Abstract: The methods, systems, and compositions provided herein allow improved methods for detecting non-cancer somatic mutations in a subject by measuring buffy coat somatic mutations in order to improve identification of samples with age related somatic mutations.

Abstract: Disclosed herein are modified protein disulfide isomerases (PDIs) or functional fragments thereof wherein the modified PDI or functional fragment thereof comprises a deletion of an endoplasmic reticulum (ER) signal sequence from a wild-type PDI or functional fragments thereof, and methods of making and using the same. The modified PDI or functional fragment thereof may be used to treat diseases associated with protein aggregates, including neurodegenerative diseases, muscular diseases, injuries, and aging-related conditions.

Abstract: The invention relates to monoclonal antibodies or an antigen binding fragment thereof targeting acetylation sites within the human Tau protein. K280 and K311, which can be indicative of a disease state and, as such, represent diagnostic and/or therapeutic targets. Accordingly, one aspect of the invention relates to a monoclonal antibody or an antigen binding fragment thereof that specifically binds acetylated lysine 280 or acetylated lysine 311 in human tau protein. The monoclonal antibody or an antigen binding fragment thereof can be part of a pharmaceutical composition and provided to a subject to diagnose and/or treat a tauopathy.

Abstract: Techniques for timely medication information include storing in a database, for each of multiple different medication providers, a pharmacy ID field that uniquely indicates the provider, a pharmacy link field that indicates a network link for the provider, and a pharmacy API format field that indicates a format for requesting patient medication information and for receiving patient medication information from the provider. In response to receiving, from a client process on a remote network node, a client query packet that includes a patient field that indicates information for a patient: selecting a first provider; formatting a pharmacy request packet to request medication information for the patient based on the API format field for the first provider; and, sending the first pharmacy request packet to the network link in the pharmacy link field for the first provider.

Abstract: A drain lock sealing apparatus is positioned in a drain pipe for being locked therein and further for sealing the pipe to prevent odors and vermin from coming from the drainpipe into the room. The apparatus includes a grate positioned over the drain pipe, a resiliently deformable sealing ring extending from the grate into the drainpipe, an rigid expander member with an inwardly tapered outer surface extending into the sealing ring, a resiliently deformable frusta-conical member attached to center hub of the expander member so that the peripheral closure edge of the frusta-conical member is in non-fixed normally closed relationship against the circumferential edge of the expander member so that the closure edge opens in response to liquid passing through the grate into the drain and resumes normally close relationship in response to the secession of liquid passing through the grate.

Abstract: An in-drain sealing apparatus for being positioned in a drain pipe with an interior surface where the positioning is below a surface mounted grate in a room area. The drain sealing apparatus includes a connector ring defined by a center axis, a lower edge and a peripheral surface, the connector ring positioned in the drain pipe below the grate with a first cylindrical space defined between the drain pipe interior surface and the connector ring peripheral surface. A sealing member is positioned in the first space for sealing the first cylindrical space between the peripheral surface of the connector ring and interior surface of the drain pipe for preventing access from the drain pipe to the room area through the region between the connector ring and the drain pipe.

Abstract: A handheld device for locating a foreign body in or beneath a patient's skin comprises one or more sensors that each generate a magnetic or electromagnetic field and a signal reflecting the location and/or size and/or depth of a foreign body and a processor that receives and processes each signal and generates a signal to an operatively connected display. The display that receives the display signal shows the location and/or size and/or depth of the foreign object.

Abstract: A system and method for ensuring an electronic communication sent by a user to one or more recipients is not sent to one or more inappropriate recipients. The system and method controls, monitors, detects and prevents sending of electronic communications to an unintended recipient or recipients. The system and method also controls, monitors, detects and ensures electronic communications are sent to all intended recipients. Based on parameters that identify conditions for an inappropriate recipient, the system and method compares each recipient of an electronic communication with the parameters and stops the sending if an inappropriate recipient exists. A notification is then provided identifying each inappropriate recipient and the parameters that were triggered. Mechanism to override the stopping of the electronic communication may be provided.

