Patents by Inventor Tiziano Scubla

Tiziano Scubla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for purifying 4-(nitrooxy)butyl(2S)-2-(6-methoxy-2-naphthyl) propanoate
    Patent number: 8329937
    Abstract: The present invention relates to a method for purifying naproxcinod comprising the steps of: a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or two phases dispersion under stirring to a temperature ranging from ?20° C. to 10° C. c) optionally seeding the solution with crystals of naproxcinod d) stirring, by maintaining the temperature in the range from ?40° C. to 10° C. e) collecting the formed solid by maintaining the temperature under 15° C. A further object of the invention is a crystalline form of naproxcinod.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: December 11, 2012
    Assignee: Nicox S.A.
    Inventors: Pietro Allegrini, Tiziano Scubla, Nicoletta Toniutti, Romano Rivolta, Thierry Delahaique
  • Process for the preparation of keto compounds
    Patent number: 8236961
    Abstract: A process for the preparation of 4-[1-oxo-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-?,?-dimethylbenzeneacetic acid, useful as an intermediate for the preparation of fexofenadine, is provided.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: August 7, 2012
    Assignee: Dipharma Francis s.r.l.
    Inventors: Tiziano Scubla, Pietro Allegrini, Eliana Rocchini, Caterina Napoletano
  • Process for the preparation of cholanic acids
    Patent number: 7982062
    Abstract: A process for the preparation of high purity cholanic acids, typically in purity equal to or higher than 99%.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: July 19, 2011
    Assignee: Dipharma Francis s.r.l.
    Inventors: Pietro Allegrini, Tiziano Scubla, Fausto Gorassini, Andrea Finco
  • Process for the purification of 1,4-butanediol mononitrate
    Patent number: 7947855
    Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: May 24, 2011
    Assignee: Dipharma S.p.A.
    Inventors: Tiziano Scubla, Nevio Francescutti, Fausto Gorassini, Graziano Castaldi
  • Process for the mononitration of alkanediols
    Patent number: 7851649
    Abstract: A process for the preparation of compounds of formula HO-A-ONO2??(I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with “stabilized” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: December 14, 2010
    Assignee: Dipharma S.p.A.
    Inventors: Nevio Francescutti, Tiziano Scubla, Fausto Gorassini, Graziano Castaldi
  • METHOD FOR PURIFYING 4-(NITROOXY)BUTYL(2S)-2-(6-METHOXY-2-NAPHTHYL) PROPANOATE
    Publication number: 20100256411
    Abstract: The present invention relates to a method for purifying naproxcinod comprising the steps of: a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or two phases dispersion under stirring to a temperature ranging from ?20° C. to 10° C. c) optionally seeding the solution with crystals of naproxcinod d) stirring, by maintaining the temperature in the range from ?40° C. to 10° C. e) collecting the formed solid by maintaining the temperature under 15° C. A further object of the invention is a crystalline form of naproxcinod.
    Type: Application
    Filed: June 18, 2009
    Publication date: October 7, 2010
    Applicant: NICOX S.A.
    Inventors: Pietro Allegrini, Tiziano Scubla, Nicoletta Toniutti, Romano Rivolta, Thierry Delahaique
  • PROCESS FOR THE PREPARATION OF KETO COMPOUNDS
    Publication number: 20080293948
    Abstract: A process for the preparation of 4-[1-oxo-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-?,?-dimethylbenzeneacetic acid, useful as an intermediate for the preparation of fexofenadine, is provided.
    Type: Application
    Filed: May 15, 2008
    Publication date: November 27, 2008
    Applicant: DIPHARMA FRANCIS s.r.l.
    Inventors: Tiziano Scubla, Pietro Allegrini, Eliana Rocchini, Caterina Napoletano
  • PROCESS FOR THE PURIFICATION OF 1,4-BUTANEDIOL MONONITRATE
    Publication number: 20080293961
    Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.
    Type: Application
    Filed: July 2, 2008
    Publication date: November 27, 2008
    Applicant: DIPHARMA S.P.A.
    Inventors: Tiziano Scubla, Nevio Francescutti, Fausto Gorassini, Graziano Castaldi
  • PROCESS FOR THE MONONITRATION OF ALKANEDIOLS
    Publication number: 20080146830
    Abstract: A process for the preparation of compounds of formula HO-A-ONO2 ??(I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with “stabilised” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.
    Type: Application
    Filed: February 25, 2008
    Publication date: June 19, 2008
    Applicant: DIPHARMA S.P.A.
    Inventors: Nevio FRANCESCUTTI, Tiziano SCUBLA, Fausto GORASSINI, Graziano CASTALDI
  • PROCESS FOR THE PREPARATION OF CHOLANIC ACIDS
    Publication number: 20080064888
    Abstract: A process for the preparation of high purity cholanic acids, typically in purity equal to or higher than 99%.
    Type: Application
    Filed: September 11, 2007
    Publication date: March 13, 2008
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Pietro ALLEGRINI, Tiziano SCUBLA, Fausto GORASSINI, Andrea FINCO
  • Process for the mononitration of alkanediols
    Patent number: 7335789
    Abstract: A process for the preparation of compounds of formula (I): HO-A-ONO2??(I) wherein A is a C2-C6 alkylene chain, the compounds of formula (I) being synthesized by nitration of the corresponding alkanediols with “stabilized” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: February 26, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Nevio Francescutti, Tiziano Scubla, Fausto Gorassini, Graziano Castaldi
  • Process for the purification of 1,4-butanediol mononitrate
    Publication number: 20060135806
    Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.
    Type: Application
    Filed: November 6, 2003
    Publication date: June 22, 2006
    Inventors: Tiziano Scubla, Nevio Francescutti, Fausto Gorassini, Graziano Castaldi
  • Process for the mononitration of alkanediols
    Publication number: 20060128983
    Abstract: A process for the preparation of compounds of formula HO-A-ONO2??(I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with “stabilised” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.
    Type: Application
    Filed: November 6, 2003
    Publication date: June 15, 2006
    Inventors: Nevio Francescutti, Tiziano Scubla, Fausto Gorassini, Graziano Castaldi