Patents by Inventor Todd C. Henninger

Todd C. Henninger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-O-acyl ketolide antibacterials
    Patent number: 6825170
    Abstract: 6-O-Acyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, W, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: November 30, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Todd C. Henninger, Mark J. Macielag, Manomi A. Tennakoon, Xiaodong Xu
  • 3-descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents
    Patent number: 6825172
    Abstract: 3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents of the formula: wherein R1, W, R3, R4, R5, R6, X, X′, and Z are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: November 30, 2004
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Todd C. Henninger, Mark J. Macielag, Brett A. Marinelli, Bin Zhu
  • 6-O-carbamate-11,12-lacto-ketolide antimicrobials
    Patent number: 6713455
    Abstract: 6-O-Carbamate-11,12-lacto-ketolide antimicrobials of the formula: wherein R1, R2, R3 R7, and R8 are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: September 16, 2002
    Date of Patent: March 30, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Eugene B. Grant, III, Todd C. Henninger, Mark J. Macielag, Deodialsingh Guiadeen
  • 3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents
    Publication number: 20040018994
    Abstract: 3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents of the formula: 1
    Type: Application
    Filed: May 28, 2003
    Publication date: January 29, 2004
    Inventors: Todd C. Henninger, Mark J. Macielag, Brett A. Marinelli, Bin Zhu
  • 6-O-acyl ketolide antibacterials
    Publication number: 20030220272
    Abstract: 6-O-Acyl ketolide antibacterials of the formula: 1
    Type: Application
    Filed: November 21, 2002
    Publication date: November 27, 2003
    Inventors: Todd C. Henninger, Mark J. Macielag, Manomi A. Tennakoon, Xiaodong Xu
  • Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8
    Publication number: 20030216386
    Abstract: The invention relates to isoxazole and oxadiazole compounds of Formulae I and II, 1
    Type: Application
    Filed: April 10, 2003
    Publication date: November 20, 2003
    Inventors: Michele A. Weidner-Wells, Todd C. Henninger, Dennis J. Hlasta
  • 6-O-carbamoyl ketolide antibacterials
    Patent number: 6613747
    Abstract: 6-O-Carbamoyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, R5, R6, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: September 2, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Todd C. Henninger, Xiaodong Xu
  • Ketolide antibacterials
    Patent number: 6590083
    Abstract: The present invention includes compounds of the formula wherein: X is hydrogen or halide; R2 is hydrogen, acyl, or a hydroxy protecting group; R6 is hydrogen, hydroxyl, or —ORa wherein Ra is a substituted or unsubstituted moiety selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heterocyclo, aryl(C1-C10)alkyl, aryl(C2-C10)alkenyl, aryl(C2-C10)alkynyl, heterocyclo(C1-C10)alkyl, heterocyclo(C2-C10)alkenyl, and heterocyclo(C2-C10)alkynyl; R13 is hydrogen or a substituted or unsubstituted moiety wherein the moiety is selected from the group consisting of methyl; C3-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heterocyclo, aryl(C1-C10)alkyl, aryl(C2-C10)alkenyl, aryl(C2-C10)alkynyl, heterocyclo(C1-C10)alkyl, heterocyclo(C2-C10)alkenyl, and heterocyclo(C2-C10)alkynyl; and, R is hydrogen or a substituted or unsubstituted moiety wherein the moiety is selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heteroc
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: July 8, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Dennis Hlasta, Todd C. Henninger, Eugene B. Grant, Chaitin Khosla, Daniel T. W. Chu, Gary Ashley
  • 6-O-carbamate-11,12-lacto-ketolide antimicrobials
    Publication number: 20030125267
    Abstract: 6-O-Carbamate-11,12-lacto-ketolide antimicrobials of the formula: 1
    Type: Application
    Filed: September 16, 2002
    Publication date: July 3, 2003
    Inventors: Eugene B. Grant, Todd C. Henninger, Mark J. Macielag, Deodialsingh Guiadeen
  • Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8
    Patent number: 6579880
    Abstract: The invention relates to isoxazole and oxadiazole compounds of Formulae I and II, pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the action of IL-8 and are thus useful as anti-inflammatory agents for a variety of diseases.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: June 17, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michele A. Weidner-Wells, Todd C. Henninger, Dennis J. Hlasta
  • 6-O-CARBAMOYL KETOLIDE ANTIBACTERIALS
    Publication number: 20030013663
    Abstract: 6-O-Carbamoyl ketolide antibacterials of the formula: 1
    Type: Application
    Filed: February 1, 2001
    Publication date: January 16, 2003
    Inventors: Todd C. Henninger, Xiaodong Xu
  • 6-O-Carbamoyl ketolide antibacterials
    Patent number: 6472372
    Abstract: 6-O-Carbamoyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, R5, R6, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: October 29, 2002
    Assignee: Ortho-McNeil Pharmaceuticals, Inc.
    Inventors: Todd C. Henninger, Xiaodong Xu
  • Ketolide antibacterials
    Patent number: 6458771
    Abstract: A series of ketolide antibacterials in the macrolide family of the formula: intermediates used in their manufacture and pharmaceutical compositions containing them. The compounds are erythromycin analogues useful in the treatment of bacterial and protozoal infections and in the treatment of other conditions involving gastric motility.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: October 1, 2002
    Assignees: Ortho-McNeil Pharmaceutical, Inc., Kosan Biosciences, Inc.
    Inventors: Dennis J. Hlasta, Todd C. Henninger, Eugene B. Grant, Chaitin Khosla, Daniel T. W. Chu
  • 6-0-carbamoyl ketolide antibacterials
    Publication number: 20020115620
    Abstract: 6-O-Carbamoyl ketolide antibacterials of the formula: 1
    Type: Application
    Filed: December 5, 2001
    Publication date: August 22, 2002
    Inventors: Todd C. Henninger, Xiaodong Xu
  • Ketolide antibacterials
    Patent number: 6399582
    Abstract: A series of ketolide antibacterials in the macrolide family of the formula: intermediates used in their manufacture and pharmaceutical compositions containing them. The compounds are erythromycin analogues useful in the treatment of bacterial and protozoal infections and in the treatment of other conditions involving gastric motility.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: June 4, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Dennis J. Hlasta, Todd C. Henninger, Eugene B. Grant, Chaitin Khosla, Daniel T. W. Chu
  • Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8
    Publication number: 20020049213
    Abstract: The invention relates to isoxazole and oxadiazole compounds of Formulae I and II, 1
    Type: Application
    Filed: June 6, 2001
    Publication date: April 25, 2002
    Inventors: Michele A. Weidner-Wells, Todd C. Henninger, Dennis J. Hlasta