Patents by Inventor Tiong Han Toh
Tiong Han Toh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11920191Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.Type: GrantFiled: January 18, 2021Date of Patent: March 5, 2024Assignee: Life Technologies CorporationInventors: Mingsong Chen, Kuan Moon Boo, Tiong Han Toh, Mauro Aguanno, Soo Yong Lau, Huei Yeo, Wei Fuh Teo
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Publication number: 20230273448Abstract: An illumination system includes a surface configured to have an imaging target placed thereon, a light source, a beam splitter and at least a first mirror. The beam splitter is configured to split the beam of light from the light source and the first mirror is configured to reflect a first beam from the beam splitter onto the surface with the imaging target. An imaging system includes an imaging surface configured to have an imaging target placed thereon, a mirror, and a capturing device. The capturing device is configured to capture an image of the imaging target through a path of emitted light that extends from the imaging target, reflects off of the mirror, and to the capturing device. The mirror, the capturing device, or both are configured to move in a diagonal direction with respect to the imaging surface to reduce a length of the path of emitted light. Systems and methods to calibrate an imaging system to remove or reduce non-uniformities within images of samples due to imaging system properties.Type: ApplicationFiled: January 24, 2023Publication date: August 31, 2023Inventors: Mingsong CHEN, Benyong SHI, Tiong Han TOH, Huei Steven YEO
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Publication number: 20230080468Abstract: A surgical fastener assembly includes one or more arrays of fasteners, each of the fasteners including a head portion opposite to a sharp portion. Each of the head portions of the fasteners is held by a fastener head holding member. A receiver member is aligned with each of the one or more arrays of fasteners. A fluid actuator is provided for each of the one or more arrays of fasteners, and it is contractible and expandable. Each of the fluid actuators is configured to provide a force against its corresponding array of fasteners to propel the sharp portions of the fasteners towards the receiver member and also configured to provide a force to free the head portions from the fastener head holding member.Type: ApplicationFiled: February 17, 2021Publication date: March 16, 2023Applicant: Step Surgical Solutions PTE Ltd.Inventors: Yosef Hazan, Nir Goldenberg, Dotan Tromer, Avshalom Shenhav, Arnon Hadas, Yaakov Greenberg, Tiong Han Toh
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Patent number: 11592679Abstract: An illumination system includes a surface configured to have an imaging target placed thereon, a light source, a beam splitter and at least a first mirror. The beam splitter is configured to split the beam of light from the light source and the first mirror is configured to reflect a first beam from the beam splitter onto the surface with the imaging target. An imaging system includes an imaging surface configured to have an imaging target placed thereon, a mirror, and a capturing device. The capturing device is configured to capture an image of the imaging target through a path of emitted light that extends from the imaging target, reflects off of the mirror, and to the capturing device. The mirror, the capturing device, or both are configured to move in a diagonal direction with respect to the imaging surface to reduce a length of the path of emitted light. Systems and methods to calibrate an imaging system to remove or reduce non-uniformities within images of samples due to imaging system properties.Type: GrantFiled: October 13, 2017Date of Patent: February 28, 2023Assignee: LIFE TECHNOLOGIES HOLDINGS PTE LIMITEDInventors: Mingsong Chen, Benyong Shi, Tiong Han Toh, Huei Steven Yeo
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Publication number: 20210214771Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.Type: ApplicationFiled: January 18, 2021Publication date: July 15, 2021Inventors: Mingsong CHEN, Kuan Moon BOO, Tiong Han TOH, Mauro AGUANNO, Soo Yong LAU, Huei YEO, Wei Fuh TEO
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Patent number: 10931872Abstract: A method to maximize use of the field of view for an imaging system is provided herein. An imaging device can be part of the imaging system and include a detection unit and an alignment unit. The method includes capturing an initial image of an object and then calculating a rotational angle and zoom factor for the object in order to maximize the object's footprint within the field of view. Once the calculations are complete a computer can instruct the detection and alignment units to reconfigure their orientations relative to the object.Type: GrantFiled: August 21, 2019Date of Patent: February 23, 2021Assignees: LIFE TECHNOLOGIES HOLDINGS PTE LIMITED, PIERCE BIOTECHNOLOGY, INC.Inventors: Yanpeng Cao, Suk Hong, Tiong Han Toh, Steven Yeo, Benyong Shi, Kok Siong Teo, Brian Webb
