Abstract: The technology disclosed relates to determining pathogenicity of variants. In particular, the technology disclosed relates to generating amino acid-wise distance channels for a plurality of amino acids in a protein. Each of the amino acid-wise distance channels has voxel-wise distance values for voxels in a plurality of voxels. A tensor includes the amino acid-wise distance channels and at least an alternative allele of the protein expressed by a variant. A deep convolutional neural network determines a pathogenicity of the variant based at least in part on processing the tensor. The technology disclosed further augments the tensor with supplemental information like a reference allele of the protein, evolutionary conservation data about the protein, annotation data about the protein, and structure confidence data about the protein.

Abstract: A housing for an electrical device comprises a housing bottom, a fastening element, and an unlocking element and is closeable by a housing cover. The housing bottom includes an elastically deformable connecting section to connect the housing to a machine, a technical system, or a building wall. The fastening element is disposed on an outer face of the connecting section and is connectable in a form-fitting and/or friction-fitting manner to a corresponding retaining element of the machine, the technical system, or the building wall. The unlocking element is disposed on an inner face of the connecting section and is operatively connected to the fastening element. The unlocking element is user actuatable only from an inside of the housing when the housing is open in order to release the form-fitting and/or friction-fitting connection of the fastening element to the retaining element of the machine, the technical system, or the building wall.

Abstract: Safety mat for safeguarding an electrically driven installation, comprising a sensor, a rigid supporting body and an evaluation unit. The supporting body has a top side, a rear side and first and second side faces, adjoining the top and rear sides. The sensor has an active surface covering the top side of the supporting body. The rear side has an opening for contacting an evaluation unit arranged in the interior of the supporting body that is configured to provide an output signal depending on the actuation of the sensor. The first side face has a first cavity and the second side face has a second cavity. The rear side has a first and a second cable guide. The first cable guide connects the opening to the first cavity and the second cable guide connects the opening to the second cavity.