Patents by Inventor Toby Matthew Grover Mullins

Toby Matthew Grover Mullins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aza-heterocyclyl carboxamide and related compounds and their use in treating medical conditions
    Patent number: 12227475
    Abstract: The invention provides aza-heterocyclyl carboxamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as bacterial infections, and in inhibiting LpxC activity.
    Type: Grant
    Filed: April 27, 2022
    Date of Patent: February 18, 2025
    Inventors: Michael Dominic Ryan, Thomas David Pallin, Toby Jonathan Blench, Toby Matthew Grover Mullins, David Edward Clark, Emanuela Gancia, Nadia Mamoona Ahmad
  • TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS
    Publication number: 20240391936
    Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.
    Type: Application
    Filed: March 25, 2022
    Publication date: November 28, 2024
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Laura CARZANIGA, Andrea RIZZI, Nicoió IOTTI, Fabio RANCATI, Anna KARAWAJCZYK, Barbara Karolina WOLEK, David Edward CLARK, Toby Matthew Grover MULLINS, Keith Christopher KNIGHT, Ben Paul WHITTAKER, Stefano LEVANTO
  • PHTHALAZINONE BASED MODULATORS FOR THE TREATMENT OF DISEASE
    Publication number: 20240374589
    Abstract: The disclosure herein provides compounds and pharmaceutical compositions of Formula (I), (II), (III), (IV), (V), or (VI) for killing cancer cell or inhibiting cancer cell proliferation. Further, the compounds and pharmaceutical compositions of Formula (I), (II), (III), (IV), (V), or (VI) are useful in methods of for the inhibition of cancer cell proliferation.
    Type: Application
    Filed: July 11, 2024
    Publication date: November 14, 2024
    Inventors: Nadia Mamoona AHMAD, Christopher Charles RENNIE, William Rameshchandra Krishna ESMIEU, Mark CHAMBERS, Toby Jonathan BLENCH, Susan Mary CRAMP, Toby Matthew Grover MULLINS, Terry Aaron PANCHAL, Joseph Leo MCKENNA
  • INDOLINE DERIVATIVES AS DDRS INHIBITORS
    Publication number: 20240217967
    Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.
    Type: Application
    Filed: March 25, 2022
    Publication date: July 4, 2024
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Laura CARZANIGA, Fabio RANCATI, Andrea RIZZI, Nicolò IOTTI, Keith Christopher KNIGHT, Toby Matthew Grover MULLINS, Anna KARAWAJCZYK, Ben Paul WHITTAKER
  • TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS
    Publication number: 20240199635
    Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.
    Type: Application
    Filed: March 25, 2022
    Publication date: June 20, 2024
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Laura CARZANIGA, Fabio RANCATI, Andrea RIZZi, Keith Christopher KNIGHT, Anna KARAWAJCZYK, Barbara Karolina WOLEK, Toby Matthew Grover MULLINS, Ben Paul WHITTAKER
  • INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS
    Publication number: 20240190847
    Abstract: The present invention relates to compounds of general formula (I) inhibiting DDR1 and DDR2. Particularly, the invention relates to compounds that are indoline derivatives, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of DDRs, in particular fibrosis.
    Type: Application
    Filed: March 25, 2022
    Publication date: June 13, 2024
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Laura CARZANIGA, Fabio RANCATI, Andrea RIZZI, Anna KARAWAJCZYK, Barbara Karolina WOLEK, Toby Matthew Grover MULLINS
  • AZA-HETEROCYCLYL CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS
    Publication number: 20230139502
    Abstract: The invention provides aza-heterocyclyl carboxamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as bacterial infections, and in inhibiting LpxC activity.
    Type: Application
    Filed: April 27, 2022
    Publication date: May 4, 2023
    Inventors: Michael Dominic Ryan, Thomas David Pallin, Toby Jonathan Blench, Toby Matthew Grover Mullins, David Edward Clark, Emanuela Gancia, Nadia Mamoona Ahmad