Patents by Inventor Tod Woolf

Tod Woolf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Double-stranded oligonucleotides
    Publication number: 20060009409
    Abstract: Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions.
    Type: Application
    Filed: February 2, 2005
    Publication date: January 12, 2006
    Inventor: Tod Woolf
  • Three component chimeric antisense oligonucleotides
    Publication number: 20050202541
    Abstract: This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: an RNase H activating region, a complementary region and 3? and 5? ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
    Type: Application
    Filed: January 14, 2005
    Publication date: September 15, 2005
    Inventors: Amy Arrow, Roderic Dale, Tod Woolf
  • Chemically modified double stranded nucleic acid molecules
    Publication number: 20050176018
    Abstract: This invention relates to novel chemically-modified nucleic acid molecules having specified formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.
    Type: Application
    Filed: November 17, 2003
    Publication date: August 11, 2005
    Applicant: Sirna Therapeutics, Inc.
    Inventors: James Thompson, Leonid Beigelman, James McSwiggen, Alexander Karpeisky, Laurent Bellon, Mark Reynolds, Michael Zwick, Thale Jarvis, Tod Woolf, Peter Haeberli, Jasenka Matulic-Adamic
  • Antisense oligomers
    Publication number: 20040224913
    Abstract: Antisense oligomers which possess improved properties over those taught in the prior art are disclosed. The instant methods enable the enhanced uptake of oligomers, increased affinity of the oligomers for their target molecules, increased resistance of oligomers to nucleases, decreased toxicity. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions.
    Type: Application
    Filed: July 21, 2003
    Publication date: November 11, 2004
    Applicant: Sequitur, Inc.
    Inventor: Tod Woolf
  • Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
    Patent number: 6673611
    Abstract: This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: January 6, 2004
    Assignee: Sirna Therapeutics, Inc.
    Inventors: James Thompson, Leonid Beigelman, James McSwiggen, Alexander Karpeisky, Laurent Bellon, Mark Reynolds, Michael Zwick, Thale Jarvis, Tod Woolf, Peter Haeberli, Jasenka Matulic-Adamic
  • Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
    Publication number: 20020142980
    Abstract: The invention features nucleic acid molecules with novel combinations of chemical modifications which are able to modulate gene expression.
    Type: Application
    Filed: May 25, 2001
    Publication date: October 3, 2002
    Inventors: James Thompson, Leonid Beigelman, James McSwiggen, Alexander Karpeisky, Laurent Bellon, Mark Reynolds, Michael Zwick, Thale Jarvis, Tod Woolf, Peter Haeberli, Jasenka Matulic-Adamic
  • Respiratory syncytial virus ribozymes
    Patent number: 5693532
    Abstract: An enzymatic RNA molecule which cleaves respiratory syncytial virus (RSV) genomic and RSV encoded RNA.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: December 2, 1997
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: James McSwiggen, Kenneth Draper, Pam Pavco, Tod Woolf