Patents by Inventor Tobias Ritter

Tobias Ritter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REAGENTS AND PROCESS FOR DIRECT C-H FUNCTIONALIZATION
    Publication number: 20230227425
    Abstract: The present invention refers to a process for direct C—H functionalization, the reagents used in the process and the use thereof for the direct C—H functionalization as well as the so-obtained products.
    Type: Application
    Filed: January 19, 2023
    Publication date: July 20, 2023
    Applicant: STUDIENGESELLSCHAFT KOHLE MBH
    Inventors: Tobias RITTER, Florian BERGER
  • Reagents and process for direct C—H functionalization
    Patent number: 11608322
    Abstract: The present invention refers to a process for direct C—H functionalization, the reagents used in the process and the use thereof for the direct C—H functionalization as well as the so-obtained products.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: March 21, 2023
    Assignee: STUDIENGESELLSCHAFT KOHLE MBH
    Inventors: Tobias Ritter, Florian Berger
  • REAGENT AND PROCESS FOR THE SITE-SPECIFIC DEOXYFLUORINATION OF PEPTIDES
    Publication number: 20220073552
    Abstract: The present invention refers to reagents and methods for preparing a peptide sequence having a [18F]fluoro-aromatic amino acid side which may be further substituted, in particular a 4-[18F]fluoro-phenylalanine side chain in peptide sequences, by chemoselective radio-deoxyfluorination of an aromatic amino acid residue, in particular a tyrosine residue using a traceless-activating group and the reagents used in said process.
    Type: Application
    Filed: July 3, 2019
    Publication date: March 10, 2022
    Applicant: STUDIENGESELLSCHAFT KOHLE MBH
    Inventors: Tobias RITTER, Henrick Jens RICKMEIER
  • REAGENTS AND PROCESS FOR DIRECT C-H FUNCTIONALIZATION
    Publication number: 20220002263
    Abstract: The present invention refers to a process for direct C—H functionalization, the reagents used in the process and the use thereof for the direct C—H functionalization as well as the so-obtained products.
    Type: Application
    Filed: November 5, 2019
    Publication date: January 6, 2022
    Applicant: STUDIENGESELLSCHAFT KOHLE MBH
    Inventors: Tobias RITTER, Florian BERGER
  • Direct palladium-catalyzed aromatic fluorination
    Patent number: 11179710
    Abstract: Provided herein are palladium complexes comprising a ligand of Formula (A?) and a ligand of Formula (B), wherein R1-R18 are as defined herein. The palladium complexes are useful in methods of fluorinating aryl and heteroaryl substrates. Further provided are compositions and kits comprising the palladium complexes.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: November 23, 2021
    Assignees: President and Fellows of Harvard College, Studiengesellschaft Kohle mbH
    Inventors: Tobias Ritter, Jeffrey Garber, Kumiko Yamamoto
  • Process for deoxyfluorination of phenols
    Patent number: 11046628
    Abstract: The present invention refers to a process for transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for positron emission tomography (PET) imaging.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: June 29, 2021
    Assignee: STUDIENGESELLSCHAFT KOHLE MBH
    Inventors: Tobias Ritter, Constanze Neumann, Mohammad Hassan Beyzavi, Martin Georg Strebl-Bantillo, Debashis Mandal
  • Process for hydrocyanation of terminal alkynes
    Patent number: 10947186
    Abstract: The present invention refers to a process for a Rh-catalyzed Anti-Markovnikov hydrocyanation of terminal alkynes which process discloses, for the first time, the highly stereo- and regio-selective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles and the catalyst used in the present process.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: March 16, 2021
    Assignee: STUDIENGESELLSCHAFT KOHLE MBH
    Inventors: Tobias Ritter, Fei Ye
  • PROCESS FOR DEOXYFLUORINATION OF PHENOLS
    Publication number: 20200369583
    Abstract: The present invention refers to a process for transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for positron emission tomography (PET) imaging.
    Type: Application
    Filed: July 10, 2018
    Publication date: November 26, 2020
    Applicants: STUDIENGESELLSCHAFT KOHLE MBH, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Tobias RITTER, Constanze NEUMANN, Mohammad Hassan BEYZAVI, Martin Georg STREBL-BANTILLO, Debashis MANDAL
  • Fluorination of organic compounds
    Patent number: 10759764
    Abstract: Methods for fluorinating organic compounds utilizing a novel organic reagent are described herein. The invention further discloses the utility of this reagent for incorporation of the 18 F isotope into hydroxyl group-containing organic molecules for PET imaging studies. Preparation of the reagents is described along with isolable intermediate structures from reaction of the reagent with a hydroxyl group-containing organic molecule.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: September 1, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Tobias Ritter, Constanze Nicole Neumann
  • PROCESS FOR HYDROCYANATION OF TERMINAL ALKYNES
    Publication number: 20200181068
    Abstract: The present invention refers to a process for a Rh-catalyzed Anti-Markovnikov hydrocyanation of terminal alkynes which process discloses, for the first time, the highly stereo- and regio-selective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles and the catalyst used in the present process.
