Patents by Inventor Tod Dwayne Strugnell

Tod Dwayne Strugnell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of optimizing nucleotide sequences encoding engineered influenza proteins
    Patent number: 11827668
    Abstract: The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
    Type: Grant
    Filed: July 19, 2022
    Date of Patent: November 28, 2023
    Assignee: SANOFI PASTEUR INC.
    Inventors: Tod Dwayne Strugnell, Guadalupe Cortes-Garcia, Tim Alefantis
  • METHODS OF OPTIMIZING NUCLEOTIDE SEQUENCES ENCODING ENGINEERED INFLUENZA PROTEINS
    Publication number: 20220363724
    Abstract: The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
    Type: Application
    Filed: July 19, 2022
    Publication date: November 17, 2022
    Inventors: Tod Dwayne Strugnell, Guadalupe Cortes-Garcia, Tim Alefantis
  • Methods of optimizing nucleotide sequences encoding engineered influenza proteins
    Patent number: 11427619
    Abstract: The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: August 30, 2022
    Assignee: SANOFI PASTEUR INC.
    Inventors: Tod Dwayne Strugnell, Guadalupe Cortes-Garcia, Tim Alefantis
  • METHODS OF OPTIMIZING NUCLEOTIDE SEQUENCES ENCODING ENGINEERED INFLUENZA PROTEINS
    Publication number: 20210130416
    Abstract: The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
    Type: Application
    Filed: January 12, 2021
    Publication date: May 6, 2021
    Inventors: Tod Dwayne Strugnell, Guadalupe Cortes-Garcia, Tim Alefantis
  • Methods of optimizing nucleotide sequences encoding engineered influenza proteins
    Patent number: 10927151
    Abstract: The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: February 23, 2021
    Assignee: SANOFI PASTEUR INC.
    Inventors: Tod Dwayne Strugnell, Guadalupe Cortes-Garcia, Tim Alefantis
  • METHODS OF OPTIMIZING NUCLEOTIDE SEQUENCES ENCODING ENGINEERED INFLUENZA PROTEINS
    Publication number: 20180162914
    Abstract: The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.
    Type: Application
    Filed: June 9, 2016
    Publication date: June 14, 2018
    Inventors: Tod Dwayne Strugnell, Guadalupe Cortes-Garcia, Tim Alefantis