Patents by Inventor Tod M. Klingler

Tod M. Klingler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200105413
    Abstract: Methods and systems for performing a clinical prediction are provided. In one example, the method comprises: receiving first molecular data of a patient, the first molecular data including at least gene expressions of the patient; receiving first biopsy image data of the patient; processing, using a machine learning model, the first molecular data and the first biopsy image data to perform a clinical prediction of the patient's response to a treatment, wherein the machine learning model is generated or updated based on second molecular data including at least gene expressions and second biopsy image data of a plurality of patients; and generating an output of the clinical prediction.
    Type: Application
    Filed: September 30, 2019
    Publication date: April 2, 2020
    Inventors: Antoaneta Petkova VLADIMIROVA, Yogesh P. PANDIT, Vishakha SHARMA, Tod M. KLINGLER, Hari SINGHAL
  • Publication number: 20100136564
    Abstract: The invention relates to methods useful for diagnosing and monitoring the steroid responsiveness of a subject by detecting expression of steroid modulated genes and for predicting transplant rejection and non-rejection.
    Type: Application
    Filed: November 30, 2009
    Publication date: June 3, 2010
    Applicant: XDx, Inc.
    Inventors: Preeti LAL, Steven Rosenberg, Tod M. Klingler
  • Patent number: 6742004
    Abstract: Disclosed is a relational database system for storing and manipulating biomolecular sequence information, the database including genomic libraries for a plurality of types of organisms, the libraries having multiple genomic sequences, at least some of which represent open reading frames located along a contiguous sequence on each the plurality of organisms' genomes, and a user interface capable of receiving a selection of two or more of the genomic libraries for comparison and displaying the results of the comparison. The system also provides a user interface capable of receiving a selection of one or more probe open reading frames for use in determining homologous matches between such probe open reading frame(s) and the open reading frames in the genomic libraries, and displaying the results of the determination.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: May 25, 2004
    Assignee: Incyte Genomics, Inc.
    Inventors: Cathryn E. Sabatini, Joe Don Heath, Peter A. Covitz, Tod M. Klingler, Frank D. Russo, Stephanie F. Berry
  • Publication number: 20040024535
    Abstract: The present invention provides relational database systems for storing biomolecular sequence information together with biological annotations detailing the source of the sequence information, and associated reagent information. The acquisition, storage and access of reagent information associated with databased biomolecular sequence information is a particular advantage of the present invention. Such reagent information identifies genetic information and materials which may be made available to a user of the relational database system of the present invention for further application in research, therapeutic pharmaceutical development or other fields. The reagent information aspect of the present invention is preferably used in conjunction with a biomolecular sequence relational database system.
    Type: Application
    Filed: February 4, 2003
    Publication date: February 5, 2004
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Stephen E. Lincoln, Tod M. Klingler, Landes C. Wong, Scott R. Panzer, David M. Hodgson, Laura Y. Ito, Andrew D. Ament, Richard Cathcart, Helen E. Jolley, Ingrid E. Akerblom, Brian M. McKelligon, Mayank K. Thanawala
  • Publication number: 20030181706
    Abstract: The invention provides compositions and novel polynucleotides and proteins that co-express with known marker genes for inflammatory disorders. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of inflammatory disorders.
    Type: Application
    Filed: May 16, 2003
    Publication date: September 25, 2003
    Applicant: Incyte Corporation
    Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler
  • Publication number: 20030175795
    Abstract: The invention provides compositions and novel polynucleotides and their encoded proteins that serve as surrogate markers in that they co-express with genes known to be involved associated with disorders associated with cardiac muscle function. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of disorders associated with cardiac muscle function.
