Abstract: For improving control of the release of an agent (7) from a dental appliance (1), it is provided to accurately control the formation and geometry of a multitude of micro-reservoirs (3), which are formed in a core (4) of the appliance (1) during the fabrication of the same, preferably within a limited region of interest (13). This approach allows accurate control of the rate at which the micro-reservoirs (3) release the agent (7) into the mouth and the total dosage that will be delivered to the patient by the appliance (1). It is provided to carry out this approach using a computer-implemented method that enables rapid fabrication of a series (30) of such appliances (1) which are each personalized to the specific needs of a patient.

Abstract: For improving the quality of electrostimulation therapy, a computer-implemented method is proposed that allows patient-specific choice and/or configuration of an electrical stimulation device 1 that is designed and usable for tACS electrostimulation therapy of neuronal tissue, for example in the brain. The method benefits from pre-existing images, for example acquired using a medical imaging technique such as MRT or PET. Based on data extracted from such an image, a computer simulates possible electrical field distributions E (x,y,z), which would be achievable if the device is configured with a certain set of configuration parameters. By varying these parameters and repeating the simulations, the method allows optimization of the configuration parameters for a given device design. As a result, the method delivers a set of optimized configuration parameters, which, if applied to the device, allow a “best-case” electrostimulation with the device that is tailor-made for the patient's needs.

Abstract: A novel ultra-thin neural implant (1) is provided that is based on a cellulose thin film (4) featuring an array (2) of electrodes (3). Due to the use of cellulose as the base material, the implant (1) can be safely handled during a micro-surgery, despite its high softness and conformability. Such an implant (1) may be useful in numerous applications ranging from electrical stimulation in neural prostheses, electro-stimulated regeneration of neural tissue to accurate recording of nerve signals. The robustness of the implant (1) results from a woven fabric (5) that is integrated in the cellulose carrier thin film (4). Several approaches for enhancing the tissue compatibility of the implant (1) are also provided.

Abstract: For improving the sensitivity, lifetime and energy consumption of a dielectric elastomer transducer (1) to be used as a sensor, it is suggested that a dielectric layer (3) enclosed by two electrodes (2) of the transducer (1) includes a nanoscale volume of a fluid (15) such that the dielectric layer (3) is rendered compressible and/or displaceable out of a volume enclosed by the two electrodes (2). The advantage of such a design is that, although the dielectric layer (3) and possible buffer layers (4) separating the electrodes (2) from the dielectric layer (3) may all have thicknesses in the order of a few ?m or even in the sub-?m range, the transducer (1) is rendered highly compliant due to the movability of the fluid (15). In consequence, a large nominal capacitance of the transducer (1) as well as a large relative capacitance change (up to twenty times that of the nominal capacitance) can be achieved in conjunction with a very high sensitivity.

Abstract: For improving the functionality and bio-compatibility of dental appliances (2), a novel process is described for making a thermoplastic functional foil (1), from which such dental appliances (2) may be obtained by thermoforming the functional foil (1). A carrier liquid (9) containing an organic and preferably bio-based polymer (6) is enriched with an agent (7) and applied onto a solid thermoplastic core foil (13). After evaporating of a solvent contained in the carrier liquid (9), a uniform and highly homogenous functional coating (5) is obtained on the core foil (13). After thermoforming of the foil (1), the dental appliance (2) thus features an outer protective coating (5) offering enhanced functionality. Moreover, it is possible to reload the agent (7) into the coating (5) of the appliance (2) using a reload-liquid (23).

Abstract: For improving the quality of use of intraoral orthodontic devices (1) such as dental splints (2) to be worn on teeth as well as for increasing their functionality, such devices (1) are fabricated at least in part, but preferably fully from bio-based materials (5). In particular when using a design featuring a cap layer (4) covering an inner stiff core (3) and including a bio-based material (5), which can be additionally chosen such that it can take-up a significant amount of liquid by swelling, both the micro-deformability of the device (1) can be improved—resulting in increased wearing comfort for the patient and less microplastic contamination for the patient through fossil-based plastic abrasions—and novel functions can be realized, for example releasing substances (9) such as drugs or flavor molecules or bio-based antimicrobial or protective agents from the device (1).

Abstract: For exploiting novel use-cases, in particular sophisticated human-machine interaction, with an intraoral electronic tongue monitoring system designed to be worn by a user on the upper or lower jaw and featuring a support sheet bearing a number of intraoral sensors arranged in an array for recording tongue movement and/or tongue pressure, it is proposed that the system comprises at least one extraoral sensor located outside of the oral cavity delimited by the teeth when the system is in place, in particular such that extraoral and/or intraoral and/or interlabial movements of the tongue and/or lip pressure can be recorded with the system and/or such that the system may be used as an input device controlled through tongue movement using a human-machine-interface provided by the system.

Abstract: For improving the electroactivity and long-term stability of a neural interface, a novel neural probe (1) is proposed that is formed from a fiber (6), preferably by thermal imprinting, and wherein a polymer thin film (5) is employed for carrying a conducting thin film to be used as a recording or stimulation electrode (4). Due to this specific choice of materials and design, the electrode (4) is rendered compliant with respect to the fiber (6) on a nanometer to micrometer scale and offers a surface that is tailor-made for adhering to nervous tissue.

Abstract: For improving the sensitivity, lifetime and energy consumption of a dielectric elastomer transducer (1) to be used as a sensor, it is suggested that a dielectric layer (3) enclosed by two electrodes (2) of the transducer (1) includes a nanoscale volume of a fluid (15) such that the dielectric layer (3) is rendered compressible and/or displaceable out of a volume enclosed by the two electrodes (2). The advantage of such a design is that, although the dielectric layer (3) and possible buffer layers (4) separating the electrodes (2) from the dielectric layer (3) may all have thicknesses in the order of a few ?m or even in the sub-?m range, the transducer (1) is rendered highly compliant due to the movability of the fluid (15). In consequence, a large nominal capacitance of the transducer (1) as well as a large relative capacitance change (up to twenty times that of the nominal capacitance) can be achieved in conjunction with a very high sensitivity.

Abstract: An optically pumped semiconductor disk laser including a pump light source, at least one semiconductor body (2), which semiconductor body (2) has at least one window region (8), an active region (7) and a reflection device (P), which reflection device has at least one first P-reflection element (P1) for the pump wavelength. The first P-reflection element (P1) is embodied and arranged such that pump light emerging from the pump light source (3) can be guided for at least two passes through the active region (7). A total thickness of the active region (7) and of the window region (8) in the direction of an optical axis of the semiconductor disk laser is less than three times the laser wavelength in the active region (7).

Abstract: An optically pumped semiconductor disk laser including a pump light source, at least one semiconductor body (2), which semiconductor body (2) has at least one window region (8), an active region (7) and a reflection device (P), which reflection device has at least one first P-reflection element (P1) for the pump wavelength. The first P-reflection element (P1) is embodied and arranged such that pump light emerging from the pump light source (3) can be guided for at least two passes through the active region (7). A total thickness of the active region (7) and of the window region (8) in the direction of an optical axis of the semiconductor disk laser is less than three times the laser wavelength in the active region (7).