Abstract: The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of Type VII Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.

Abstract: A compound, composition, or method for treating cancer is disclosed. The compound (that can be used in the composition and/or method) can include or pharmaceutically acceptable salts or solvates thereof. R1a-R1d, R2-R3 (and R4 where applicable), and A---B can be as defined herein.

Abstract: Numerous embodiments for processing the current output of a vector-by-matrix multiplication (VMM) array in an artificial neural network are disclosed. The embodiments comprise a summer circuit and an activation function circuit. The summer circuit and/or the activation function circuit comprise circuit elements that can be adjusted in response to the total possible current received from the VMM to optimize power consumption.

Abstract: Methods of braiding using a braiding mechanism are described. The braiding mechanism includes an array of filament engagement elements, a mandrel extending from the center of the circular array, a plurality of actuators disposed operably about the array, and a rotating mechanism adapted to rotate one or more filaments. The plurality of filaments are loaded onto the mandrel by looping a middle portion of each filament of the plurality of filaments over an end of the mandrel and extend radially toward and contact the circumferential edge of the circular array of filament engagement elements. The plurality of actuators are operated to engage a first subset of the plurality of filaments and move the engaged filaments in a generally radial direction to a position beyond the circumferential edge of the array. The rotating mechanism is operated to move the engaged filaments about the mandrel axis.

Abstract: A method of treatment is disclosed, comprising administering a composition of Cyclodextrin and reduced, nanonized L-Glutathione to a patient in need of treatment, wherein the L-Glutathione molecule is non-acetylated, non-Esterified, and non-fatty acid attached.

Abstract: Methods, systems, and devices for accessing a multi-level memory cell are described. The memory device may perform a read operation that includes pre-read portion and a read portion to access the multi-level memory cell. During the pre-read portion, the memory device may apply a plurality of voltages to a plurality of memory cells to identify a likely distribution of memory cells storing a first logic state. During the read portion, the memory device may apply a first read voltage to a memory cell based on performing the pre-read portion. The memory device may apply a second read voltage to the memory cell during the read portion that is based on the first read voltage. The memory device may determine the logic state stored by the memory cell based on applying the first read voltage and the second read voltage.

Abstract: An interlayer structure having a cellulose ester layer for use in bilayer laminates is described herein. The cellulose ester layer provides rigidity and support to multilayer interlayers comprising an array of different layers. Due to the diverse properties of the cellulose ester layers, the present interlayers can be useful in producing structural laminates having high stiffness and which possess good optical clarity for a variety of applications, including outdoor structural applications and HMI devices.

Abstract: Numerous embodiments of analog neural memory arrays are disclosed. In certain embodiments, each memory cell in the array has an approximately constant source impedance when that cell is being operated. In certain embodiments, power consumption is substantially constant from bit line to bit line within the array when cells are being read. In certain embodiments, weight mapping is performed adaptively for optimal performance in power and noise.

Abstract: An ergonomic frame-filler placement tool is manually operable to supply a vacuum fluid flow at a distal end of the tool that can be used by a worker to pick up and hold a piece of frame-filler material to the distal end of the tool, which enables the worker to manipulate the tool to position the piece of frame-filler material over a desired location of a fuselage mandrel and then manually stop the vacuum fluid flow at the distal end of the tool to position the piece of frame-filler material at the desired location on the mandrel.

Abstract: Autoland systems and processes for landing an aircraft without pilot intervention are described. In implementations, the autoland system includes a memory operable to store one or more modules and at least one processor coupled to the memory. The processor is operable to execute the one or more modules to identify a plurality of potential destinations for an aircraft; calculate a merit for each potential destination identified; select a destination based upon the merit; and create a route from a current position of the aircraft to an approach fix associated with the destination that accounts for the terrain characteristic(s) and/or obstacle characteristic(s).

