Abstract: Heart strain determination includes receiving a series of 2D-slice images as input. A pose estimation module estimates a slicing-pose of the inputted series of 2D-slice images in the heart. A 3D deformation estimation module estimates a 3D deformation field from the series of 2D-slice images and the estimated slicing-pose. A strain measurement module computes a heart strain measure from the 3D deformation field and a predefined definition for strain computation.

Abstract: In hemodynamic determination in medical imaging, the classifier is trained from synthetic data rather than relying on training data from other patients. A computer model (in silico) may be perturbed in many different ways to generate many different examples. The flow is calculated for each resulting example. A bench model (in vitro) may similarly be altered in many different ways. The flow is measured for each resulting example. The machine-learnt classifier uses features from medical scan data for a particular patient to estimate the blood flow based on mapping of features to flow learned from the synthetic data. Perturbations or alterations may account for therapy so that the machine-trained classifier may estimate the results of therapeutically altering a patient-specific input feature. Uncertainty may be handled by training the classifier to predict a distribution of possibilities given uncertain input distribution.

Abstract: Systems and methods for determining a semantic image understanding of medical imaging studies are provided. A plurality of medical imaging studies associated with a plurality of medical imaging modalities is provided. Metadata associated with each of the plurality of medical imaging studies is generated by performing a plurality of semantic image analysis tasks using one or more machine learning based networks. The metadata associated with each of the plurality of medical imaging studies is output.

Abstract: A system includes propagation logic configured to obtain one or more contours for one or more directed viewframes within viewframe data. The one or more contours each having a set of tracking points. The viewframe data further includes intermediate viewframes among the one or more directed viewframes. The propagation logic is configured propagate the one or more contours across the intermediate viewframes via iterative viewframe-to-viewframe propagation. The iterative viewframe-to-viewframe propagation include optical flow analysis to determine candidate locations for tracking points followed by one or more validations using motion priors and/or resolved feature tracking.

Abstract: In hemodynamic determination in medical imaging, the classifier is trained from synthetic data rather than relying on training data from other patients. A computer model (in silico) may be perturbed in many different ways to generate many different examples. The flow is calculated for each resulting example. A bench model (in vitro) may similarly be altered in many different ways. The flow is measured for each resulting example. The machine-learnt classifier uses features from medical scan data for a particular patient to estimate the blood flow based on mapping of features to flow learned from the synthetic data. Perturbations or alterations may account for therapy so that the machine-trained classifier may estimate the results of therapeutically altering a patient-specific input feature. Uncertainty may be handled by training the classifier to predict a distribution of possibilities given uncertain input distribution.

Abstract: A medical knowledge base in a digital, clinical system is upgraded. A storage with a knowledge base, being a SNOMED knowledge base, is provided in a web ontology format. Procedural data, representing clinical procedures for evaluation of a patient's health state, is received. The received procedural data is mapped in a set of SNOMED expressions. The SNOMED expressions are converted into statements in the web ontology format. The SNOMED knowledge base is upgraded with the received procedural data by adding the statements in the SNOMED knowledge base for providing a processable file with an upgraded version of the SNOMED knowledge base.

Abstract: Systems and methods for estimating local conductivities from anatomical information derived from MR images, ECG, and sparse contact maps are provided. ECG features and sparse measurements are mapped to an anatomical model represented as a graph. Graph convolutional layers and a multilayer perceptron are applied to extract local and global features respectively. The local and global features are combined and further processed by a series of fully connected layers to regress a set of vertex conductivities.

Abstract: For predicting stroke risk, an artificial intelligence rapidly generates flow information from input of geometric parameters of a carotid of a patient. An image processor predicts the stroke risk from the flow information. In one approach, the values of the geometric parameters of the carotid of the patient are perturbed based on uncertainty. The artificial intelligence generates candidate flow information for each perturbation. The candidate flow information sufficiently matching a measurement of flow for the patient is used as the flow information for stroke risk prediction.

Abstract: Techniques for processing multiple cardiac images are disclosed. The processing may take place either during or after an angiography exam of a coronary artery of interest. The multiple cardiac images are obtained either during or after the angiography exam. Each of the multiple cardiac images depicts a respective segment of the coronary artery of interest. A geometric structure of the coronary artery of interest is determined based on the multiple cardiac images. A lumped parameter model of the coronary artery of interest is determined based on the geometric structure, and respective values of at least one hemodynamic index at a position of the coronary artery of interest is determined based on the lumped parameter model of the coronary artery of interest.

Abstract: A method includes processing at least one input dataset (using a multi-level processing algorithm, one or more of the at least one input dataset comprising imaging data of an echocardiography of a cardiovascular system of a patient. The multi-level processing algorithm comprises a multi-task level and a consolidation-task level. An input of the consolidation-task level is coupled to an output of the multi-task level. The multi-task level is configured to determine multiple diagnostic metrics of the cardiovascular system based on the at least one input dataset. The consolidation-task level is configured to determine a fitness of the cardiovascular system of the patient.