    Type: Application
    Filed: April 29, 2003
    Publication date: September 18, 2003
    Applicant: Incyte Corporation
    Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler, Yalda Azimzai
  • Publication number: 20030158085
    Abstract: The invention provides a mammalian cDNA which encodes a mammalian AQP8V. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of pancreatic disorders, particularly type I diabetes. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
    Type: Application
    Filed: March 24, 2003
    Publication date: August 21, 2003
    Applicant: Incyte Corporation
    Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler
  • Patent number: 6602667
    Abstract: The invention provides compositions and novel polynucleotides and proteins that co-express with known marker genes for inflammatory disorders. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of inflammatory disorders.
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: August 5, 2003
    Assignee: Incyte Corporation
    Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler
  • Patent number: 6553317
    Abstract: The present invention provides relational database systems for storing biomolecular sequence information together with biological annotations detailing the source of the sequence information, and associated reagent information. The acquisition, storage and access of reagent information associated with databased biomolecular sequence information is a particular advantage of the present invention. Such reagent information identifies genetic information and materials which may be made available to a user of the relational database system of the present invention for further application in research, therapeutic pharmaceutical development or other fields. The reagent information aspect of the present invention is preferably used in conjunction with a biomolecular sequence relational database system.
    Type: Grant
    Filed: March 4, 1998
    Date of Patent: April 22, 2003
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Stephen E. Lincoln, Tod M. Klingler, Landes C. Wong, Scott R. Panzer, David M. Hodgson, Laura Y. Ito, Andrew D. Ament, Richard Cathcart, Helen E. Jolley, Ingrid E. Akerblom, Brian M. McKelligon, Mayank K. Thanawala
  • Publication number: 20030009296
    Abstract: Disclosed is a relational database system for storing and manipulating biomolecular sequence information, the database including genomic libraries for a plurality of types of organisms, the libraries having multiple genomic sequences, at least some of which represent open reading frames located along a contiguous sequence on each the plurality of organisms' genomes, and a user interface capable of receiving a selection of two or more of the genomic libraries for comparison and displaying the results of the comparison. The system also provides a user interface capable of receiving a selection of one or more probe open reading frames for use in determining homologous matches between such probe open reading frame(s) and the open reading frames in the genomic libraries, and displaying the results of the determination.
    Type: Application
    Filed: March 15, 2002
    Publication date: January 9, 2003
    Applicant: Incyte Genomics, Inc.
    Inventors: Cathryn E. Sabatini, Joe Don Heath, Peter A. Covitz, Tod M. Klingler, Frank D. Russo, Stephanie F. Berry
  • Publication number: 20020077309
    Abstract: The invention provides compositions and novel polynucleotides and their encoded proteins that co-express with genes involved in insulin synthesis and known to be associated with pancreatic disorders. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of pancreatic disorders.
    Type: Application
    Filed: May 23, 2001
    Publication date: June 20, 2002
    Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler
  • Publication number: 20020077470
    Abstract: The invention provides compositions and novel polynucleotides and their encoded proteins that serve as surrogate markers in that they co-express with genes known to be involved associated with disorders associated with cardiac muscle function. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of disorders associated with cardiac muscle function.
    Type: Application
    Filed: June 12, 2001
    Publication date: June 20, 2002
    Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler, Yalda Azimzai
  • Publication number: 20020064792
    Abstract: The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
    Type: Application
    Filed: September 19, 2001
    Publication date: May 30, 2002
    Inventors: Stephen E. Lincoln, Tod M. Klingler, Janice Au-Young, Y. Tom Tang, Richard D. Goold, Ingrid E. Akerblom, Jeffrey J. Seilhamer, Phillip R. Hawkins, Lynn E. Murry, Angelo M. Delegeane, Wendy B. Levine, Jennifer L. Hillman, Surya K. Goli, Christina M. Altus, Olga Bandman, Samuel T. LaBrie, Purvi Shah
  • Patent number: 6389428
    Abstract: A computer system stores biomolecular data in a database in a memory. The biomolecular database has a set of entities. Each entity stores attributes for a plurality of entries. At least one attribute is stored in an array. Data associated with an entry is stored at a location in the array. An entity offset designates the location of the data in the array. The same entity offset value is used to access data associated with a particular entry for all attributes within the entity.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: May 14, 2002
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Philippe E. Rigault, Anne L. Curtis, Richard D. Goold, David A. Hadley, Harold H. Hibbert, Tod M. Klingler, Robert E. Lagace, Laura L. Stuve, Michael G. Walker, Michael P. Wood
  • Publication number: 20020042680
    Abstract: A computer system stores biomolecular data in a database in a memory. The biomolecular database has a set of entities. Each entity stores attributes for a plurality of entries. At least one attribute is stored in an array. Data associated with an entry is stored at a location in the array. An entity offset designates the location of the data in the array. The same entity offset value is used to access data associated with a particular entry for all attributes within the entity.
