Patents by Inventor Todd C. Holmes

Todd C. Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of reducing neuronal electrical activity with a potassium channel subunit
    Patent number: 7192773
    Abstract: Methods of reducing the excitability of an excitable cell by transforming an excitable cell with a nucleic acid construct encoding an open rectifier K+ channel (dORK) (SEQ ID NO:2) or a modified open rectifier K+ channel (dORK?) (SEQ ID NO:4), and expressing the open rectifier K+ channel in the excitable cell, wherein the excitability of the transformed cell is reduced. Also featured are transgenic animals expressing dORK or dORK?.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: March 20, 2007
    Assignee: New York University
    Inventors: Michael N. Nitabach, Justin Blau, Todd C. Holmes, Steven A. N. Goldstein
  • Method of reducing neuronal electrical activity with a potassium channel subunit
    Publication number: 20030237102
    Abstract: Methods of reducing the excitability of an excitable cell by transforming an excitable cell with a nucleic acid construct encoding an open rectifier K+ channel (dORK) (SEQ ID NO:2) or a modified open rectifier K+ channel (dORK&Dgr;) (SEQ ID NO:4), and expressing the open rectifier K+ channel in the excitable cell, wherein the excitability of the transformed cell is reduced. Also featured are transgenic animals expressing dORK or dORK&Dgr;.
    Type: Application
    Filed: May 15, 2003
    Publication date: December 25, 2003
    Inventors: Michael N. Nitabach, Justin Blau, Todd C. Holmes, Steven A. N. Goldstein
  • Method for assessing modulation of potassium ion channel activity
    Patent number: 5955259
    Abstract: The present invention relates to a method for assessing the ability of a compound to modulate the formation of a complex between a potassium channel and a protein tyrosine kinase. The method comprises the steps of (1) contacting a first polypeptide comprising the proline-rich binding region of the potassium channel, a second protein comprising the SH3 binding domain of the protein tyrosine kinase and the compound to be assessed; and (2) measuring the extent of complex formation between the first polypeptide and the second polypeptide.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: September 21, 1999
    Assignee: Brandeis University
    Inventors: Todd C. Holmes, Irwin B. Levitan