Abstract: The invention relates to a transdermal therapeutic system, comprising a back layer that is impermeable to an active ingredient, a polymer matrix containing the active ingredient, and a protective layer that can be pulled off, wherein 5-aminolevulinic acid hydrochloride is used as the active ingredient and the basic polymer of the polymer matrix is an adhesive polyacrylate. Said transdermal therapeutic system is suitable for diagnosing and treating preliminary stages of skin cancer, such as actinic keratosis, and oncological skin diseases.

Abstract: The invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

Abstract: Systems, methods, and devices are provided to reduce a likelihood of image burn-in on an electronic display. Such an electronic device may include image processing circuitry and an electronic display. The image processing circuitry may receive image data and analyze the image data for risk of image burn-in and, based at least in part on the analysis of the image data, reduce a risk of image burn-in at least in part by reducing a local maximum pixel luminance value in at least one of a plurality of regions of the image data over time or by reducing a dynamic range headroom of the image data. The electronic display may display the image data with a reduced risk of image burn-in on the pixels of the electronic display.

Abstract: Devices, storage media, and methods for compensating for aging and temperature variations using dual-loop compensation are provided. The compensating for temperature and aging variations of one or more pixels of the display using a coarse scan loop updated at a faster rate. Compensation also includes compensating for aging variations of the one or more pixels of the display using a fine scan loop updated at a slower rate.

Abstract: Aspects of the subject technology relate to display circuitry including pixel overdrive circuitry. The pixel overdrive circuitry includes a compression engine that compresses a previous display frame, for storage and comparison to a current display frame without compression or decompression of the current display frame. The compression engine compresses the previous frame in such a way that the maximum compression error is always known and can be used to determine whether to perform overdrive operations for the current frame without compressing and decompressing the current display frame. The compression engine selects gradient encoding or decimation encoding for the compression of the previous display frame and can perform successive decimation operations within the gradient encoding operations to help reduce the size of the compressed previous frame while maintaining the quality of the ultimate overdriven current frame.

Abstract: An electronic device may be provided with a display. A content generator may generate frames of image data to be displayed on the display. Control circuitry in the electronic device may be used in implementing a tone mapping engine. The tone mapping engine may display content from the content generator on the display in accordance with a content-luminance-to-display luminance mapping. The content-luminance-to-display-luminance mapping is characterized by tone mapping parameters such as a black level, a reference white level, and a specular white level. The tone mapping engine may adjust the tone mapping parameters based on ambient light levels, user brightness settings, content statistics, and display characteristics.

Abstract: Systems, methods, and computer readable media to improve the operation of display systems are disclosed. In general, techniques are disclosed for dynamically adjusting backlight elements based on image content. More particularly, a backlight element's intensity may be targeted for boosting (i.e., increasing) based on content of the backlight element's corresponding image region, where after a check may be made to determine if the proposed increase is likely to risk generation of a halo. If the proposed intensity increase would risk a halo, the backlight element's proposed intensity may be dimmed. Repeating the boost/dim cycle in an iterative fashion permits an image to be displayed with brighter highlights and deeper blacks.

Abstract: Systems, methods, and computer readable media to improve the operation of display systems are described herein. In general, techniques are disclosed for ambient and content adaptive local tone mapping operations that improve display readability under bright ambient light conditions. More particularly, techniques disclosed herein improve contrast and brightness of dark image content while preserving bright areas. The disclosed architecture and operational methodologies generate high contrast images (e.g., amplifying dark regions while preserving bright content), preserve uniform backgrounds (e.g., static background pixels), are stabile in the face of local and global histogram changes (e.g., background not affected by small moving objects such as a mouse pointer), and provide near seamless fade-in and fad-out transitions.

Abstract: Devices, storage media, and methods for compensating for aging and temperature variations using dual-loop compensation are provided. The compensating for temperature and aging variations of one or more pixels of the display using a coarse scan loop updated at a faster rate. Compensation also includes compensating for aging variations of the one or more pixels of the display using a fine scan loop updated at a slower rate.

Abstract: A mobile electronic device includes a display having a pixel and processing circuitry separate from but communicatively coupled to the display. The processing circuitry prepares image data to send to the pixel and adjusts the image data to compensate for operational variations of the display based on feedback received from the display that describes a present operational behavior of the pixel. The mobile electronic device also includes additional electronic components that affect the present operational behavior of the pixel depending on present operational behavior of the additional electronic components.

