Patents by Inventor Tod M. Klingler
Tod M. Klingler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230029915Abstract: Methods and systems for performing a clinical prediction are provided. In one example, the method comprises: receiving first molecular data of a patient, the first molecular data including at least gene expressions of the patient; receiving first biopsy image data of the patient; processing, using a machine learning model, the first molecular data and the first biopsy image data to perform a clinical prediction of the patient's response to a treatment, wherein the machine learning model is generated or updated based on second molecular data including at least gene expressions and second biopsy image data of a plurality of patients; and generating an output of the clinical prediction.Type: ApplicationFiled: August 16, 2022Publication date: February 2, 2023Applicant: Roche Molecular Systems, Inc.Inventors: Antoaneta Petkova Vladimirova, Yogesh P. Pandit, Vishakha Sharma, Tod M. Klingler, Hari Singhal
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Patent number: 11462325Abstract: Methods and systems for performing a clinical prediction are provided. In one example, the method comprises: receiving first molecular data of a patient, the first molecular data including at least gene expressions of the patient; receiving first biopsy image data of the patient; processing, using a machine learning model, the first molecular data and the first biopsy image data to perform a clinical prediction of the patient's response to a treatment, wherein the machine learning model is generated or updated based on second molecular data including at least gene expressions and second biopsy image data of a plurality of patients; and generating an output of the clinical prediction.Type: GrantFiled: September 30, 2019Date of Patent: October 4, 2022Assignee: Roche Molecular Systems, Inc.Inventors: Antoaneta Petkova Vladimirova, Yogesh P. Pandit, Vishakha Sharma, Tod M. Klingler, Hari Singhal
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Publication number: 20200105413Abstract: Methods and systems for performing a clinical prediction are provided. In one example, the method comprises: receiving first molecular data of a patient, the first molecular data including at least gene expressions of the patient; receiving first biopsy image data of the patient; processing, using a machine learning model, the first molecular data and the first biopsy image data to perform a clinical prediction of the patient's response to a treatment, wherein the machine learning model is generated or updated based on second molecular data including at least gene expressions and second biopsy image data of a plurality of patients; and generating an output of the clinical prediction.Type: ApplicationFiled: September 30, 2019Publication date: April 2, 2020Inventors: Antoaneta Petkova VLADIMIROVA, Yogesh P. PANDIT, Vishakha SHARMA, Tod M. KLINGLER, Hari SINGHAL
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Publication number: 20100136564Abstract: The invention relates to methods useful for diagnosing and monitoring the steroid responsiveness of a subject by detecting expression of steroid modulated genes and for predicting transplant rejection and non-rejection.Type: ApplicationFiled: November 30, 2009Publication date: June 3, 2010Applicant: XDx, Inc.Inventors: Preeti LAL, Steven Rosenberg, Tod M. Klingler
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Patent number: 6742004Abstract: Disclosed is a relational database system for storing and manipulating biomolecular sequence information, the database including genomic libraries for a plurality of types of organisms, the libraries having multiple genomic sequences, at least some of which represent open reading frames located along a contiguous sequence on each the plurality of organisms' genomes, and a user interface capable of receiving a selection of two or more of the genomic libraries for comparison and displaying the results of the comparison. The system also provides a user interface capable of receiving a selection of one or more probe open reading frames for use in determining homologous matches between such probe open reading frame(s) and the open reading frames in the genomic libraries, and displaying the results of the determination.Type: GrantFiled: March 15, 2002Date of Patent: May 25, 2004Assignee: Incyte Genomics, Inc.Inventors: Cathryn E. Sabatini, Joe Don Heath, Peter A. Covitz, Tod M. Klingler, Frank D. Russo, Stephanie F. Berry