Abstract: A system and method for ensuring an electronic communication sent by a user to one or more recipients is not sent to one or more inappropriate recipients. The system and method controls, monitors, detects and prevents sending of electronic communications to an unintended recipient or recipients. The system and method also controls, monitors, detects and ensures electronic communications are sent to all intended recipients. Based on parameters that identify conditions for an inappropriate recipient, the system and method compares each recipient of an electronic communication with the parameters and stops the sending if an inappropriate recipient exists. A notification is then provided identifying each inappropriate recipient and the parameters that were triggered. Mechanism to override the stopping of the electronic communication may be provided.

Abstract: A system and method for ensuring compliance with National Coverage Determination Registry guidelines regarding the implantation of implantable medical devices which comprises: uploading source documentation through a computerized system to a third party evaluation; comparison of said source documentation with criteria established by the National Coverage Determination Registry (NCDR) to determine whether or not there has been compliance; and if there has been compliance, issuing approval documentation.

Abstract: Improved floor sink drain screen locks having expandable means for sealingly engaging the walls of a floor sink drain, yet being readily collapsible for quick and easy removal when desired.

Abstract: The present invention provides methods and compositions for modulating HDAC4 activity and modulating the activity of proteins downstream of HDAC4 in the muscle transcriptional pathway in a cell by modulating HDAC4 activity. Further provided are methods and compositions for treating muscle atrophy and/or inflammation by inhibiting HDAC4 activity.

Abstract: The present invention provides methods and compositions for modulating HDAC4 activity and modulating the activity of proteins downstream of HDAC4 in the muscle transcriptional pathway in a cell by modulating HDAC4 activity. Further provided are methods and compositions for treating muscle atrophy and/or inflammation by inhibiting HDAC4 activity.

Abstract: A remotely controlled insertion system for a medical device is described. The system comprises a robotic device and a remote control mechanism. The robotic device has a handle controller to receive and hold the control handle or proximal end of a medical device. The medical device is capable of moving in up to six ranges of motion. In ione embodiment a first motor is connected through a drive screw to a handle controller to move the medical device forward and backward. A second motor is connected to drive wheels effective to rotate the medical device clockwise and counter-clockwise. A third motor drives a series of gears that are connected to one or more control members on the medical device, this being effective to deflect a tip of the medical device so that movement of the third motor causes such deflection. A control unit is connected to all three motors.

Abstract: The invention provides a system and method of providing a user with specialized patient information comprising: uploading, storing, requesting, receiving, and displaying cardiological patient information for a patient. The display of the cardiological information is configured to optimal care to be provided to a patient.

Abstract: A system for monitoring a patient and treating the malfunctioning heart of the patient, either in an automatic mode or in a semiautomatic mode, includes means which derive at least one physiologic signal from or related to the patient's circulatory system representative of hemodynamic status. A feedback loop is implemented in a biventricular implant, in order to automatically or selectively optimize the patient's clinical hemodynamic status. Accordingly, the biventricular implant will be programmed to go through a series of AV delay, RV-LV timing and heart rate sequences which scan a preselected range of programmable values and apply those values to the patient's heart. Hemodynamic patient measurements will be recorded and preferably graphed over those applied values.

Abstract: A steerable catheter comprises a flexible tubular body having a proximal end, a distal end, and at least one lumen; an inflatable annular balloon positioned on or near the distal end of the tubular body; at least one electrode positioned on or near the distal end of the tubular body; and a handle attached to the proximal end of the tubular body. The handle cooperates with the distal end of the tubular body to steer the catheter. The catheter is especially useful in placing pacemaker or defibrillator leads in the heart or coronary sinus. Additionally, the invention also provides a device and platform for providing a variety of medical technologies including angiography, venography, angioplasty, stenting, valvuloplasty, embolization, drug delivery, and additional therapy delivery (e.g., laser, radiofrequency energy, ultrasound, microwave, etc).