Patents by Inventor Tinoush Moulaei

Tinoush Moulaei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GRIFFITHSIN MUTANTS
    Publication number: 20220315629
    Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
    Type: Application
    Filed: April 19, 2022
    Publication date: October 6, 2022
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, University of Louisville Research Foundation, Inc., University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
  • ANTI-VIRAL COMPOSITIONS AND METHODS OF MAKING AND USING
    Publication number: 20220289798
    Abstract: Provided herein are GRFT variants and methods of using such GRFT variants. The GRFT variants described herein can be PEGylated, which significantly improves the pharmacokinetics and decreases the immunogenicity of the GFRT composition.
    Type: Application
    Filed: September 10, 2020
    Publication date: September 15, 2022
    Applicants: University of Louisville Research Foundation, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Joshua Fuqua, Krystal Hamorsky, Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer
  • Griffithsin mutants
    Patent number: 11339195
    Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: May 24, 2022
    Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
  • GRIFFITHSIN MUTANTS
    Publication number: 20200087359
    Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
    Type: Application
    Filed: November 27, 2019
    Publication date: March 19, 2020
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, University of Louisville Research Foundation, Inc., University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
  • Griffithsin mutants
    Patent number: 10501507
    Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: December 10, 2019
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Louisville Research Foundation, Inc., University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
  • Monomeric griffithsin tandemers
    Patent number: 9982025
    Abstract: The invention provides a construct containing two or more monomeric griffithsin molecules, optionally joined by a linker, as well as conjugate comprising the construct, a nucleic acid encoding the construct or conjugate, vectors, and cells. A nucleic acid encoding the polypeptide or fusion protein, as well as compositions or cells comprising the polypeptide, fusion protein, or nucleic acid also are provided.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: May 29, 2018
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Barry R. O'Keefe, Alexander Wlodawer, Tinoush Moulaei
  • GRIFFITHSIN MUTANTS
    Publication number: 20180016307
    Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
    Type: Application
    Filed: February 10, 2016
    Publication date: January 18, 2018
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Serv, University of Louisville Research Foundation, Inc., University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
  • MONOMERIC GRIFFITHSIN TANDEMERS
    Publication number: 20160108097
    Abstract: The invention provides a construct containing two or more monomeric griffithsin molecules, optionally joined by a linker, as well as conjugate comprising the construct, a nucleic acid encoding the construct or conjugate, vectors, and cells. A nucleic acid encoding the polypeptide or fusion protein, as well as compositions or cells comprising the polypeptide, fusion protein, or nucleic acid also are provided.
    Type: Application
    Filed: June 5, 2014
    Publication date: April 21, 2016
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Barry R. O'Keefe, Alexander Wlodawer, Tinoush Moulaei