Patents by Inventor Todd Blythe

Todd Blythe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymorphic forms of (S)-1-tetrahydrofuran-3-yl-3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate
    Patent number: 8153668
    Abstract: The present invention relates to polymorphic forms of (S)-tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate, processes therein, pharmaceutical compositions thereof, and uses therewith.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: April 10, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Todd Blythe, Alex Eberlin, Michael Hurrey, David Jonaitis, Philip Nyce, Stephan Parent, John Snoonian
  • Polymorphic forms of (S)-1-cyanobutan-2-yl (S)-1-(3-3-(3-methoxy-4-(oxazol-5-yl)phenyl)uriedo)phenyl)ethylcarbamate
    Patent number: 7829723
    Abstract: The present invention relates to polymorphic forms of (S)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate, pharmaceutical compositions thereof, processes to prepare therein, and uses therewith.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: November 9, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Todd Blythe, Petinka Vlahova
  • Processes for preparing biaryl ureas and analogs thereof
    Patent number: 7777048
    Abstract: The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: August 17, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Graham Ansell, Todd Blythe, Andrew Jones, Benjamin Littler, Adam Looker, Philip Nyce, John Snoonian
  • Polymorphic forms of (1-{3-[3-(4-cyano-3-methoxy-phenyl) ureido]-phenyl}-ethyl)-carbamic acid-2-cyano-1-ethyl-ethyl ester
    Patent number: 7659309
    Abstract: The present invention relates to polymorphic forms of (1-{3-[3-(4-cyano-3-methoxy-phenyl)ureido]-phenyl}-ethyl)-carbamic acid-2-cyano-1-ethyl-ethyl ester, processes therein, pharmaceutical compositions thereof, and uses therewith.
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: February 9, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Todd Blythe, Philip Nyce, Yong Cui
  • POLYMORPHIC FORMS OF (S)-1-TETRAHYDROFURAN-3-YL-3-(3-(3-METHOXY-4-(OXAZOL-5-YL)PHENYL)UREIDO)BENZYL CARBAMATE
    Publication number: 20090324545
    Abstract: The present invention relates to polymorphic forms of (S)-tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate, processes therein, pharmaceutical compositions thereof, and uses therewith.
    Type: Application
    Filed: September 8, 2009
    Publication date: December 31, 2009
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Todd Blythe, Alex Eberlin, Michael Hurrey, David Jonaitis, Philip Nyce, Stephan Parent, John Snoonian
  • Polymorphic forms of (S).-tetrahydrofuran-3-yl-3-(3-(3-methoxy-4-(oxazol-5-yl) phenyl) ureido) benzylcarbamate
    Patent number: 7605270
    Abstract: The present invention relates to polymorphic forms of (S)-tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate (Compound 1): and pharmaceutical compositions thereof. The present invention also relates to processes to prepare compound 1 and pharmaceutical compositions thereof. Compound 1 is an IMPDH inhibitor useful in treating IMPDH-mediated diseases such as immune system related diseases, viral diseases, and cancers.
    Type: Grant
    Filed: May 8, 2006
    Date of Patent: October 20, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Todd Blythe, Alex Eberlin, Michael Hurrey, David Jonaitis, Philip Nyce, Stephan Parent, John Snoonian
  • PROCESSES FOR PREPARING BIARYL UREAS AND ANALOGS THEREOF
    Publication number: 20090221835
    Abstract: The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.
    Type: Application
    Filed: May 5, 2009
    Publication date: September 3, 2009
    Inventors: Graham Ansell, Todd Blythe, Andrew Jones, Benjamin Littler, Adam Looker, Philip Nyce, John Snoonian
  • POLYMORPHIC FORMS OF (S)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)uriedo)phenyl)ethylcarbamate
    Publication number: 20090170915
    Abstract: The present invention relates to polymorphic forms of (S)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate, pharmaceutical compositions thereof, processes to prepare therein, and uses therewith.
    Type: Application
    Filed: February 4, 2009
    Publication date: July 2, 2009
    Inventors: Todd Blythe, Petinka Vlahova
  • Processes for preparing biaryl ureas and analogs thereof
    Patent number: 7544810
    Abstract: The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.