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Publication number: 20040024535Abstract: The present invention provides relational database systems for storing biomolecular sequence information together with biological annotations detailing the source of the sequence information, and associated reagent information. The acquisition, storage and access of reagent information associated with databased biomolecular sequence information is a particular advantage of the present invention. Such reagent information identifies genetic information and materials which may be made available to a user of the relational database system of the present invention for further application in research, therapeutic pharmaceutical development or other fields. The reagent information aspect of the present invention is preferably used in conjunction with a biomolecular sequence relational database system.Type: ApplicationFiled: February 4, 2003Publication date: February 5, 2004Applicant: Incyte Pharmaceuticals, Inc.Inventors: Stephen E. Lincoln, Tod M. Klingler, Landes C. Wong, Scott R. Panzer, David M. Hodgson, Laura Y. Ito, Andrew D. Ament, Richard Cathcart, Helen E. Jolley, Ingrid E. Akerblom, Brian M. McKelligon, Mayank K. Thanawala
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Publication number: 20030181706Abstract: The invention provides compositions and novel polynucleotides and proteins that co-express with known marker genes for inflammatory disorders. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of inflammatory disorders.Type: ApplicationFiled: May 16, 2003Publication date: September 25, 2003Applicant: Incyte CorporationInventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler
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Publication number: 20030175795Abstract: The invention provides compositions and novel polynucleotides and their encoded proteins that serve as surrogate markers in that they co-express with genes known to be involved associated with disorders associated with cardiac muscle function. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of disorders associated with cardiac muscle function.Type: ApplicationFiled: April 29, 2003Publication date: September 18, 2003Applicant: Incyte CorporationInventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler, Yalda Azimzai
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Publication number: 20030158085Abstract: The invention provides a mammalian cDNA which encodes a mammalian AQP8V. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of pancreatic disorders, particularly type I diabetes. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.Type: ApplicationFiled: March 24, 2003Publication date: August 21, 2003Applicant: Incyte CorporationInventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler
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Patent number: 6602667Abstract: The invention provides compositions and novel polynucleotides and proteins that co-express with known marker genes for inflammatory disorders. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of inflammatory disorders.Type: GrantFiled: May 14, 2001Date of Patent: August 5, 2003Assignee: Incyte CorporationInventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler
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Patent number: 6553317Abstract: The present invention provides relational database systems for storing biomolecular sequence information together with biological annotations detailing the source of the sequence information, and associated reagent information. The acquisition, storage and access of reagent information associated with databased biomolecular sequence information is a particular advantage of the present invention. Such reagent information identifies genetic information and materials which may be made available to a user of the relational database system of the present invention for further application in research, therapeutic pharmaceutical development or other fields. The reagent information aspect of the present invention is preferably used in conjunction with a biomolecular sequence relational database system.Type: GrantFiled: March 4, 1998Date of Patent: April 22, 2003Assignee: Incyte Pharmaceuticals, Inc.Inventors: Stephen E. Lincoln, Tod M. Klingler, Landes C. Wong, Scott R. Panzer, David M. Hodgson, Laura Y. Ito, Andrew D. Ament, Richard Cathcart, Helen E. Jolley, Ingrid E. Akerblom, Brian M. McKelligon, Mayank K. Thanawala
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Publication number: 20030009296Abstract: Disclosed is a relational database system for storing and manipulating biomolecular sequence information, the database including genomic libraries for a plurality of types of organisms, the libraries having multiple genomic sequences, at least some of which represent open reading frames located along a contiguous sequence on each the plurality of organisms' genomes, and a user interface capable of receiving a selection of two or more of the genomic libraries for comparison and displaying the results of the comparison. The system also provides a user interface capable of receiving a selection of one or more probe open reading frames for use in determining homologous matches between such probe open reading frame(s) and the open reading frames in the genomic libraries, and displaying the results of the determination.Type: ApplicationFiled: March 15, 2002Publication date: January 9, 2003Applicant: Incyte Genomics, Inc.Inventors: Cathryn E. Sabatini, Joe Don Heath, Peter A. Covitz, Tod M. Klingler, Frank D. Russo, Stephanie F. Berry
