Abstract: The present invention relates to combinations of Regulator of telomere elongation helicase 1 (RTEL1) and Far Upstream Element-Binding Protein 1 (FUBP1) inhibitors, such as oligonucleotides (oligomers) that are complementary to RTEL1 or FUBP1, respectively, leading to modulation of the expression of RTEL1 and FUBP1 or modulation of RTEL1 and FUBP1 activity. The invention in particular relates to a combination of an inhibitor of RTEL1 and an inhibitor of FUBP1 for use in treating and/or preventing a disease, preferably a hepatitis B virus (HBV) infection, in particular a chronic HBV infection. The invention in particular relates to the use of a combination of RTEL1 and FUBP1 inhibitors for destabilizing cccDNA, such as HBV cccDNA. Also comprised in the present invention is a pharmaceutical composition, a kit and the use thereof in the treatment and/or prevention of a HBV infection.

Abstract: The present disclosure relates to a tumble dryer (1) with a filter arrangement (12) located in a tumble dryer process air flow (21) for removing lint from process air leaving tumble dryer drum. The filter arrangement comprises a first coarse-mesh filter (25) and a second fine filter (27). A first sensor (41) detects a correct positioning of the first filter in the tumble dryer, and a second sensor (33) detects a pressure drop over a process air flow path comprising the second filter. A control arrangement (45) is configured to initiate a disabling operation which disables the fan arrangement (12), if the first filter is not correctly positioned in the tumble dryer or if the pressure drop over the second filter exceeds a predetermined threshold value.

Abstract: Enhanced antisense oligonucleotides targeting Regulator of telomere elongation helicase 1 (RTEL1), leading to modulation of the expression of RTEL1 or modulation of RTEL1 activity are provided. This disclosure relates to the use of enhanced antisense oligonucleotides targeting RTEL1 for use in treating and/or preventing a hepatitis B virus (HBV) infection, in particular a chronic HBV infection. This disclosure further relates to the use of the enhanced antisense oligonucleotides targeting RTEL1 for destabilizing cccDNA, such as HBV cccDNA. A pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection is also described.

Abstract: The present disclosure provides antisense oligonucleotides targeting Regulator of telomere elongation helicase 1 (RTEL1). The disclosure also provides, enhanced antisense oligonucleotides targeting RTEL1 for use in treating and/or preventing a hepatitis B virus (HBV) infection. Also disclosed are pharmaceutical compositions and their use.

Abstract: The present invention relates to a laying machine for laying at least one flexible casing or tube, cable or wire including: a blade arrangement for making a trench in the ground, a consolidation and laying means being arranged behind the blade arrangement, for clearing and safe-guarding the trench from collapsing while laying at least one flexible casing or tube, cable or wire into the trench. A blade assembly comprising compartments for cooling fluid and air.

Abstract: Disclosed is a back-end system for emergency response, and a corresponding front-end system. The back-end system handles network communication to and/or from multiple information sources for gathering emergency response information from the information sources, including at least video data related to an emergency and/or security situation and additional emergency response information. The back-end system extracts subsets of information from the emergency response information at least partly based on input originating from one or more users and/or operators.

Abstract: Disclosed is a back-end system for emergency response, and a corresponding front-end system. The back-end system handles network communication to and/or from multiple information sources for gathering emergency response information from the information sources, including at least video data related to an emergency and/or security situation and additional emergency response information. The back-end system extracts subsets of information from the emergency response information at least partly based on input originating from one or more users and/or operators.

Abstract: Disclosed is a back-end system for emergency response, and a corresponding front-end system. The back-end system handles network communication to and/or from multiple information sources for gathering emergency response information from the information sources, including at least video data related to an emergency and/or security situation and additional emergency response information. The back-end system extracts subsets of information from the emergency response information at least partly based on input originating from one or more users and/or operators.

Abstract: A spacer structure (204; 205) for a saw disc assembly of a sawing machine (4), comprises a hub device (220) having a central axis and being adapted to be coaxially arranged between a pair of axially peripheral saw discs. According to the invention, said hub device (220) is configured and adapted to detachably or non-detachably receive a proximal portion (231) of an elongated spacer means (230) in a substantially radial manner in relation to said hub device, said elongated spacer means (230) being adapted to be arranged between said pair of saw discs, a distal portion (235) of said elongated spacer means (230) being constituted and adapted to detachably or non-detachably connect to said pair of peripheral saw discs.