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Patent number: 10627638Abstract: An illumination system includes a surface configured to have an imaging target placed thereon, a light source, a beam splitter and at least a first mirror. The beam splitter is configured to split the beam of light from the light source and the first mirror is configured to reflect a first beam from the beam splitter onto the surface with the imaging target. An imaging system includes an imaging surface configured to have an imaging target placed thereon, a mirror, and a capturing device. The capturing device is configured to capture an image of the imaging target through a path of emitted light that extends from the imaging target, reflects off the mirror, and to the capturing device. The mirror, the capturing device, or both are configured to move in a diagonal direction with respect to the imaging surface to reduce a length of the path of emitted light. Systems and methods to calibrate an imaging system to remove or reduce non-uniformities within images of samples due to imaging system properties.Type: GrantFiled: September 5, 2018Date of Patent: April 21, 2020Assignee: LIFE TECHNOLOGIES HOLDING PTE LIMITEDInventors: Mingsong Chen, Benyong Shi, Tiong Han Toh, Steven Yeo, Soo Fan Phua
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Publication number: 20200112677Abstract: A method to maximize use of the field of view for an imaging system is provided herein. An imaging device can be part of the imaging system and include a detection unit and an alignment unit. The method includes capturing an initial image of an object and then calculating a rotational angle and zoom factor for the object in order to maximize the object's footprint within the field of view. Once the calculations are complete a computer can instruct the detection and alignment units to reconfigure their orientations relative to the object.Type: ApplicationFiled: August 21, 2019Publication date: April 9, 2020Inventors: Yanpeng Cao, Suk Hong, Tiong Han Toh, Steven Yeo, Benyong Shi, Kok Siong Teo, Brian Webb
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Publication number: 20200101461Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.Type: ApplicationFiled: September 26, 2019Publication date: April 2, 2020Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Chee Kiong LIM, Way Xuang LEE, Wuh Ken LOH, Chee Wee CHING, Chin Yong KOO, Siew Ying KOH, Tiong Han TOH, Kuan Moon BOO, Soo Yong LAU
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Patent number: 10471431Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.Type: GrantFiled: February 4, 2015Date of Patent: November 12, 2019Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Chee Kiong Lim, Way Xuang Lee, Wuh Ken Loh, Chee Wee Ching, Chin Yong Koo, Siew Ying Koh, Tiong Han Toh, Kuan Moon Boo, Soo Yong Lau
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Patent number: 10432857Abstract: A method to maximize use of the field of view for an imaging system is provided herein. An imaging device can be part of the imaging system and include a detection unit and an alignment unit. The method includes capturing an initial image of an object and then calculating a rotational angle and zoom factor for the object in order to maximize the object's footprint within the field of view. Once the calculations are complete a computer can instruct the detection and alignment units to reconfigure their orientations relative to the object.Type: GrantFiled: October 13, 2017Date of Patent: October 1, 2019Assignees: LIFE TECHNOLOGIES HOLDINGS PTE LIMITED, PIERCE BIOTECHNOLOGY, INC.Inventors: Yanpeng Cao, Suk Hong, Tiong Han Toh, Steven Yeo, Benyong Shi, Kok Siong Teo, Brian Webb
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Publication number: 20190126281Abstract: A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.Type: ApplicationFiled: August 29, 2018Publication date: May 2, 2019Inventors: Yong CHU, Jeffrey MARKS, Jacob FREUDENTHAL, Mingsong CHEN, Tiong Han TOH, Mauro AGUANNO, Lik Seng LAU, Lian Seng LOH, Kok Siong TEO, Zeng Wei CHU, Xin MATHERS, Michael UY, Huei Steven YEO, Kuan Moon BOO, Way Xuang LEE, Chin Yong KOO, Wei Fuh TEO, Soo Yong LAU, Hon Siu SHIN, Zeqi TAN, Thomas WESSEL, David WOO
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Patent number: 10239059Abstract: In one aspect, a thermal cycler system is disclosed. The thermal cycler can be comprised of a device housing and a cover that is operably connected to the device housing. The cover can include a handle portion, a device lid portion, a sample block platen, and a link bar. The device lid portion is attached to the proximal side of the handle portion with a first pin. The sample block platen is operably connected to the handle portion such that the sample block platen is positioned against the sample block when the handle portion is flush with the device lid portion and the cover is in a closed position. The link bar is pivotably connected to the device housing at a first terminal end portion and a second pin at an opposite second terminal end portion, wherein the handle portion is elevated away from the device lid portion before the cover is moved to an open position.Type: GrantFiled: February 14, 2014Date of Patent: March 26, 2019Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Tiong Han Toh, Wuh Ken Loh, Kuan Moon Boo, Sandro Klein, Daniel Welsh
