feenstra, Josephus H.M. Lange, Maria L. Pras-Raves, Cornelis G. Kruse, Herman H. van Stuivenberg, Tinka Tuinstra, Hiskias Keizer