Abstract: A finger-mounted device may include finger-mounted units. The finger-mounted units may each have a body that serves as a support structure for components such as force sensors, accelerometers, and other sensors and for haptic output devices. The body may have sidewall portions coupled by a portion that rests adjacent to a user's fingernail. The body may be formed from deformable material such as metal or may be formed from adjustable structures such as sliding body portions that are coupled to each other using magnetic attraction, springs, or other structures. The body of each finger-mounted unit may have a U-shaped cross-sectional profile that leaves the finger pad of each finger exposed when the body is coupled to a fingertip of a user's finger. Control circuitry may gather finger press input, lateral finger movement input, and finger tap input using the sensors and may provide haptic output using the haptic output device.

Abstract: An implantable spacer for placement between adjacent spinous processes in a spinal motion segment is provided. The spacer includes a body defining a longitudinal axis and passageway. A first arm and a second arm are connected to the body. Each arm has a pair of extensions and a saddle defining a U-shaped configuration for seating a spinous process therein. Each arm has a proximal earning surface and is capable of rotation with respect to the body. An actuator assembly is disposed inside the passageway and connected to the body. When advanced, a threaded shaft of the actuator assembly contacts the earning surfaces of arms to rotate them from an undeployed configuration to a deployed configuration. In the deployed configuration, the distracted adjacent spinous processes are seated in the U-shaped portion of the arms.

Abstract: A method includes determining one or more metrics of a surgical task being performed by a surgeon based at least partially upon a type of the surgical task being performed and a video of the surgical task being performed. The method also includes determining a surgical skill of the surgeon during the surgical task based at least partially upon the video, the one or more metrics, or a combination thereof.

Abstract: Systems and methods for constructing and managing a unique road sign knowledge graph across various countries and regions is disclosed. The system utilizes machine learning methods to assist humans when comparing a new sign template with a plurality of stored sign templates to reduce or eliminate redundancy in the road sign knowledge graph. Such a machine learning method and system is also used in providing visual attributes of road signs such as sign shapes, colors, symbols, and the like. If the machine learning determines that the input road sign template is not found in the road sign knowledge graph, the input sign template can be added to the road sign knowledge graph. The road sign knowledge graph can be maintained to add signs templates that are not already in the knowledge graph but are found in real-world by integrating human annotator's feedback during ground truth generation for machine learning.

Abstract: A metal junction thermoelectric device includes at least one thermoelectric element. The thermoelectric element has first and second opposite sides, and a first conductor made from a first metal, and a second conductor made from a second metal. The first and second conductors are electrically interconnected in series, and the first and second conductors are arranged to conduct heat in parallel between the first and second sides. The first metal has a first occupancy state, and the second metal has a second occupancy state that is lower than the first occupancy state. A temperature difference between the first and second sides of the thermoelectric element causes a charge potential due to the difference in occupancy states of the first and second metals. The charge potential generates electrical power.

Abstract: Provided herein is a surgical instrument comprising a cap having a first and second aperture extending therethrough, a first extendable and retractable member having a distal end coupled to a first coupling, a first arm extending from the first coupling and pivotable with respect to the distal end of the first member, and a second arm connected to the first arm through a second coupling and pivotable, with respect to the first arm, a second extendable and retractable member having a distal end coupled to a third coupling, a third arm extending from the second coupling, the third arm pivotable, with respect to the distal end of the second member, and a fourth arm connected to the third arm through a fourth coupling and pivotable, with respect to the third arm, a first end effector connected to the second arm and a second end effector connected to the fourth arm.

Abstract: A extended reality communication system, methods, apparatus, and computer program product are disclosed. The communication system provides for remote real-time communication between a proctor and an operator, where the operator is performing tasks on a local work object, such as a patient. The system incorporates a combination of haptic, virtual keyboard, VR, XR, and audio inputs to provide communication of instructions between the proctor and the operator that are projected as a holographic image in a field of view on the patient. The system includes a proctor station and an operator station communicatively coupled with one or more servers.

Abstract: An electronic device comprising a cell region comprising stacks of alternating dielectric materials and conductive materials. A pillar region is adjacent to the cell region and comprises storage node segments adjacent to adjoining oxide materials and adjacent to a tunnel region. The storage node segments are separated by a vertical portion of the tunnel region. A high-k dielectric material is adjacent to the conductive materials of the cell region and to the adjoining oxide materials of the pillar region. Additional electronic devices are disclosed, as are methods of forming an electronic device and related systems.

Abstract: Methods and apparatus for treating disorders of the ear, nose, throat or paranasal sinuses, including methods and apparatus for dilating ostia, passageways and other anatomical structures, endoscopic methods and apparatus for endoscopic visualization of structures within the ear, nose, throat or paranasal sinuses, navigation devices for use in conjunction with image guidance or navigation system and hand held devices having pistol type grips and other handpieces.