Abstract: Methods, systems, and devices for improving contrast, dynamic range, and power consumption of a backlight in a display are provided. By way of example, a method includes receiving image data to be displayed on pixels of a display panel, generating a global histogram of the image data, generating a plurality of thresholds based on the global histogram, and defining a first threshold and a second threshold of the plurality of thresholds as local thresholds based on the global histogram and a local histogram. The first threshold and the second threshold are generated according to a local tone mapping function. The method further includes adjusting a luminance of one or more of pixels of the display panel based at least in part on the first threshold and the second threshold.

Abstract: Methods, systems, and devices for improving contrast, dynamic range, and power consumption of a backlight in a display are provided. By way of example, a method includes receiving image data to be displayed on pixels of a display panel, generating a global histogram of the image data, generating a plurality of thresholds based on the global histogram, and defining a first threshold and a second threshold of the plurality of thresholds as local thresholds based on the global histogram and a local histogram. The first threshold and the second threshold are generated according to a local tone mapping function. The method further includes adjusting a luminance of one or more of pixels of the display panel based at least in part on the first threshold and the second threshold.

Abstract: The invention relates to a transdermal therapeutic system, comprising a back layer that is impermeable to an active ingredient, a polymer matrix containing the active ingredient, and a protective layer that can be pulled off, wherein 5-aminolevulinic acid hydrochloride is used as the active ingredient and the basic polymer of the polymer matrix is an adhesive polyacrylate. Said transdermal therapeutic system is suitable for diagnosing and treating preliminary stages of skin cancer, such as actinic keratosis, and oncological skin diseases.

Abstract: A pharmaceutical dosage form for controlled release of the active substance 3-(2-dimethylaminomethylcyclohexyl)-phenol, preferably (1R,2R)-3-(2-dimethylaminomethylcyclohexyl)-phenol, or a pharmaceutically acceptable salt thereof, which dosage form (i) in vivo produces a peak plasma level of the active substance after 2 to 10 hours, and/or (ii) in vitro releases 3.0 to 37 percent by weight of the active substance originally contained in the dosage form after one-half hour, 5.0 to 56 percent by weight after one hour, 10 to 77 percent by weight after two hours, 15 to 88 percent by weight after 3 hours, at least 30 percent by weight after six hours, at least 50 percent by weight after 12 hours, at least 70 percent by weight after 18 hours, and at least 80 percent by weight after 24 hours when measured according to the European pharmacopoeia using a blade mixer in preferably 900 ml of a buffer solution at a pH value of 6.9, a temperature of 37° C., and 75 rpm.

Abstract: The present invention relates to a transdermal therapeutic system comprising at least one readily volatile and/or thermolabile active ingredient and/or auxiliary, which can be produced by laminating at least three components onto one another, namely a polymeric matrix layer, a likewise polymeric acceptor layer that absorbs the active ingredient and/or auxiliary at an increased rate, and a donor layer comprising, at the point of production, the volatile and/or thermolabile active ingredient and/or auxiliary. The system according to the invention is characterized in that, during or shortly after the lamination process, the donor layer combines with the acceptor layer as a result of migration of the readily volatile and/or thermolabile substances.

Abstract: The invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

Abstract: The invention relates to a dosage form for controlled release of the active ingredient 3-(2-dimethylaminomethylcyclohexyl)phenol, preferably (1R,2R)-3-(2-dimethylamino-methylcyclohexyl)phenol, or one of the pharmaceutically acceptable salts thereof, which (i) in vivo achieves the peak plasma level of the active ingredient after 2 to 10 h, and/or (ii) in vitro, measured in accordance with the European Pharmacopoeia with a paddle stirrer apparatus in buffer at a pH value of 6.8 (preferably 900 ml), a temperature of 37° C. and 75 rpm releases after 0.5 hours 3.0 to 37 wt. %, after 1 hour 5.0 to 56 wt. %, after 2 hours 10 to 77 wt. %, after 3 hours 15 to 88 wt. %, after 6 hours at least 30 wt. %, after 12 hours at least 50 wt. %, after 18 hours at least 70 wt. % and after 24 hours at least 80 wt. % of the active ingredient originally contained in the dosage form.

Abstract: The invention is directed to self-assembling, polymer-based delivery systems for proteins. The delivery systems comprises an active agent and a polyol ester of the invention, having a linear polyol containing six or more hydroxyl groups as a central backbone and biodegradable hydroxy carboxylic ester groups attached to the central backbone.

Abstract: The invention is directed to self-assembling, polymer-based delivery systems for proteins. The delivery systems comprises an active agent and a polyol ester of the invention, having a linear polyol containing six or more hydroxyl groups as a central backbone and biodegradable hydroxy carboxylic ester groups attached to the central backbone.