Patents by Inventor Todd CRUMBLING

Todd CRUMBLING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220042207
    Abstract: A manufacturing process includes spinning at least one continuous poly(glycerol sebacate) (PGS)/alginate fiber from a polymeric solution comprising PGS and alginate in water, drafting the at least one continuous PGS/alginate fiber in at least one coagulation bath, and drawing the at least one continuous PGS/alginate fiber from the at least one coagulation bath. A yarn includes at least one continuous PGS fiber. A continuous poly(glycerol sebacate) (PGS)/alginate fiber forming system includes a feeding tank holding a polymeric solution of alginate and PGS, a pump, a spinneret, a first coagulation bath, a first winder, a second coagulation bath, a second winder, and a bobbin winder, the system forming at least one continuous PGS/alginate fiber from the polymeric solution of alginate and PGS.
    Type: Application
    Filed: October 21, 2021
    Publication date: February 10, 2022
    Inventors: Mevlut TASCAN, Kayla WROBLESKY, Todd CRUMBLING, Michael S. FLEMMENS
  • Publication number: 20210138109
    Abstract: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.
    Type: Application
    Filed: January 13, 2021
    Publication date: May 13, 2021
    Inventors: Stephanie REED, Carissa SMOOT, Dennis SHULL, Todd CRUMBLING, John D'OTTAVIO, Peter D. GABRIELE, Jeremy J. HARRIS, Charles Brendan NICHOLSON, Jared ELY
  • Publication number: 20210060214
    Abstract: An article includes a fibrous mat of poly(glycerol sebacate) (PGS) resin and a resin of a hydrogel forming polymer, such as a polyvinyl alcohol (PVOH). Methods of making such articles include electrospinning a combination of PGS resin and PVOH resin to form nanofibers and depositing the nanofibers onto a surface to form the fibrous mat. The mat is suitable for a variety of medical uses, including as a barrier that can be deployed in surgical procedures.
    Type: Application
    Filed: August 28, 2020
    Publication date: March 4, 2021
    Inventors: Jeremy J. HARRIS, Jared ELY, Mevlut TASCAN, Peter D. GABRIELE, Todd CRUMBLING
  • Publication number: 20200061240
    Abstract: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.
    Type: Application
    Filed: August 21, 2019
    Publication date: February 27, 2020
    Inventors: Stephanie REED, Carissa SMOOT, Dennis SHULL, Todd CRUMBLING, John D'OTTAVIO, Peter D. GABRIELE, Jeremy J. HARRIS, Charles Brendan NICHOLSON, Jared ELY
  • Publication number: 20190127887
    Abstract: A manufacturing process includes spinning at least one continuous poly(glycerol sebacate) (PGS)/alginate fiber from a polymeric solution comprising PGS and alginate in water, drafting the at least one continuous PGS/alginate fiber in at least one coagulation bath, and drawing the at least one continuous PGS/alginate fiber from the at least one coagulation bath. A yarn includes at least one continuous PGS fiber. A continuous poly(glycerol sebacate) (PGS)/alginate fiber forming system includes a feeding tank holding a polymeric solution of alginate and PGS, a pump, a spinneret, a first coagulation bath, a first winder, a second coagulation bath, a second winder, and a bobbin winder, the system forming at least one continuous PGS/alginate fiber from the polymeric solution of alginate and PGS.
    Type: Application
    Filed: November 1, 2018
    Publication date: May 2, 2019
    Inventors: Mevlut TASCAN, Kayla WROBLESKY, Todd CRUMBLING, Michael S. FLEMMENS