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Publication number: 20020077309Abstract: The invention provides compositions and novel polynucleotides and their encoded proteins that co-express with genes involved in insulin synthesis and known to be associated with pancreatic disorders. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of pancreatic disorders.Type: ApplicationFiled: May 23, 2001Publication date: June 20, 2002Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler
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Publication number: 20020077470Abstract: The invention provides compositions and novel polynucleotides and their encoded proteins that serve as surrogate markers in that they co-express with genes known to be involved associated with disorders associated with cardiac muscle function. The invention also provides expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, evaluation of therapies and treatment of disorders associated with cardiac muscle function.Type: ApplicationFiled: June 12, 2001Publication date: June 20, 2002Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler, Yalda Azimzai
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Publication number: 20020064792Abstract: The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.Type: ApplicationFiled: September 19, 2001Publication date: May 30, 2002Inventors: Stephen E. Lincoln, Tod M. Klingler, Janice Au-Young, Y. Tom Tang, Richard D. Goold, Ingrid E. Akerblom, Jeffrey J. Seilhamer, Phillip R. Hawkins, Lynn E. Murry, Angelo M. Delegeane, Wendy B. Levine, Jennifer L. Hillman, Surya K. Goli, Christina M. Altus, Olga Bandman, Samuel T. LaBrie, Purvi Shah
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Patent number: 6389428Abstract: A computer system stores biomolecular data in a database in a memory. The biomolecular database has a set of entities. Each entity stores attributes for a plurality of entries. At least one attribute is stored in an array. Data associated with an entry is stored at a location in the array. An entity offset designates the location of the data in the array. The same entity offset value is used to access data associated with a particular entry for all attributes within the entity.Type: GrantFiled: April 11, 2001Date of Patent: May 14, 2002Assignee: Incyte Pharmaceuticals, Inc.Inventors: Philippe E. Rigault, Anne L. Curtis, Richard D. Goold, David A. Hadley, Harold H. Hibbert, Tod M. Klingler, Robert E. Lagace, Laura L. Stuve, Michael G. Walker, Michael P. Wood
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Publication number: 20020042680Abstract: A computer system stores biomolecular data in a database in a memory. The biomolecular database has a set of entities. Each entity stores attributes for a plurality of entries. At least one attribute is stored in an array. Data associated with an entry is stored at a location in the array. An entity offset designates the location of the data in the array. The same entity offset value is used to access data associated with a particular entry for all attributes within the entity.Type: ApplicationFiled: April 11, 2001Publication date: April 11, 2002Inventors: Philippe E. Rigault, Anne L. Curtis, Richard D. Goold, David A. Hadley, Harold H. Hibbert, Tod M. Klingler, Robert E. Lagace, Laura L. Stuve, Michael G. Walker, Michael P. Wood
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Publication number: 20020019000Abstract: The invention provides compositions, polynucleotides and proteins that coexpress with known matrix-remodeling genes. The invention also provides expression vectors and host cells, and ligands and antibodies which specifically bind the proteins. The invention also relates to the use of these biomolecules in diagnosis, prognosis, prevention, treatment, and evaluation of therapies for diseases associated with matrix-remodeling.Type: ApplicationFiled: March 26, 2001Publication date: February 14, 2002Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler
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Patent number: 6303297Abstract: The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.Type: GrantFiled: November 13, 1997Date of Patent: October 16, 2001Assignee: Incyte Pharmaceuticals, Inc.Inventors: Steve E. Lincoln, Tod M. Klingler, Janice Au-Young, Y. Tom Tang, Richard D. Goold, Ingrid E. Akerblom, Jeffrey J. Seilhamer, Phillip R. Hawkins, Lynn E. Murry, Angelo M. Delegeane, Wendy B. Levine, Jennifer L. Hillman, Surya K. Goli, Christina M. Altus, Olga Bandman, Samuel T. LaBrie, Purvi Shah
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Patent number: 6277574Abstract: The invention provides novel kidney disease-associated genes and polypeptides encoded by those genes. The invention also provides expression vectors, host cells, and antibodies. The invention also provides methods for diagnosing, treating or preventing diseases of the kidney.Type: GrantFiled: April 9, 1999Date of Patent: August 21, 2001Assignee: Incyte Genomics, Inc.Inventors: Michael G. Walker, Wayne Volkmuth, Tod M. Klingler, Yalda Azimzai, Henry Yue