Patents by Inventor Tirtha Chakraborty

Tirtha Chakraborty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MANUFACTURING METHODS FOR PRODUCTION OF RNA TRANSCRIPTS
    Publication number: 20160024547
    Abstract: Described are methods for production of RNA transcripts using a non-amplified, linearized DNA template in an in vitro transcription reaction. Enzymatic 5? capping and oligo dT purification can also be included in the methods.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Inventors: Stephane BANCEL, William Joseph ISSA, John Grant AUNINS, Tirtha CHAKRABORTY
  • HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA
    Publication number: 20160022840
    Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
    Type: Application
    Filed: March 7, 2014
    Publication date: January 28, 2016
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles
  • LONG-LIVED POLYNUCLEOTIDE MOLECULES
    Publication number: 20160024181
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of long-lived polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Inventors: Stephen G. Hoge, Eric Yi-Chun Huang, Tirtha Chakraborty, Sayda M. Elbashir
  • Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders
    Patent number: 9233141
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: January 12, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles
  • IN VIVO PRODUCTION OF PROTEINS
    Publication number: 20150376648
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: August 12, 2015
    Publication date: December 31, 2015
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • Modified polynucleotides encoding aquaporin-5
    Patent number: 9220792
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and modified mRNA (mmRNA) molecules.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: December 29, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles
  • Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders
    Patent number: 9220755
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: December 29, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles
  • In vivo production of proteins
    Patent number: 9221891
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 29, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS
    Publication number: 20150368665
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: June 25, 2015
    Publication date: December 24, 2015
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • Modified polynucleotides encoding granulysin
    Patent number: 9216205
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: December 22, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles
  • Modified polynucleotides for the production of secreted proteins
    Patent number: 9192651
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: March 9, 2013
    Date of Patent: November 24, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles
  • MODIFIED POLYNUCLEOTIDES FOR ALTERING CELL PHENOTYPE
    Publication number: 20150315541
    Abstract: The present invention relates to compositions, methods and kits using cell phenotype altering polynucleotides, cell phenotype altering primary transcripts and cell phenotype altering mmRNA molecules.
    Type: Application
    Filed: December 12, 2013
    Publication date: November 5, 2015
    Inventors: Stephane Bancel, Antonin de Fougerolles, Susan Whoriskey, Tirtha Chakraborty, Eric Yi-Chun Huang
  • Modified polynucleotides encoding septin-4
    Patent number: 9149506
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: October 6, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS
    Publication number: 20150246139
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: April 23, 2015
    Publication date: September 3, 2015
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • Modified polynucleotides encoding citeD4
    Patent number: 9114113
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: August 25, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles
  • Modified polynucleotides encoding basic helix-loop-helix family member E41
    Patent number: 9107886
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: August 18, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles
  • Modified polynucleotides encoding copper metabolism (MURR1) domain containing 1
    Patent number: 9095552
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: August 4, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles
  • Modified polynucleotides for treating galactosylceramidase protein deficiency
    Patent number: 9089604
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: July 28, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles, Ron Weiss
  • Modified polynucleotides for treating protein deficiency
    Patent number: 9061059
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: June 23, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles, Ron Weiss
  • Modified polynucleotides encoding aryl hydrocarbon receptor nuclear translocator
    Patent number: 9050297
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: June 9, 2015
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles, Ron Weiss