    Type: Grant
    Filed: May 9, 2006
    Date of Patent: June 9, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Graham Ansell, Todd Blythe, Andrew Jones, Benjamin Littler, Adam Looker, Philip Nyce, John Snoonian
  • Polymorphic forms of (S)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4- (oxazol-5-yl)phenyl) ureido)phenyl) ethylcarbamate
    Patent number: 7504515
    Abstract: The present invention relates to polymorphic forms of (S)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate (Compound 1): pharmaceutical compositions thereof. The present invention also relates to processes to prepare compound 1 and pharmaceutical compositions thereof. Compound 1 is an IMPDH inhibitor useful in treating IMPDH-mediated diseases such as immune system related diseases, viral diseases, and cancers.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: March 17, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Todd Blythe, Petinka Vlahova
  • Processes for preparing biaryl ureas and analogs thereof
    Publication number: 20080021222
    Abstract: The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.
    Type: Application
    Filed: May 9, 2006
    Publication date: January 24, 2008
    Inventors: Graham Ansell, Todd Blythe, Andrew Jones, Benjamin Littler, Adam Looker, Philip Nyce, John Snoonian
  • Polymorphic forms of (S). -tetrahydrofuran-3-yl-3- (3- (3-methoxy-4- (oxazol-5-yl) pheny1) ureido) benzylcarbamate
    Publication number: 20070281980
    Abstract: The present invention relates to polymorphic forms of (S)-tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate, processes therein, pharmaceutical compositions thereof, and uses therewith.
    Type: Application
    Filed: May 8, 2006
    Publication date: December 6, 2007
    Inventors: Todd Blythe, Alex Eberlin, Michael Hurrey, David Jonaitis, Philip Nyce, Stephan Parent, John Snoonian
  • Polymorphic forms of (S)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4- (oxazol-5-yl)phenyl) ureido)phenyl) ethylcarbamate
    Publication number: 20070099972
    Abstract: The present invention relates to polymorphic forms of (S)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate, pharmaceutical compositions thereof, processes to prepare therein, and uses therewith.
    Type: Application
    Filed: May 25, 2006
    Publication date: May 3, 2007
    Inventors: Todd Blythe, Petinka Vlahova
  • Processes for producing 4-aminoquinazolines
    Publication number: 20060166963
    Abstract: The present invention relates to methods for preparing compounds of formula I: or suitable salts thereof useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also relates to methods for preparing intermediates related thereto.
    Type: Application
    Filed: December 15, 2005
    Publication date: July 27, 2006
    Inventors: Richard Silva, Andrew Jones, Todd Blythe
  • Polymorphic forms of (1-{3-[3-(4-cyano-3-methoxy-phenyl) ureido]-phenyl}-ethyl)-carbamic acid-2-cyano-1-ethyl-ethyl ester
    Publication number: 20050239879
    Abstract: The present invention relates to polymorphic forms of (1-{3-[3-(4-cyano-3-methoxy-phenyl)ureido]-phenyl}-ethyl)-carbamic acid-2-cyano-1-ethyl-ethyl ester, processes therein, pharmaceutical compositions thereof, and uses therewith.
    Type: Application
    Filed: March 22, 2005
    Publication date: October 27, 2005
    Inventors: Todd Blythe, Philip Nyce, Yong Cui
  • Enzymatic resolution of .alpha.-tertiary carboxylic acid esters
    Patent number: 5492830
    Abstract: A method for the resolution of .alpha.-tertiary carboxylic acid esters by partial hydrolysis is disclosed. The partial hydrolysis is carried out by contacting the esters with an aqueous solution in the presence of a serine carboxypeptidase, and the hydrolysis product is separated from unreacted starting material to obtain the hydrolysis product or the unreacted starting material in enantiomerically enriched form. A novel ester hydrolase which is particularly useful in this method, and a nucleotide sequence encoding this enzyme, are also described.
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: February 20, 1996
    Assignee: Genzyme Corporation
    Inventors: Helmut Kalwass, Christopher Yee, Todd Blythe, Spencer Shames, Elizabeth Rogers
  • Resolution of .alpha.-tertiary carboxylic acid esters using lipase from Candida lipolytica
    Patent number: 5202260
    Abstract: A method for the resolution of .alpha.-tertiary carboxylic acid esters by partial hydrolysis is disclosed. The partial hydrolysis is carried out by contacting the esters with an aqueous solution in the presence of a lipase derived from Candida lipolytica, and the hydrolysis product is separated from unreacted starting material to obtain the hydrolysis product or the unreacted starting material in enantiomerically enriched form.
    Type: Grant
    Filed: May 8, 1991
    Date of Patent: April 13, 1993
    Assignee: Genzyme Corporation
    Inventors: Christopher Yee, Todd A. Blythe, Alan E. Walts