Abstract: A guide wire having a coil disposed over the guide wire, wherein the coil is integrally formed of a single wire and has regions of differing properties over its length. Some wire embodiments have longitudinally alternating layer segments having differing properties including radiopacity, lubricity, hydrophilicity, hemo-compatibility, flexibility, malleability, stiffness, and shape memory properties. A coil may have numerous distinct property segments, while being formed from only a single wire and requiring only two points for affixation to the guide wire.

Abstract: A guidewire manufacturing assembly and method of forming an improved distal tip on a guidewire are disclosed. A guidewire may be an elongate shaft, a coil disposed along the length of the shaft, a holding fixture coupled to the shaft, a solder ball disposed to flux, and a heat source disposed proximate the solder ball to partially melt the solder ball and allow formation of an atraumatic distal tip.

Abstract: A guide wire having a coil disposed over the guide wire, wherein the coil is integrally formed of a single wire and has regions of differing properties over its length. Some wire embodiments have longitudinally alternating layer segments having differing properties including radiopacity, lubricity, hydrophilicity, hemo-compatibility, flexibility, malleability, stiffness, and shape memory properties. A coil formed according to the present invention may have numerous distinct property segments, while being formed from only a single wire and requiring only two points for affixation to the guide wire. One wire according to the present invention is made by coating a core wire with alternating materials having different properties. Another wire has alternating layer segments including radiopaque material, such as radiopaque loaded polymer, or a radiopaque metal, bonded to the core wire.

Abstract: A guidewire manufacturing assembly and method of forming an improved distal tip on a guidewire are disclosed. A guidewire may be an elongate shaft, a coil disposed along the length of the shaft, a holding fixture coupled to the shaft, a solder ball disposed to flux, and a heat source disposed proximate the solder ball to partially melt the solder ball and allow formation of an atraumatic distal tip.