Patents by Inventor Tobias Gabriel

Tobias Gabriel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Btk protein kinase inhibitors
    Patent number: 7943618
    Abstract: This application discloses pyridine and pyrimidine compounds according to formula I wherein R1, R2, R3, R4, R5, X1 and A are as described herein which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of formula I and at least one carrier, diluent or excipient.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: May 17, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Nolan James Dewdney, Rama K. Kondru, Yan Lou, Michael Soth, Tobias Gabriel
  • Kinase inhibitors and methods for using the same
    Patent number: 7645764
    Abstract: Compounds of formula I: wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds, pharmaceutical compositions, methods of using the compounds for treatment of p38 MAP kinase-mediated diseases, and methods of using the compounds for treatment of Raf kinase-mediated diseases.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: January 12, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Tobias Gabriel, Joel McIntosh, Kin-Chun Thomas Luk
  • Substituted pyrazolo[3,4-D]pyrimidines as p38 MAP kinase inhibitors
    Patent number: 7608603
    Abstract: Compounds of formula Ia, Ib, Ic, Id, Ie, If, Ig or Ih: wherein X and Y are nitrogen or one of X and Y is nitrogen and the other is CRg, and W, D, E, R4, R5, R6 and Rg are as defined herein. Also disclosed are methods of making the subject compounds and methods of using the compounds in the treatment of p38 MAP kinase-mediated diseases.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: October 27, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Nolan James Dewdney, Tobias Gabriel, Kristen Lynn McCaleb
  • Substituted pyrazolo[3,4-d]pyrimidines as p38 MAP kinase inhibitors
    Patent number: 7601726
    Abstract: Compounds of formula Ia or Ib: wherein A, W, X, Y, R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: October 13, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Nidhi Arora, Nolan James Dewdney, Tobias Gabriel, Kristen Lynn McCaleb, Michael Soth
  • Substituted pyrazolo{3,4-D}pyrimidines as p38 map kinase inhibitors
    Patent number: 7566708
    Abstract: Compounds effective as p38 MAP kinase inhibitors, methods of making the compounds, and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: July 28, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Nidhi Arora, Roland Joseph Billedeau, Nolan James Dewdney, Tobias Gabriel, David Michael Goldstein, Counde O'Yang, Michael Soth, Teresa Alejandra Trejo-Martin
  • Substituted pyrazolo[3,4-D]pyrimidines as p38 map kinase inhibitors
    Patent number: 7563799
    Abstract: Compounds of the formula Ia or Ib: wherein X and Y are N or one of X and Y is N and the other is CRg, and A, D, E, G, W, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the subject compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: July 21, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Roland Joseph Billedeau, Nolan James Dewdney, Tobias Gabriel
  • Substituted pyrazolo[3,4-D]pyrimidines as p38 map kinase inhibitors
    Patent number: 7563800
    Abstract: Compounds of formula Ia or Ib: wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: July 21, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Tobias Gabriel, Yan Lou
  • BTK protein kinase inhibitors
    Publication number: 20090105209
    Abstract: This application discloses pyridine and pyrimidine compounds according to formula I wherein R1, R2, R3, R4, R5, X1 and A are as described herein which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of formula I and at least one carrier, diluent or excipient.
