Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: A system for releasably securing a drawer to a drawer slide includes a drawer slide, a catch insert for receiving and securing a portion of a locking lever, a drawer, a locking lever comprising at least one tooth, pivotably mounted to the drawer and a spring for releasably engaging the at least one tooth in contact with the catch insert. The catch insert can be mounted in the aperture provided in the drawer slide and can include a plurality of ridges and grooves aligned in a direction parallel to the sliding direction of the drawer, and can extend in a direction perpendicular to the sliding direction of the drawer. The locking lever can include a plurality of teeth, which are aligned in a direction parallel to the sliding direction of the drawer, and can extend in a direction perpendicular to the sliding direction of the drawer.

Abstract: A roller and stopper mechanism for drawer slide systems which overcomes the disadvantages of the prior art and effectively provides a low friction rolling surface between two drawer slides in directions parallel to and perpendicular to the length of the drawer slide, and provides a stopper to provide shock absorbing means to the system. The roller and stopper mechanism includes a body portion with two opposing ends and two opposing sides, and having a roller associated therewith, a first leg portion extending substantially perpendicular from one end of the body portion, and having a roller associated therewith, and a second leg portion extending substantially perpendicular from the opposite end of the body portion, and having a roller associated therewith.

Abstract: A drawer closing mechanism includes a toothed rack fixed in position with respect to a furniture frame member, a toothed drive gear mounted to a drawer for engaging the teeth on the rack, and a spring with two ends, one end being fixedly attached to the drive gear and rotatable therewith and the opposite end being fixed, wherein as the drawer is pulled open, the teeth on the drive gear engage the teeth on the rack and rotate the drive gear, and as the drive gear rotates, the spring is wound and potential energy is stored in the tension therein. The spring can be a flat wire spring wound circumferentially about a central point in a spiral.

Abstract: This invention relates to a hinge assembly comprising a frame plate for engagement to a furniture frame member comprising means for engaging a spring assembly, an intermediate plate comprising means for rotatably engaging the intermediate plate with a pin, and two side members, a spring assembly for releasably engaging the intermediate plate to the frame plate, and, a base plate comprising two side members each having at least one aperture therein, and a pin. The pin extends through the apertures on the side members of the base plate and the means for rotatably engaging the intermediate plate with a pin provide a slideable engagement between the base plate and the intermediate plate, and the spring assembly provides a releasable engagement between the frame plate and the intermediate plate.

Abstract: A shock absorber mounting system for a drawer slide system comprising a fixed drawer slide member fixedly attached to a furniture frame, a moveable drawer slide fixedly attached to a drawer and slideably attached to the fixed slide member for guiding the drawer in and out of a furniture frame, a shock absorber comprising a cylinder and a piston wherein the piston is operable to slide in and out of the cylinder and wherein air is controllably allowed to enter or escape the cylinder in response to movement of the piston, a retainer clip comprising a central aperture for receiving and retaining the shock absorber and a base portion comprising means for engaging a mounting bracket, and a mounting bracket comprising means for retaining the retainer clip and shock absorber and wherein the mounting bracket is fixedly attached to the fixed drawer slide.

Abstract: A drawer closing mechanism comprising a rack fixed in position with respect to a furniture frame member and comprising a plurality of teeth a drive gear mounted to a drawer and comprising a plurality of teeth for engaging the teeth on the rack, and a spring with two ends, one end fixedly attached to said drive gear and rotatable therewith and the opposite end fixed, wherein as the drawer is pulled open, the teeth on the drive gear engage the teeth on the rack and rotate the drive gear, and as the drive gear rotates, the spring is wound and potential energy is stored in the tension therein. The drawer slide is mounted to the furniture frame member, and the rack is mounted to the drawer slide. In a preferred embodiment of the present invention, the spring comprises a flat wire spring wound circumferentially about a central point in a spiral.