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Publication number: 20180373049Abstract: An illumination system includes a surface configured to have an imaging target placed thereon, a light source, a beam splitter and at least a first mirror. The beam splitter is configured to split the beam of light from the light source and the first mirror is configured to reflect a first beam from the beam splitter onto the surface with the imaging target. An imaging system includes an imaging surface configured to have an imaging target placed thereon, a mirror, and a capturing device. The capturing device is configured to capture an image of the imaging target through a path of emitted light that extends from the imaging target, reflects off the mirror, and to the capturing device. The mirror, the capturing device, or both are configured to move in a diagonal direction with respect to the imaging surface to reduce a length of the path of emitted light. Systems and methods to calibrate an imaging system to remove or reduce non-uniformities within images of samples due to imaging system properties.Type: ApplicationFiled: September 5, 2018Publication date: December 27, 2018Inventors: Mingsong CHEN, Benyong SHI, Tiong Han TOH, Steven YEO, Soo Fan PHUA
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Publication number: 20180124313Abstract: A method to maximize use of the field of view for an imaging system is provided herein. An imaging device can be part of the imaging system and include a detection unit and an alignment unit. The method includes capturing an initial image of an object and then calculating a rotational angle and zoom factor for the object in order to maximize the object's footprint within the field of view. Once the calculations are complete a computer can instruct the detection and alignment units to reconfigure their orientations relative to the object.Type: ApplicationFiled: October 13, 2017Publication date: May 3, 2018Inventors: Yanpeng CAO, Suk HONG, Tiong Han TOH, Steven YEO, Benyong SHI, Kok Siong TEO, Brian WEBB
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Publication number: 20180120575Abstract: An illumination system includes a surface configured to have an imaging target placed thereon, a light source, a beam splitter and at least a first mirror. The beam splitter is configured to split the beam of light from the light source and the first mirror is configured to reflect a first beam from the beam splitter onto the surface with the imaging target. An imaging system includes an imaging surface configured to have an imaging target placed thereon, a mirror, and a capturing device. The capturing device is configured to capture an image of the imaging target through a path of emitted light that extends from the imaging target, reflects off of the mirror, and to the capturing device. The mirror, the capturing device, or both are configured to move in a diagonal direction with respect to the imaging surface to reduce a length of the path of emitted light. Systems and methods to calibrate an imaging system to remove or reduce non-uniformities within images of samples due to imaging system properties.Type: ApplicationFiled: October 13, 2017Publication date: May 3, 2018Inventors: Mingsong CHEN, Benyong SHI, Tiong Han TOH, Steven YEO
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Publication number: 20160228876Abstract: A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.Type: ApplicationFiled: February 5, 2016Publication date: August 11, 2016Inventors: Yong Chu, Jeffrey Marks, Jacob Freudenthal, Mingsong Chen, Tiong Han Toh, Mauro Aguanno, Lik Seng Lau, Lian Seng Loh, Kok Siong Teo, Zeng Wei Chu, Xin Mathers, Michael Uy, Huei Yeo, Kuan Moon Boo, Way Xuang Lee, Chin Yong Koo, Wei Fuh Teo, Soo Yong Lau, Hon Siu Shin, Zeqi Tan, Thomas Wessel, Woo David
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Publication number: 20160230210Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.Type: ApplicationFiled: February 5, 2016Publication date: August 11, 2016Inventors: Mingsong CHEN, Kuan Moon BOO, Tiong Han TOH, Mauro AGUANNO, Soo Yong LAU, Huei Steven YEO, Wei Fuh TEO
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Publication number: 20160228875Abstract: In one aspect, a thermal cycler system is disclosed. The thermal cycler can be comprised of a device housing and a cover that is operably connected to the device housing. The cover can include a handle portion, a device lid portion, a sample block platen and a link bar. The device lid portion is attached to the proximal side of the handle portion with a pin. The sample block platen is operably connected to the handle portion such that the sample block platen is positioned against the sample block when the handle portion is flush with the device lid portion and the cover is in a closed position. The link bar is operably connected to the device housing and the pin such that a distal side of the handle portion is elevated away from the device lid portion when the cover is moved to an open position.Type: ApplicationFiled: February 14, 2014Publication date: August 11, 2016Inventors: Tiong Han Toh, Wuh Ken LOH, Kuan Moon BOO, Sandro David KLEIN, Daniel WELSH
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Patent number: D865218Type: GrantFiled: November 10, 2017Date of Patent: October 29, 2019Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Xin Mathers, Sandro Klein, Tiong Han Toh, Huei Steven Yeo