Abstract: One or more example embodiments of the present invention relates to a method for the automated determination of examination results in an image sequence from multiple chronologically consecutive frames, the method comprising determining diagnostic candidates in the form of contiguous image regions in the individual frames for a predefined diagnostic finding; and for a number of the diagnostic candidates, determining which candidate image regions in other frames correspond to the particular diagnostic candidate, determining whether the candidate image regions of the particular diagnostic candidate in the other frames overlap with other diagnostic candidates, generating a graph containing the determined diagnostic candidates of the frames as nodes and the determined overlaps as edges, and generating communities from nodes connected via edges.

Abstract: Various aspects of the disclosure generally pertain to determining estimates of hemodynamic properties based on angiographic x-ray examinations of a coronary system. Various aspects of the disclosure specifically pertain to determining such estimates based on single frame metrics operating on two-dimensional images. For example, the fractional flow reserve (FFR) can be computed.

Abstract: Techniques for processing one or more frames of an angiogram are disclosed. The processing may take place during or after an angiography exam. The one or more frames of the angiogram are acquired during the angiography exam. The one or more frames are processed to determine, based on at least one pre-defined criterion, whether the angiogram at least comprises one frame with a diagnostic value among the one or more frames. If the angiogram comprises at least one frame with the diagnostic value, based on the angiogram, a score quantifying the diagnostic value of the angiogram is determined using a trained machine-learning (ML) algorithm. Techniques for processing, e.g., ranking/sorting, multiple angiograms associated with an anatomical region of interest of a patient are also provided, by which a respective score for each of the multiple angiograms is determined using the techniques for processing one or more frames of an angiogram.

Abstract: A soft tissue emulation system, comprising: an input interface, configured to obtain imaging data of the soft tissue; a computing unit, configured to implement an artificial neural network, which is adapted to generate, using the obtained imaging data as input, and a biophysical model of the soft tissue, a digital twin of the soft tissue at different times, wherein the biophysical model describes the response of the soft tissue to at least one of thermal stimuli or electromechanical stimuli over time, and wherein the generation of the digital twin at one time is independent of the generation of the digital twin at another time; and an output interface, configured to output a representation of the soft tissue over time based on the digital twin generated by the artificial neural network.

Abstract: Systems and methods are provided for training an artificial intelligence model for detecting calcified portions of a vessel in an input medical image. One or more first medical images of a vessel in a first modality and one or more second medical image of the vessel in a second modality are received. Calcified portions of the vessel are detected in the one or more first medical images, The artificial intelligence model is trained for detecting calcified portions of the vessel in the input medical image in the second modality based on the one or more second medical images and the detected calcified portions of the vessel detected in the one or more first medical images.

Abstract: For shape determination of cardiac anatomy with a medical imager, irregularities in motion, poor image quality, and misalignment of imaging planes are counteracted by a process relying on alignment of contours in combination with selection and fitting of a motion model. Contours are extracted from 2D images and aligned for each frame, which is extracted from the sequence of 2D images. The alignment may use a translation for each frame and rotation across frames for improved performance. A motion model is fit to the aligned contours and tested. If insufficient (greater than threshold difference), other motion models are aligned and tested. Motion models may be created on demand for improved performance. If sufficient, the shape of the heart structure is determined from the fit model.

Abstract: Angiography angles are determined. Patient information and target vessel information are obtained, wherein the patient information defines individual medical information of a patient and wherein the target vessel information defines at least one target vessel to be imaged. At least one angiography angle is determined based on the patient information and the target vessel information. Angiograms obtained using the at least one angiography angle are analyzed to determine a vessel coverage of the target vessel and based on the vessel coverage determines additional angiography angles.

Abstract: Systems and methods for predicting a location of a target heart region for cardiac ablation can include one or more processors generating a 3D model of a heart of a patient based on medical images of the patient, and estimating, using the 3D model of the heart and electrophysiology data of the patient, one or more mechanical properties that drive motion of the patient's heart. The one or more processors can generate, using the 3D model and the one or more mechanical properties, a simulated motion pattern of the patient's heart over at least a portion of a cardiac cycle, and identify a region of interest (ROI) of the heart of the patient to be radiated. The one or more processors can determine, using the simulated motion pattern of the heart of the patient, a location of the ROI at a predefined time instance within the cardiac cycle.

Abstract: Systems and methods for simulating radiation effect for cardiac ablation can include a processor generating a heart simulation model configured to simulate electrical activities of the heart of the patient. The processor can determine a simulated post-radiation state of the heart of the patient by adjusting the heart simulation model to account for an effect of a radiation treatment plan on simulated electrical activities of the heart of the patient. The processor can simulate, using the adjusted heart simulation model, the simulated post-radiation state of the heart with a stimulation to induce a heart rhythm disorder, determine whether the heart rhythm disorder is induced based on electrical activities generated when simulating the simulated post-radiation state of the heart with the stimulation, and output an indication of whether the heart rhythm disorder is induced. The processor can suggest modifications to the radiation plan if the heart rhythm disorder is induced.

Abstract: Machine-based risk prediction or assistance is provided for peri-procedural complication, such as peri-procedural myocardial infarction (PMI). A machine-learned model is used to predict risk of PMI and/or recommend courses of action to avoid PMI in PCI. Various combinations of types or modes of information are used in the prediction, such as both imaging and non-imaging data. The prediction may be made prior to, during, and/or after PCI using the machine-learned model to more quickly reduce the chance of PMI. The workflows for prior, during, and/or post PCI incorporate the risk prediction and/or risk-based recommendations to reduce PMI for patients.