Abstract: Cleaning fixtures for cleaning a showerhead assembly are disclosure. The cleaning fixtures include: a fixture body incorporating three or more cavities, each cavity being separate from an adjacent cavity by a partition, and a number of channels associated with each cavity for fluidly connecting the cavities with an upper surface of the fixture body.

Abstract: A puncture needle can comprise an elongate portion, a puncture component associated with a distal end of the elongate portion, and a spacer associated with a distal portion of the elongate portion, where the spacer can be configured to contact a wall of the delivery catheter lumen to prevent contact between the puncture component and the wall. A puncture needle can comprise an elongate portion and a puncture component associated with a distal end of the elongate portion, where the puncture component comprises a blade edge on a distal edge, and where the puncture component is configured to be advanceable through a lumen of a delivery catheter without the blade edge sticking to a wall of the lumen.

Abstract: The current invention reports a method for purifying an antibody by reducing the content of a host cell protein. The method employs a wash step with a low conductivity aqueous solution in an affinity chromatography.

Abstract: Disclosed herein is a system and method for real time engagement between a plurality of users in a social set-up by means of an application software connected to a server. The application software enables a user to interact with other user numbers in real time. The method further enables a user to check-in to a business-member based on a real-time location of the user-member.

Abstract: Various embodiments of tandem row decoders are disclosed. Each embodiment of a tandem row decoder comprises a word line decoder and a control gate decoder. The tandem row decoder exhibits reduced leakage current on the word line and the control gate line when the tandem row decoder is not enabled.

Abstract: Various embodiments of a three-dimensional (3D) tactile map system and methods of implementing the system are described. In one example, the tactile map system includes a map base having a substantially planar substrate defining an x-y plane. The map base includes a top base surface and a bottom base surface, where the top base surface includes a ground surface texture. The tactile map system also includes a 3D scaled representation of a structure attached to the top surface of the map base. The 3D scaled representation can be configured with dimensions that are in proportion to the structure and extend in a z-direction from the base. The z-direction being orthogonal to the x-y plane. The 3D scaled representation includes a plurality of identified surfaces, each of the plurality of identified surfaces having a surface type of a plurality of surface types, each surface type corresponding to a selected surface texture.

Abstract: A groundworks method for a foundation designed to form a foundation slab for an onshore wind turbine includes: excavating in the soil a depression intended to receive, on the one hand, an anchoring means which will be used to connect the mast to the future foundation and, on the other hand, the pouring of concrete to form said foundation after setting. According to the invention, the method further comprises digging a trench at the center of the depression, placing a compressible material in this trench, covering said material with a layer of concrete and waiting for it to set. A foundation is built for a wind turbine, by pouring concrete, the central part of which does not bear on the soil or barely bears on the soil. As a result, the pressure on the soil is increased and is delimited over a peripheral annular zone situated around its central part.

Abstract: An apparatus and method are provided for capturing and sterilizing contaminants, such as viruses and the like. Air containing the contaminants is drawn into the apparatus that comprises a housing having a customized number and arrangement of dissimilar treatment chambers to remove a particular contaminate targeted for removal. The treatment chambers are selected from a group of pre manufactured, self-contained chambers that are singularly or in combination inserted into the housing and within an air flow path created by a fan. The group of treatment chambers include a UV chamber, a temperature chamber and an ozone converter chamber. The customized arrangement of treatment chambers are each placed in the air flow path and programmed to provide customized sterilization of any type of contaminate while persons are present in the space being treated.

Abstract: Provided herein is a formulation to pre-treat an organ prior to transplantation and for inducing mitochondrial morphological alterations.

Abstract: Embodiments of a method for device fabrication by reverse pitch reduction flow include forming a first pattern of features above a substrate and forming a second pattern of pitch-multiplied spacers subsequent to forming the first pattern of features. In embodiments of the invention the first pattern of features may be formed by photolithography and the second pattern of pitch-multiplied spacers may be formed by pitch multiplication. Other methods for device fabrication are provided.