Abstract: The present disclosure relates to antibodies or antigen-binding fragments thereof that bind specifically to the glucagon-like peptide 1 receptor (GLP1R) protein, and methods of use thereof. In various embodiments, the antibodies or antigen-binding fragments thereof are fully human antibodies that bind to GLP1R. In some embodiments, the antibodies or antigen-binding fragments thereof are useful for attenuating GLP1R activity, thus providing a means of treating, preventing, or alleviating a disease, disorder or condition associated with GLP1R in humans. In some embodiments, the antibodies or antigen-binding fragments thereof elevate glucose levels when administered to a subject and thereby treat hypoglycemia, such as post-bariatric hypoglycemia (PBH), by attenuating insulin secretion from pancreatic beta cells and decreasing insulin expression.

Abstract: Provided herein as a transoral minimally invasive method and a system thereof for the treatment of gastrointestinal diseases and/or obesity, which at least partially encircles a part of the gastrointestinal tract, such as esophagus of the patient by advancing an elongated deformable portion of a neurostimulator assembly endoluminally to the subfascial area from the outer wall of the esophagus and introducing the elongated deformable portion sub-fascially in the subfascial area, whereby at least one part of the encircled esophagus will be modulated using a modulator.

Abstract: Methods and systems of building a knowledge graph based on event-based ontology of a scene and vehicle trajectory in the scene. Image data corresponding to a plurality of scenes captured by one or more cameras is received. Event-based ontology data corresponding to events occurring in the plurality of scenes is received. Via an object-tracking machine-learning model, the system determines (i) a presence of a plurality of vehicles in the image data, and (ii) a plurality of vehicle trajectories, each vehicle trajectory associated with a respective one of the vehicles. Using a clustering model, the vehicle trajectories are clustered. A knowledge graph is augmented based on the clustered vehicle trajectories and the event-based ontology.

Abstract: Methods and system of building and augmenting a knowledge graph regarding ontology of events occurring in images. Image data corresponding to a plurality of scenes captured by one or more cameras is received. A knowledge graph is built with event-based ontology data corresponding to events occurring in the plurality of scenes. One or more of the scenes is displayed to a plurality of crowdsourcing workers which provide natural-language input including event-based semantic annotations corresponding to the scene. Using natural language processing on the input, triples are generated. The knowledge graph is augmented with the generated triples to yield an augmented knowledge graph for use in determining event-based ontology associated with the plurality of scenes.

Abstract: An input device, such as a mouse, can include a housing defining an exterior grip portion and an internal volume, a sensor assembly disposed in the internal volume, and an emitter electrically coupled to the sensor assembly. In response to the sensor assembly detecting a first touch input on the housing, the emitter sends a first signal including information regarding an angular position of the grip portion. In response to the sensor assembly detecting a second touch input on the housing, the emitter sends a second signal including information regarding a direction of a force exerted on the housing from the second touch input.

Abstract: A computer input system includes a mouse including a housing having an interior surface defining an internal volume and a sensor assembly disposed in the internal volume. A processor is electrically coupled to the sensor assembly and a memory component having electronic instructions stored thereon that, when executed by the processor, causes the processor to determine an orientation of the mouse relative to a hand based on a touch input from the hand detected by the sensor assembly. The mouse can also have a circular array of touch sensors or lights that detect hand position and provide orientation information to the user.

Abstract: A computer system can include an input device having a housing defining an internal volume. The housing can include a grip portion and a base portion defining an aperture. The computer system can also include a tilt sensor disposed in the internal volume, a position sensor disposed at the aperture, and a processor. The processor can be electrically coupled to the position sensor, the tilt sensor, and a memory component storing electronic instructions that, when executed by the processor, cause the processor to receive a first input from the tilt sensor, receive a second input from the position sensor, determine, based on the first and second inputs, if the base is in contact with a support surface and an angle of the base relative to the support surface. The processor can also output a signal based on the angle if the base is in contact with the support surface.

Abstract: The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated.

Abstract: A system for evaluating a cell sample may comprise a specimen slide scanner, a computer-based image analyzer, and an evaluation subsystem. The specimen slide scanner may be configured to acquire images of an entire surface of a microscope slide upon which the cell sample is mounted. The computer-based image analyzer may be configured to identify one or more follicular clusters within each of the images acquired by the specimen slide scanner. The evaluation subsystem may be configured to (i) compare a number of follicular clusters identified by the computer-based image analyzer to an adequacy threshold, and (ii) present an adequacy notification to a user when the number of the follicular clusters identified by the computer-based image analyzer exceeds the adequacy threshold.

Abstract: The present invention provides apelin receptor (APLNR) modulators that bind to APLNR and methods of using the same. The invention includes APLNR modulators such as antibodies, or antigen-binding fragments thereof, which inhibit or attenuate APLNR-mediated signaling. The invention includes APLNR modulators such as antibodies, or antibody fusion proteins thereof, that activate APLNR-mediated signaling. According to certain embodiments of the invention, the antibodies or antigen-binding fragments or antibody fusion proteins are fully human antibodies that bind to human APLNR with high affinity. The APLNR modulators of the invention are useful for the treatment of diseases and disorders associated with APLNR signaling and/or APLNR cellular expression, such as cardiovascular diseases, angiogenesis diseases, metabolic diseases and fibrotic diseases.