    Type: Application
    Filed: May 8, 2018
    Publication date: June 11, 2020
    Applicant: STUDIENGESELLSCHAFT KOHLE MBH
    Inventors: Tobias RITTER, Fei YE
  • DIRECT PALLADIUM-CATALYZED AROMATIC FLUORINATION
    Publication number: 20190099748
    Abstract: Provided herein are palladium complexes comprising a ligand of Formula (A?) and a ligand of Formula (B), wherein R1-R18 are as defined herein. The palladium complexes are useful in methods of fluorinating aryl and heteroaryl substrates. Further provided are compositions and kits comprising the palladium complexes.
    Type: Application
    Filed: March 9, 2017
    Publication date: April 4, 2019
    Applicants: President and Fellows of Harvard College, Studiengesellschaft Kohle mbH
    Inventors: Tobias Ritter, Jeffrey Garber, Kumiko Yamamoto
  • IRON COMPLEXES AND METHODS FOR POLYMERIZATION
    Publication number: 20160272742
    Abstract: Provided are methods of preparing polymers, such as polyisoprene, polybutadiene, polypiperylene, polycyclohexadiene, poly-?-farnesene, or poly-?-myrcene, using iron complexes. Also provided are novel iron complexes, pre-catalysts, intermediates, and ligands useful in the inventive polymerization system.
    Type: Application
    Filed: March 22, 2016
    Publication date: September 22, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Tobias Ritter, Jean B. Raynaud, Jessica Yung Wu
  • FLUORINATION OF ORGANIC COMPOUNDS
    Publication number: 20160272593
    Abstract: Methods for fluorinating organic compounds utilizing a novel organic reagent are described herein. The invention further discloses the utility of this reagent for incorporation of the 18 F isotope into hydroxyl group-containing organic molecules for PET imaging studies. Preparation of the reagents is described along with isolable intermediate structures from reaction of the reagent with a hydroxyl group-containing organic molecule.
    Type: Application
    Filed: October 17, 2014
    Publication date: September 22, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Tobias Ritter, Constanze Nicole Neumann
  • Iron complexes and methods for polymerization
    Patent number: 9290591
    Abstract: Provided are methods of preparing polymers, such as polyisoprene, polybutadiene, polypiperylene, polycyclohexadiene, poly-?-farnesene, or poly-?-myrcene, using iron complexes. Also provided are novel iron complexes, pre-catalysts, intermediates, and ligands useful in the inventive polymerization system.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: March 22, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Tobias Ritter, Jean B. Raynaud, Jessica Yung Wu
  • Nickel fluorinating complexes and uses thereof
    Patent number: 9273083
    Abstract: The present invention provides novel nickel complexes. These complexes are in providing fluorinating organic compounds. The invention is particularly useful for fluorinating compounds with 18 F for PET imaging.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: March 1, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Tobias Ritter, Eunsung Lee
  • PLATINUM METALLACYCLES COMPRISING N, P, OR AS RINGATOMS AND THEIR USE AS CATALYSTS IN 1,2-HYDROSILYLATION REACTIONS OF DIENES
    Publication number: 20160009747
    Abstract: Described herein are platinum complexes of Formula (I) for hydrosilylation of 1,3-dienes. Methods of using the platinum complexes for selective 1,2-hydrosilylation of 1,3-dienes are also provided.
    Type: Application
    Filed: March 4, 2014
    Publication date: January 14, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Sarah E. PARKER, Tobias RITTER
  • Fluorination of organic compounds
    Patent number: 9150516
    Abstract: Methods for fluorinating organic compounds are described herein.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: October 6, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Tobias Ritter, Pingping Tang
  • NICKEL FLUORINATING COMPLEXES AND USES THEREOF
    Publication number: 20150252067
    Abstract: The present invention provides novel nickel complexes. These complexes are in providing fluorinating organic compounds. The invention is particularly useful for fluorinating compounds with 18F for PET imaging.
    Type: Application
    Filed: September 26, 2013
    Publication date: September 10, 2015
    Applicant: President and Fellows of Harvard College
    Inventors: Tobias Ritter, Eunsung Lee
  • Fluorination of organic compounds
    Patent number: 9024093
    Abstract: Methods for fluorinating organic compounds are described herein.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: May 5, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Tobias Ritter, Takeru Furuya, Pingping Tang
  • High-valent palladium fluoride complexes and uses thereof
    Patent number: 8686158
    Abstract: The present invention provides novel high-valent palladium fluoride complexes. The complexes typically include multi-dentate ligands that stabilize the octahedral coordination sphere of the palladium(IV) atom. These complexes are useful in fluorinating organic compounds, in particular aryl-containing compounds. The invention is particularly useful for fluorinating compounds with 19F for PET imaging.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: April 1, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: Takeru Furuya, David Powers, Tobias Ritter