Patents by Inventor Todd D. Nelson

Todd D. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nano-suspension process
    Patent number: 9381518
    Abstract: Described herein is a process for preparing nano-suspensions, wherein the process comprises: providing an admixture of at least one active pharmaceutical compound, an aqueous dispersion medium, and milling media and applying thereto acoustic energy having a frequency of from about 10 hertz to 1000 hertz and which supplies a linear acceleration of from about 10 G's to about 100 G's (where “G” is the force of gravity) for a period sufficient to supply a nano-suspension having a D50 of less than about 1 micron, preferably less than about 500 nm. Described also are nano-suspensions having novel properties prepared via the inventive process.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: July 5, 2016
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Dennis Leung, Todd D. Nelson, Timothy A. Rhodes, Elizabeth Kwong
  • NANO-SUSPENSION PROCESS
    Publication number: 20140256818
    Abstract: Described herein is a process for preparing nano-suspensions, wherein the process comprises: providing an admixture of at least one active pharmaceutical compound, an aqueous dispersion medium, and milling media and applying thereto acoustic energy having a frequency of from about 10 hertz to 1000 hertz and which supplies a linear acceleration of from about 10 G?s to about 100 G?s (where “G” is the force of gravity) for a period sufficient to supply a nano-suspension having a D50 of less than about 1 micron, preferably less than about 500 nm. Described also are nano-suspensions having novel properties prepared via the inventive process.
    Type: Application
    Filed: October 26, 2012
    Publication date: September 11, 2014
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dennis Leung, Todd D. Nelson, Timothy A. Rhodes, Elizabeth Kwong
  • N-heterocyclic bicyclic lactone compounds
    Publication number: 20040087569
    Abstract: Novel N-heterocyclic bicyclic lactone compounds of formula I and its novel hydroxyamide precursors of formula IV, 1
    Type: Application
    Filed: October 28, 2003
    Publication date: May 6, 2004
    Inventors: Todd D. Nelson, Carl LeBlond, Michael H. Kress
  • Process of making n-heterocyclic bicyclic lactone compounds from ketoamides
    Publication number: 20040087790
    Abstract: A process of preparing a compound of Formula I 1
    Type: Application
    Filed: October 28, 2003
    Publication date: May 6, 2004
    Inventors: Todd D. Nelson, Carl LeBlond, Jeffrey V. Mitten
  • 4-Benzyl-2-hydroxy-1,4-oxazine-3-one and polymorphic forms thereof
    Patent number: 6538134
    Abstract: The present invention is concerned with 4-benzyl-2-hydroxy-1,4-oxazin-3-one, and novel processes for the preparation therof. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: March 25, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Louis S. Crocker, Karel M. Jos Brands, Todd D. Nelson, Philip J. Pye, Jonathan D. Rosen, Kai Rossen
  • 4-Benzyl-2-hydroxy-1, 4-oxazine-3-one and polymorphic forms thereof
    Publication number: 20020042510
    Abstract: The present invention is concerned with 4-benzyl-2-hydroxy-1,4-oxazin-3-one, and novel processes for the preparation therof. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.
    Type: Application
    Filed: June 8, 2001
    Publication date: April 11, 2002
    Inventors: Louis S. Crocker, Karel M. Jos Brands, Todd D. Nelson, Philip J. Pye, Jonathan D. Rosen, Kai Rossen
  • Process for the synthesis of N-benzyl-3-(4-fluorophenyl)-1-4-oxazin-2-one
    Patent number: 6177564
    Abstract: The present invention is concerned with a novel process for the preparation of N-benzyl-3-(4-fluorophenyl)-1,4-oxazin-2-one of the formula: This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity, in particular, as substance P (neurokinin-1) receptor antagonists.
    Type: Grant
    Filed: September 9, 1999
    Date of Patent: January 23, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Todd D. Nelson, Mahadevan Bhupathy
  • Vitamin D3 analogues
    Patent number: 5389622
    Abstract: A vitamin D.sub.3 analogue having at least one hydroxyalkyl substituent on the A-ring, preferably the 1-position which is useful in inhibiting cell proliferation.
    Type: Grant
    Filed: June 4, 1993
    Date of Patent: February 14, 1995
    Assignee: The John Hopkins University
    Inventors: Gary H. Posner, Todd D. Nelson
  • Vitamin D.sub.3 analogues
    Patent number: 5274142
    Abstract: A vitamin D.sub.3 analogue which includes at least one hydroxyalkyl substituent on the A-ring, preferably the 1-position thereof.
    Type: Grant
    Filed: March 12, 1992
    Date of Patent: December 28, 1993
    Assignee: The Johns Hopkins University
    Inventors: Gary H. Posner, Todd D. Nelson