Abstract: The present invention provides a method for predicting a cancer patient's responsiveness to anti-EGFR cancer drugs such as erlotinib based on the presence of one or more mutations in the MAPK1 genomic sequence. Related kits and therapeutic methods are also provided.

Abstract: The present invention relates to HPV-positive as well as HPV-negative screening platforms that are highly serum-dependent, for use as HNSCC models. These HNSCC models die reproducibly in serum-deprived conditions and the introduction of driver mutations (or increased levels of the WT gene) confers enhanced cell survival and proliferation under serum deprivation. These platforms have the major advantages of allowing functional screening of mutations in relevant HNSCC models (HPV-positive and HPV-negative). In addition to oncogene screening, this model can also be used in drug discovery. Specifically, cells expressing mutations that confer increased survival can then be screened against panels of therapeutic agents to determine if the mutation(s) can predict the optimal treatment for patients whose tumors harbor the mutation(s).

Abstract: A portable vacuumized container box which comprises a box body; the box body has a cavity and opens at its upper end; a top cover capable of fastening with the box body is provided at the upper end of the box body; air inlet hole and air outlet hole are disposed on the top cover; air inlet device is disposed on the air inlet hole; air outlet device is disposed on the air outlet hole; wherein the air outlet device comprises an air outlet piston, a piston fixing cover, and an air outlet valve coordinating with the air outlet piston to discharge air. The container box can be vacuumized by pulling up and pressing down the pull ring. The container box is very convenient for users to use, and it has good air discharging effect, good sealing ability and long service life.

Abstract: The present invention relates to HPV-positive as well as HPV-negative screening platforms that are highly serum-dependent, for use as HNSCC models. These HNSCC models die reproducibly in serum-deprived conditions and the introduction of driver mutations (or increased levels of the WT gene) confers enhanced cell survival and proliferation under serum deprivation. These platforms have the major advantages of allowing functional screening of mutations in relevant HNSCC models (HPV-positive and HPV-negative). In addition to oncogene screening, this model can also be used in drug discovery. Specifically, cells expressing mutations that confer increased survival can then be screened against panels of therapeutic agents to determine if the mutation(s) can predict the optimal treatment for patients whose tumors harbor the mutation(s).

Abstract: A vacuumized container box having a box body opened at its upper end and constructed in a shape of a container; a box cover is provided at the upper end of the box body; an air outlet opening is provided on the box cover; a vacuumizing device is provided on the air outlet opening for vacuumizing the box body; the vacuumizing device comprises a vacuum operation button and air pumps; the vacuum operation button is provided at an upper end of the box cover; the air pumps are actuated by the vacuum operation button and are provided at a bottom end of the box cover. Since the vacuumized container box is configured to incorporate the vacuumizing device, no other extra vacuumizing devices are required. The vacuumized container box is therefore convenient to use and attains good vacuumization.

Abstract: The present invention relates to stationery and more specifically pertains to a foldable magazine rack. It includes a rack body and a bottom panel removably fastened with a bottom end of the rack body; the rack body is a plastic rack which is foldable and integrally formed by injection molding. The present magazine rack is convenient to use, susceptible to low production costs, and can be repeatedly used.

Abstract: The present invention includes a hollow box body, a top cover and a bottom cover which are removably fastened with a top end and a bottom end of the box body respectively, and the box body is a plastic box body which is foldable and integrally formed by injection molding. The plastic box body has front and rear hard plastic walls which are symmetrical, and left and right hard plastic walls which are symmetrical; foldable soft plastic curved walls are disposed at intersections between the front, rear, left and right hard plastic walls. The storage box saves occupying space, and is susceptible to low production costs and has a simple structure. When in use, it is good in strength and securely fastened.

Abstract: A vacuumized container box having a box body opened at its upper end and constructed in a shape of a container; a box cover is provided at the upper end of the box body; an air outlet opening is provided on the box cover; a vacuumizing device is provided on the air outlet opening for vacuumizing the box body; the vacuumizing device comprises a vacuum operation button and air pumps; the vacuum operation button is provided at an upper end of the box cover; the air pumps are actuated by the vacuum operation button and are provided at a bottom end of the box cover. Since the vacuumized container box is configured to incorporate the vacuumizing device, no other extra vacuumizing devices are required. The vacuumized container box is therefore convenient to use and attains good vacuumization.

Abstract: A water-keeping assembly (109) for a plant container (110), which assembly (9) comprises a perforated partition (111) arranged to extend across the bottom of a said container (110) for dividing the interior of the container (110) into an upper compartment for holding therein soil and a lower compartment for collecting therein any water drained down from the soil through the partition (111). The assembly (109) includes ventilation tubes (112) arranged to extend upwards from the partition (111) so that air can reach from above into the lower compartment. The assembly (109) further includes water absorbent bars (113) arranged to pass from the lower compartment through the partition (111) into the upper half of the upper compartment for bringing water collected below the partition (111) upwards into the soil above the partition (111) through capillary action.