Abstract: Enhanced antisense oligonucleotides targeting Regulator of telomere elongation helicase 1 (RTEL1), leading to modulation of the expression of RTEL1 or modulation of RTEL1 activity are provided. This disclosure relates to the use of enhanced antisense oligonucleotides targeting RTEL1 for use in treating and/or preventing a hepatitis B virus (HBV) infection, in particular a chronic HBV infection. This disclosure further relates to the use of the enhanced antisense oligonucleotides targeting RTEL1 for destabilizing cccDNA, such as HBV cccDNA. A pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection is also described.

Abstract: The present invention relates to a laying machine for laying at least one flexible casing or tube, cable or wire including: a blade arrangement for making a trench in the ground, a consolidation and laying means being arranged behind the blade arrangement, for clearing and safe-guarding the trench from collapsing while laying at least one flexible casing or tube, cable or wire into the trench. A blade assembly comprising compartments for cooling fluid and air.

Abstract: Disclosed is a back-end system for emergency response, and a corresponding front-end system. The back-end system handles network communication to and/or from multiple information sources for gathering emergency response information from the information sources, including at least video data related to an emergency and/or security situation and additional emergency response information. The back-end system extracts subsets of information from the emergency response information at least partly based on input originating from one or more users and/or operators.

Abstract: Disclosed is a back-end system for emergency response, and a corresponding front-end system. The back-end system handles network communication to and/or from multiple information sources for gathering emergency response information from the information sources, including at least video data related to an emergency and/or security situation and additional emergency response information. The back-end system extracts subsets of information from the emergency response information at least partly based on input originating from one or more users and/or operators.

Abstract: Disclosed is a back-end system for emergency response, and a corresponding front-end system. The back-end system handles network communication to and/or from multiple information sources for gathering emergency response information from the information sources, including at least video data related to an emergency and/or security situation and additional emergency response information. The back-end system extracts subsets of information from the emergency response information at least partly based on input originating from one or more users and/or operators.

Abstract: The present invention relates to a laying machine for laying at least one flexible casing or tube, cable or wire including: a blade arrangement for making a trench in the ground, a consolidation and laying means being arranged behind the blade arrangement, for clearing and safe-guarding the trench from collapsing while laying at least one flexible casing or tube, cable or wire into the trench. A blade assembly comprising compartments for cooling fluid and air.

Abstract: Disclosed is a back-end system for emergency response, and a corresponding front-end system. The back-end system handles network communication to and/or from multiple information sources for gathering emergency response information from the information sources, including at least video data related to an emergency and/or security situation and additional emergency response information. The back-end system extracts subsets of information from the emergency response information at least partly based on input originating from one or more users and/or operators.

Abstract: An abrasive disc (2) for grinding and/or polishing hard floor surfaces of stone, concrete or similar, the abrasive disc including a plurality of fixing means (3, 4) for mounting detachably mountable carrier plates (9), each with abrasive elements (11), to a grinding side (2a) of the abrasive disc (2), each carrier plate having a specific fixing geometry, characterized by that the fixing means are disposed at least two separate distances from the centre of the disc, first fixing means (3) at a first predetermined distance (r1) and second fixing means (4) at a second predetermined distance (r2), said second predetermined distance (r2) being shorter than the first (r1), so that the carrier plates (9) will be arranged in at least to rows, a first outer row and a second inner row, and each fixing mean (3, 4) includes a groove (7) providing a female coupling adapted for corresponding male couplings of the carrier plates (9).

Abstract: The present disclosure relates to a tumble dryer (1) with a filter arrangement (12) located in a tumble dryer process air flow (21) for removing lint from process air leaving tumble dryer drum. The filter arrangement comprises a first coarse-mesh filter (25) and a second fine filter (27). A first sensor (41) detects a correct positioning of the first filter in the tumble dryer, and a second sensor (33) detects a pressure drop over a process air flow path comprising the second filter. A control arrangement (45) is configured to initiate a disabling operation which disables the fan arrangement (12), if the first filter is not correctly positioned in the tumble dryer or if the pressure drop over the second filter exceeds a predetermined threshold value.

Abstract: Disclosed is a back-end system for emergency response, and a corresponding front-end system. The back-end system handles network communication to and/or from multiple information sources for gathering emergency response information from the information sources, including at least video data related to an emergency and/or security situation and additional emergency response information. The back-end system extracts subsets of information from the emergency response information at least partly based on input originating from one or more users and/or operators.

Abstract: The present invention relates to a laying machine for laying at least one flexible casing or tube, cable or wire including: a blade arrangement for making a trench in the ground, a consolidation and laying means being arranged behind the blade arrangement, for clearing and safe-guarding the trench from collapsing while laying at least one flexible casing or tube, cable or wire into the trench. A blade assembly comprising compartments for cooling fluid and air.