Patents by Inventor Tirayut Vilaivan

Tirayut Vilaivan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4-diamino-6-ethylpyrimidine derivatives with antimalarial activities against
    Patent number: 11028072
    Abstract: The present invention relates to 2,4-diamino-6-ethylpyrimidine derivatives that are inhibitors of wild type and quadruple mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum. They also show in vitro antimalarial activities against Plasmodium falciparum for both wild type and mutant that are comparable to or better than pyrimethamine. In addition, the compounds of the present invention show a good selectivity to Plasmodium falciparum and exhibit lower cytotoxicity than pyrimethamine.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: June 8, 2021
    Assignee: National Science and Technology Development Agency
    Inventors: Sumalee Kamchonwongpaisan, Netnapa Charoensetakul, Krisana Peewasan, Jarunee Vanichtanankul, Roonglawan Rattanajak, Supannee Taweechai, Tosapol Anukunwithaya, Aphisit Yoomuang, Yongyuth Yuthavong, Tirayut Vilaivan
  • 2,4-DIAMINO-6-ETHYLPYRIMIDINE DERIVATIVES WITH ANTIMALARIAL ACTIVITIES AGAINST PLASMODIUM FALCIPARUM
    Publication number: 20200239445
    Abstract: The present invention relates to 2,4-diamino-6-ethylpyrimidine derivatives that are inhibitors of wild type and quadruple mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum. They also show in vitro antimalarial activities against Plasmodium falciparum for both wild type and mutant that are comparable to or better than pyrimethamine. In addition, the compounds of the present invention show a good selectivity to Plasmodium falciparum and exhibit lower cytotoxicity than pyrimethamine.
    Type: Application
    Filed: September 16, 2016
    Publication date: July 30, 2020
    Applicant: National Science and Technology Development Agency
    Inventors: Sumalee KAMCHONWONGPAISAN, Netnapa CHAROENSETAKUL, Krisana PEEWASAN, Jarunee VANICHTANANKUL, Roonglawan RATTANAJAK, Supannee TAWEECHAI, Tosapol ANUKUNWITHAYA, Aphisit YOOMUANG, Yongyuth YUTHAVONG, Tirayut VILAIVAN
  • Antimalarial compounds with flexible side-chains
    Patent number: 8530491
    Abstract: The present invention relates to novel compounds that are inhibitors of wild type and mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum, which are useful for the treatment of malaria. It also relates to processes of making and using such compounds. The antimalarial compounds of the present invention have low toxicity to a host infected with the malarial parasite, and are potent when administered in pharmaceutical compositions.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: September 10, 2013
    Assignee: Medicines for Malaria Venture (MMV)
    Inventors: Yongyuth Yuthavong, Tirayut Vilaivan, Sumalee Kamchonwongpaisan, Bongkoch Tarnchompoo, Chawanee Thongpanchang, Penchit Chitnumsub, Jirundon Yuvaniyama, David Matthews, William Charman, Susan Charman, Livia Vivas, Sanjay Babu Katiyar
  • ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS
    Publication number: 20090099220
    Abstract: The present invention relates to novel compounds that are inhibitors of wild type and mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum, which are useful for the treatment of malaria. It also relates to processes of making and using such compounds. The antimalarial compounds of the present invention have low toxicity to a host infected with the malarial parasite, and are potent when administered in pharmaceutical compositions.
    Type: Application
    Filed: October 8, 2008
    Publication date: April 16, 2009
    Inventors: Yongyuth YUTHAVONG, Tirayut Vilaivan, Sumalee Kamchonwongpaisan, Bongkoch Tarnchompoo, Chawanee Thongpanchang, Penchit Chitnumsub, Jirundon Yuvaniyama, David Matthews, William Charman, Susan Charman, Livia Vivas, Sanjay Babu Katiyar
  • Homologous peptide nucleic acids
    Patent number: 7098321
    Abstract: The invention discloses compounds of the formula: where n is 1, or 2 to 200 in which case each recurring unit can be the same or different, B is a protected or unprotected base capable of Watson-Crick or of Hoogsteen pairing.
    Type: Grant
    Filed: February 4, 2003
    Date of Patent: August 29, 2006
    Assignee: Isis Innovation Limited
    Inventors: Gordon Lowe, Tirayut Vilaivan