    Type: Application
    Filed: October 23, 2008
    Publication date: April 23, 2009
    Inventors: Nolan James Dewdney, Rama K. Kondru, Yan Lou, Michael Soth, Tobias Gabriel
  • p38 MAP kinase inhibitors and methods for using the same
    Patent number: 7517901
    Abstract: Compounds of formula Ia or Ib: wherein X and Y are nitrogen or CRe, and R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the subject compounds and methods of using the compounds for treatment of p38-mediated diseases.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: April 14, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Tobias Gabriel, Michael Soth
  • Indazole derivatives and methods for using the same
    Patent number: 7495015
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, k, B, R1, R2 and R3 are those defined herein, and compositions comprising the same. Also provided are methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a patient.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: February 24, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Nidhi Arora, Tobias Gabriel, David Michael Goldstein, Teresa Alejandra Trejo-Martin
  • Substituted pyrazolo [3,4-d] pyrimidines and methods of using the same
    Patent number: 7452880
    Abstract: Compounds of the formula I: where A, B, X, Y, Z, k, R1, R2 and R3 are those defined herein, and compositions comprising the same. The present invention also provides methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a patient.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: November 18, 2008
    Inventors: Nidhi Arora, Roland Joseph Billedeau, Nolan James Dewdney, Tobias Gabriel, David Michael Goldstein, Teresa Alejandra Trejo-Martin
  • Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same
    Patent number: 7435731
    Abstract: Compounds of the formula Ia or Ib: wherein A, B, X, Y, Z, W, k, R1, R2, R3, R4 and R5 are those defined herein, and compositions comprising the same. The present invention also provides methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a subject.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: October 14, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Nidhi Arora, Roland Joseph Billedeau, Nolan James Dewdney, Tobias Gabriel, David Michael Goldstein, Counde O'Yang, Michael Soth
  • Kinase inhibitors and methods for using the same
    Publication number: 20080207684
    Abstract: Compounds of formula I: wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Also disclosed are methods of making the compounds, pharmaceutical compositions, methods of using the compounds for treatment of disease associated with p38 MAP kinase.
    Type: Application
    Filed: February 27, 2008
    Publication date: August 28, 2008
    Inventors: Tobias Gabriel, Yan Lou
  • P38 map kinase inhibitors and methods for using the same
    Publication number: 20080146590
    Abstract: Compounds of formula Ia or Ib: wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
    Type: Application
    Filed: December 18, 2007
    Publication date: June 19, 2008
    Inventors: Tobias Gabriel, Yan Lou
  • Kinase inhibitors and methods for using the same
    Publication number: 20080132528
    Abstract: Compounds of formula I: wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds, pharmaceutical compositions, methods of using the compounds for treatment of p38 MAP kinase-mediated diseases, and methods of using the compounds for treatment of Raf kinase-mediated diseases.
    Type: Application
    Filed: November 8, 2007
    Publication date: June 5, 2008
    Inventors: Tobias Gabriel, Joel McIntosh, Kin-Chun Thomas Luk
  • Cathepsin K inhibitors
    Patent number: 7358373
    Abstract: The present invention provides a compound of the Formula: a pharmaceutically acceptable salt, a solvate, or a prodrug thereof, wherein m, n, Ar1, R1, R2, R3, R4, and R5 are those defined herein. The present invention also provides methods for using and preparing compounds of Formula I.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: April 15, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Joe Timothy Bamberg, Tobias Gabriel
  • Benzamide nitriles
    Patent number: 7300934
    Abstract: Compounds of the formula (I) wherein m, n, A, R1, R2, R3, R4, R5 and R6 are as described herein, together with methods for making the compounds and using the compounds for treatment of diseases or conditions mediated by Cathepsin K.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: November 27, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Tobias Gabriel, Nancy Elisabeth Krauss
  • p38 MAP kinase inhibitors and methods for using the same
    Publication number: 20070203160
    Abstract: Compounds effective as p38 MAP kinase inhibitors, methods of making the compounds, and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
    Type: Application
    Filed: August 23, 2006
    Publication date: August 30, 2007
    Inventors: Nidhi Arora, Roland Billedeau, Nolan Dewdney, Tobias Gabriel, David Goldstein, Counde O'Yang, Michael Soth, Teresa Trejo-Martin
  • p38 MAP kinase inhibitors and methods for using the same
    Publication number: 20070054915
    Abstract: Compounds of formula 1a or 1b: wherein A, W, X, Y, R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
    Type: Application
    Filed: August 23, 2006
    Publication date: March 8, 2007
    Inventors: Nidhi Arora, Humberto Arzeno, Roland Billedeau, Nolan Dewdney, Kieran Durkin, Tobias Gabriel, Kristen McCaleb, Michael Soth, Dennis Yasuda
  • p38 MAP kinase inhibitors and methods for using the same
    Publication number: 20070049633
    Abstract: Compounds of formula Ia or Ib: wherein X and Y are nitrogen or CRe, and R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the subject compounds and methods of using the compounds for treatment of p38-mediated diseases.
    Type: Application
    Filed: August 23, 2006
    Publication date: March 1, 2007
    Inventors: Tobias Gabriel, Michael Soth