    Type: Application
    Filed: April 11, 2001
    Publication date: April 11, 2002
    Inventors: Philippe E. Rigault, Anne L. Curtis, Richard D. Goold, David A. Hadley, Harold H. Hibbert, Tod M. Klingler, Robert E. Lagace, Laura L. Stuve, Michael G. Walker, Michael P. Wood
  • Publication number: 20020019000
    Abstract: The invention provides compositions, polynucleotides and proteins that coexpress with known matrix-remodeling genes. The invention also provides expression vectors and host cells, and ligands and antibodies which specifically bind the proteins. The invention also relates to the use of these biomolecules in diagnosis, prognosis, prevention, treatment, and evaluation of therapies for diseases associated with matrix-remodeling.
    Type: Application
    Filed: March 26, 2001
    Publication date: February 14, 2002
    Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler
  • Patent number: 6303297
    Abstract: The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: October 16, 2001
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Steve E. Lincoln, Tod M. Klingler, Janice Au-Young, Y. Tom Tang, Richard D. Goold, Ingrid E. Akerblom, Jeffrey J. Seilhamer, Phillip R. Hawkins, Lynn E. Murry, Angelo M. Delegeane, Wendy B. Levine, Jennifer L. Hillman, Surya K. Goli, Christina M. Altus, Olga Bandman, Samuel T. LaBrie, Purvi Shah
  • Patent number: 6277574
    Abstract: The invention provides novel kidney disease-associated genes and polypeptides encoded by those genes. The invention also provides expression vectors, host cells, and antibodies. The invention also provides methods for diagnosing, treating or preventing diseases of the kidney.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: August 21, 2001
    Assignee: Incyte Genomics, Inc.
    Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler, Yalda Azimzai, Henry Yue
  • Patent number: 6223186
    Abstract: A computer system stores biomolecular data in a database in a memory. The biomolecular database has a set of entities. Each entity stores attributes for a plurality of entries. At least one attribute is stored in an array. Data associated with an entry is stored at a location in the array. An entity offset designates the location of the data in the array. The same entity offset value is used to access data associated with a particular entry for all attributes within the entity.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: April 24, 2001
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Philippe E. Rigault, Anne L. Curtis, Richard D. Goold, David A. Hadley, Harold H. Hibbert, Tod M. Klingler, Robert E. Lagace, Laura L. Stuve, Michael G. Walker, Michael P. Wood
  • Patent number: 6023659
    Abstract: Disclosed is a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to one or more protein function hierarchies. The hierarchies allow searches for sequences based upon a protein's biological function or molecular function. Also disclosed is a mechanism for automatically grouping new sequences into protein function hierarchies. This mechanism uses descriptive information obtained from "external hits" which are matches of stored sequences against gene sequences stored in an external database such as GenBank. The descriptive information provided with the external database is evaluated according to a specific algorithm and used to automatically group the external hits (or the sequences associated with the hits) in the categories.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: February 8, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jeffrey J. Seilhamer, Ingrid E. Akerblom, Christina M. Altus, Tod M. Klingler, Frank Russo, Janice Au-Young, Jennifer L. Hillman, Timothy J. Maslyn