Patents by Inventor Todd Chappell

Todd Chappell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230183712
    Abstract: Disclosed are methods, systems, components, and compositions for engineering enzymes. Particularly disclosed are methods, systems, components, and compositions for engineering phenylalanine ammonia-lyase (PAL) enzymes and isolating variant PAL enzymes with enhanced enzymatic properties. The variant PAL enzymes disclosed herein or obtained by the methods disclosed herein may be utilized for treating diseases or disorders characterized by elevated blood levels of phenylalanine, such as phenylketonuria (PKU).
    Type: Application
    Filed: February 18, 2021
    Publication date: June 15, 2023
    Inventors: Nikhil Unni Nair, Zachary Mays, Karishma Mohan, Todd Chappell, Vikas Trivedi
  • Publication number: 20070225217
    Abstract: The invention features methods, compositions, and kits for treating an immunoinflammatory disorder, an ophthalmic disorder, a musculoskeletal disorder or pain associated therewith, a periodontal disease, or a disease or condition associated with an increased serum CRP level.
    Type: Application
    Filed: November 8, 2006
    Publication date: September 27, 2007
    Applicant: CombinatoRx, Incorporated
    Inventors: Todd Chappell, Benjamin Auspitz, Edward Jost-Price
  • Publication number: 20070110685
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a non-steroidal immunophilin-dependent immunosuppressant (NsIDI) and a Group A enhancer (e.g., antifungal agent, antigout agent, anti-infective agent, antiprotozoal agent, antiviral agent, humectant, sunscreen, vitamin D compound, microtubuline inhibitor, or zinc salt) or analog or metabolite thereof to the patient. The invention also features a pharmaceutical composition containing an NsIDI and Group A enhancer or analog or metabolite thereof for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: June 16, 2006
    Publication date: May 17, 2007
    Inventors: Benjamin Auspitz, Bradley Brasher, Todd Chappell, Michael Frank, Daniel Grau, Edward Jost-Price, Seth Lederman, Palaniyandi Manivasakam, Seth Orlow, Noah Sachs, Brendan Smith
  • Publication number: 20070105761
    Abstract: The invention features methods, kits, and compositions for the treatment of ophthalmic disorders. The compositions include a corticosteroid in combination with a non-steroidal immunophilin-dependent immunosuppressant.
    Type: Application
    Filed: November 8, 2006
    Publication date: May 10, 2007
    Applicant: CombinatoRx, Incorporated
    Inventors: Todd Chappell, M. Nichols, Daniel Grau
  • Publication number: 20050192261
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient an antihistamine, either alone or in combination with one or more additional agents. The invention also features a pharmaceutical composition containing an antihistamine in combination with one or more additional agents.
    Type: Application
    Filed: September 14, 2004
    Publication date: September 1, 2005
    Inventors: Edward Jost-Price, Palaniyandi Manivasakam, Bradley Brasher, Brendan Smith, Noah Sachs, Benjamin Auspitz, Todd Chappell, Micheal Slavonic
  • Publication number: 20050153947
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: September 20, 2004
    Publication date: July 14, 2005
    Inventors: Mahesh Padval, Edward Jost-Price, Palaniyandi Manivasakam, Brendan Smith, Jason Fong, Benjamin Auspitz, M. Nichols, Curtis Keith, Grant Zimmerman, Bradley Brasher, Noah Sachs, Todd Chappell