Abstract: A front locking device for releasably securing a drawer to a drawer slide comprising a drawer slide comprising catch means for receiving and securing a portion of a locking lever, a drawer, a locking lever comprising at least one tooth, pivotably mounted to the drawer and spring means for releasably engaging the at least one tooth in contact with the catch means. The catch means comprises a catch insert mounted in an aperture provided in the drawer slide comprising a plurality of ridges and grooves aligned in a direction parallel to the sliding direction of the drawer, and extend in a direction perpendicular to the sliding direction of the drawer. The locking lever comprises a plurality of teeth, which are aligned in a direction parallel to the sliding direction of the drawer, and extending in a direction perpendicular to the sliding direction of the drawer.

Abstract: A roller and stopper mechanism for drawer slide systems which overcomes the disadvantages of the prior art and effectively provides a low friction rolling surface between two drawer slides in directions parallel to and perpendicular to the length of the drawer slide, and provides a stopper to provide shock absorbing means to the system. The roller and stopper mechanism comprising a body portion comprising two opposing ends and two opposing sides, and having a roller associated therewith, a first leg portion extending substantially perpendicular from one end of the body portion, and having a roller associated therewith, and a second leg portion extending substantially perpendicular from the opposite end of the body portion, and having a roller associated therewith.

Abstract: A shock absorber mounting system for a drawer slide system comprising a fixed drawer slide member fixedly attached to a furniture frame, a moveable drawer slide fixedly attached to a drawer and slideably attached to the fixed slide member for guiding the drawer in and out of a furniture frame, a shock absorber comprising a cylinder and a piston wherein the piston is operable to slide in and out of the cylinder and wherein air is controllably allowed to enter or escape the cylinder in response to movement of the piston, a retainer clip comprising a central aperture for receiving and retaining the shock absorber and a base portion comprising means for engaging a mounting bracket, and a mounting bracket comprising means for retaining the retainer clip and shock absorber and wherein the mounting bracket is fixedly attached to the fixed drawer slide.

Abstract: This invention relates to a hinge assembly comprising a frame plate for engagement to a furniture frame member comprising means for engaging a spring assembly, an intermediate plate comprising means for rotatably engaging the intermediate plate with a pin, and two side members, a spring assembly for releasably engaging the intermediate plate to the frame plate, and, a base plate comprising two side members each having at least one aperture therein, and a pin. The pin extends through the apertures on the side members of the base plate and the means for rotatably engaging the intermediate plate with a pin provide a slideable engagement between the base plate and the intermediate plate, and the spring assembly provides a releasable engagement between the frame plate and the intermediate plate.

Abstract: This invention relates to hinges for mounting a door on a furniture article frame. The hinges include at least a hinge cup member adapted to be affixed to the furniture door, a top hinge arm segment pivotably connected to the hinge cup member and comprising a top elongated aperture and two tabs, and an L-shaped hinge arm segment comprising at least a circular aperture, a center hole and two grooves. A base hinge arm segment comprising an elongated center hole, a circular aperture and an upper flange may also be used with the top hinge arm segment and the L-shaped hinge arm segment to allow adjustments to be made in a third direction. In some embodiments, turning a cam or eccentric screw allows adjustments to be made horizontally from side-to-side so that the desired spacing of the door from opposite sides of the door opening can be set.

Abstract: This invention relates to hinges for mounting a door on a furniture article frame. The hinges include at least a hinge cup member adapted to be affixed to the furniture door, a top hinge arm segment pivotably connected to the hinge cup member and comprising a top elongated aperture and two tabs, and an L-shaped hinge arm segment comprising at least a circular aperture, a center hole and two grooves. A base hinge arm segment comprising an elongated center hole, a circular aperture and an upper flange may also be used with the top hinge arm segment and the L-shaped hinge arm segment to allow adjustments to be made in a third direction. In some embodiments, turning a cam or eccentric screw allows adjustments to be made horizontally from side-to-side so that the desired spacing of the door from opposite sides of the door opening can be set.