Patents by Inventor Todd C. Strother
Todd C. Strother has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9952138Abstract: The present invention is thus directed to an automated system and method of varying the optical path length in a sample that a light from a spectrophotometer must travel through. Such arrangements allow a user to easily vary the optical path length while also providing the user with an easy way to clean and prepare a transmission cell for optical interrogation. Such path length control can be automatically controlled by a programmable control system to quickly collect and stores data from different path lengths as needed for different spectrographic analysis. Such a methodology and system, as presented herein, is able to return best-match spectra with far fewer computational steps and greater speed than if all possible combinations of reference spectra are considered.Type: GrantFiled: October 9, 2015Date of Patent: April 24, 2018Assignee: Thermo Electron Scientific Instruments LLCInventors: John Magie Coffin, Damian W. Ashmead, Todd C. Strother
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Publication number: 20160033390Abstract: The present invention is thus directed to an automated system and method of varying the optical path length in a sample that a light from a spectrophotometer must travel through. Such arrangements allow a user to easily vary the optical path length while also providing the user with an easy way to clean and prepare a transmission cell for optical interrogation. Such path length control can be automatically controlled by a programmable control system to quickly collect and stores data from different path lengths as needed for different spectrographic analysis. Such a methodology and system, as presented herein, is able to return best-match spectra with far fewer computational steps and greater speed than if all possible combinations of reference spectra are considered.Type: ApplicationFiled: October 9, 2015Publication date: February 4, 2016Inventors: John Magie COFFIN, Damian W. ASHMEAD, Todd C. STROTHER
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Patent number: 9170191Abstract: The present invention is thus directed to an automated system and method of varying the optical path length in a sample that a light from a spectrophotometer must travel through. Such arrangements allow a user to easily vary the optical path length while also providing the user with an easy way to clean and prepare a transmission cell for optical interrogation. Such path length control can be automatically controlled by a programmable control system to quickly collect and stores data from different path lengths as needed for different spectrographic analysis. Such a methodology and system, as presented herein, is able to return best-match spectra with far fewer computational steps and greater speed than if all possible combinations of reference spectra are considered.Type: GrantFiled: June 28, 2013Date of Patent: October 27, 2015Assignee: Thermo Electron Scientific Instruments LLCInventors: John Magie Coffin, Damian W. Ashmead, Todd C. Strother
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Publication number: 20140008539Abstract: The present invention is thus directed to an automated system and method of varying the optical path length in a sample that a light from a spectrophotometer must travel through. Such arrangements allow a user to easily vary the optical path length while also providing the user with an easy way to clean and prepare a transmission cell for optical interrogation. Such path length control can be automatically controlled by a programmable control system to quickly collect and stores data from different path lengths as needed for different spectrographic analysis. Such a methodology and system, as presented herein, is able to return best-match spectra with far fewer computational steps and greater speed than if all possible combinations of reference spectra are considered.Type: ApplicationFiled: June 28, 2013Publication date: January 9, 2014Inventors: John Magie COFFIN, Damian W. ASHMEAD, Todd C. STROTHER
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Patent number: 7582422Abstract: Chemically-modified surfaces on unoxidized carbon, silicon, and germanium substrates are disclosed. Ultraviolet radiation mediates the reaction of protected ?-modified, ?-unsaturated aminoalkenes (preferred) with hydrogen-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.Type: GrantFiled: October 11, 2002Date of Patent: September 1, 2009Assignee: Wisconsin Alumni Research FoundationInventors: Todd C. Strother, Lloyd M. Smith, Robert J. Hamers
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Patent number: 6878523Abstract: The present invention relates to novel methods for the analysis of molecular interactions. In particular, the present invention relates to compositions and methods for molecular interaction assays performed in solution and on solid surfaces. The present invention thus provides improves methods and compositions for the analysis of molecular interactions.Type: GrantFiled: May 8, 2002Date of Patent: April 12, 2005Assignee: Gentel Bio Surfaces, Inc.Inventors: Bryce P. Nelson, Todd C. Strother
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Patent number: 6689858Abstract: Chemically-modified surfaces on unoxidized, bromine- or iodine-terminated carbon, silicon, and germanium substrates are disclosed. Visible light mediates the reaction of protected &ohgr;-modified, &agr;-unsaturated aminoalkenes (preferred) with bromine- or iodine-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface. These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.Type: GrantFiled: January 26, 2001Date of Patent: February 10, 2004Assignee: Wisconsin Alumni Research FoundationInventors: Robert J. Hamers, Wei Cai, Lloyd M. Smith, Todd C. Strother
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Publication number: 20040009516Abstract: The present invention relates to novel components for surface plasmon resonance (SPR) detection of molecular interactions. In particular, the present invention relates to disposable arrayed prisms for use in SPR. The present invention provides improved prisms comprising target biological macromolecules for use in SPR.Type: ApplicationFiled: May 8, 2003Publication date: January 15, 2004Inventors: Bryce P. Nelson, Todd C. Strother
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Publication number: 20030211480Abstract: The present invention relates to novel methods for the analysis of molecular interactions. In particular, the present invention relates to compositions and methods for molecular interaction assays performed in solution and on solid surfaces. The present invention thus provides improves methods and compositions for the analysis of molecular interactions.Type: ApplicationFiled: May 8, 2002Publication date: November 13, 2003Inventors: Bryce P. Nelson, Todd C. Strother
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Publication number: 20030125496Abstract: Chemically-modified surfaces on unoxidized carbon, silicon, and germanium substrates are disclosed. Ultraviolet radiation mediates the reaction of protected &ohgr;-modified, &agr;-unsaturated aminoalkenes (preferred) with hydrogen-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.Type: ApplicationFiled: October 11, 2002Publication date: July 3, 2003Inventors: Todd C. Strother, Lloyd M. Smith, Robert J. Hamers
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Patent number: 6569979Abstract: Chemically-modified surfaces on unoxidized carbon, silicon, and germanium substrates are disclosed. Ultraviolet radiation mediates the reaction of protected &ohgr;-modified, &agr;-unsaturated aminoalkenes (preferred) with hydrogen-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface. These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.Type: GrantFiled: September 8, 2000Date of Patent: May 27, 2003Assignee: Wisconsin Alumni Research FoundationInventors: Todd C. Strother, Lloyd M. Smith, Robert J. Hamers
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Publication number: 20020137195Abstract: Chemically-modified surfaces on unoxidized, bromine- or iodine-terminated carbon, silicon, and germanium substrates are disclosed. Visible light mediates the reaction of protected &ohgr;-modified, &agr;-unsaturated aminoalkenes (preferred) with bromine- or iodine-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface. These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.Type: ApplicationFiled: January 26, 2001Publication date: September 26, 2002Inventors: Robert J. Hamers, Wei Cai, Lloyd M. Smith, Todd C. Strother