Patents by Inventor Todd E. MacLaughlan

Todd E. MacLaughlan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Spironolactone and angiotensin II antagonist combination therapy for treatment of congestive heart failure
    Publication number: 20040102423
    Abstract: A combination therapy comprising a therapeutically-effective amount of an epoxy-free spirolactone-type aldosterone receptor antagonist and a therapeutically-effective amount of an angiotensin II receptor antagonist is described for treatment of circulatory disorders, including cardiovascular disorders such as hypertension, congestive heart failure, cirrhosis and ascites. Preferred angiotensin II receptor antagonists are those compounds having high potency and bioavailability and which are characterized in having an imidazole or triazole moiety attached to a biphenylmethyl or pyridinyl/phenylmethyl moiety. A preferred epoxy-free spirolactone-type aldosterone receptor antagonist is spironolactone. A preferred combination therapy includes the angiotensin II receptor antagonist 5-[2-[5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-pyridinyl]phenyl-1H-tetrazole and the aldosterone receptor antagonist spironolactone.
    Type: Application
    Filed: October 15, 2002
    Publication date: May 27, 2004
    Applicant: G.D. Searle & Co.
    Inventors: Todd E. MacLaughlan, Joseph R. Schuh
  • Use of low dose amount of aldosterone antagonist for treatment of cardiovascular disease
    Publication number: 20040097476
    Abstract: Use of low dosages of an aldosterone receptor antagonist, such as spironolactone, is described for use in treatment of circulatory disorders. This therapy would be particularly useful to treat congestive heart failure while avoiding or reducing aldosterone-antagonist-induced side effects, such as hyperkalemia.
    Type: Application
    Filed: June 30, 2003
    Publication date: May 20, 2004
    Applicant: G.D. Searle & Co.
    Inventors: Todd E. MacLaughlan, Alfonso T. Perez
  • Use of low dosage amount of spironolactone for treatment of cardiovascular disease
    Patent number: 6608047
    Abstract: Use of low dosages of an aldosterone receptor antagonist, spironolactone, is described for treatment of circulatory disorders. This therapy would be particularly useful to treat or retard the development of congestive heart failure, while avoiding or reducing aldosterone-antagonist-induced side effects, such as hyperkalemia.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: August 19, 2003
    Assignee: Pharmacia Corporation
    Inventors: Todd E. MacLaughlan, Alfonso T. Perez
  • Combination therapy of angiotensin converting enzyme inhibitor and side-effect-reduced amount of aldosterone antagonist for treatment of cardiovascular disease
    Publication number: 20030148960
    Abstract: Combinations of an ACE inhibitor and an aldosterone receptor antagonist are described for use in treatment of circulatory disorders. Of particular interest are therapies using captopril or enalapril co-administered with a low-dose of spironolactone. This co-therapy would be particularly useful to treat or prevent the progression of congestive heart failure while avoiding or reducing aldosterone-antagonist-induced side effects such as hyperkalemia.
    Type: Application
    Filed: October 4, 2002
    Publication date: August 7, 2003
    Applicant: G.D. Searle & Co.
    Inventors: Todd E. MacLaughlan, Alfonso T. Perez
  • Use of low dose amount of spironolactone for treatment of cardiovascular disease
    Publication number: 20030087884
    Abstract: Use of low dosages of an aldosterone receptor antagonist, spironolactone, is described for treatment of circulatory disorders. This therapy would be particularly useful to treat or retard the development of congestive heart failure, while avoiding or reducing aldosterone-antagonist-induced side effects, such as hyperkalemia.
    Type: Application
    Filed: January 22, 2002
    Publication date: May 8, 2003
    Applicant: G.D. Searle & Co.
    Inventors: Todd E. MacLaughlan, Alfonso T. Perez
  • Use of spironolactone for treatment of symptomatic heart failure
    Patent number: 6391867
    Abstract: Use of an aldosterone receptor antagonist, spironolactone, is described for treatment of heart failure. This therapy would be particularly useful to treat or retard the development of symptomatic heart failure, while avoiding or reducing aldosterone-antagonist-induced side effects, such as hyperkalemia.
    Type: Grant
    Filed: January 9, 2001
    Date of Patent: May 21, 2002
    Assignee: G.D. Searle & Co.
    Inventors: Todd E. MacLaughlan, Alfonso T. Perez
  • Use of low dose amount of spironolactone for treatment of cardiovascular disease
    Publication number: 20010002399
    Abstract: Use of low dosages of an aldosterone receptor antagonist, spironolactone, is described for treatment of circulatory disorders. This therapy would be particularly useful to treat or retard the development of congestive heart failure, while avoiding or reducing aldosterone-antagonist-induced side effects, such as hyperkalemia.
    Type: Application
    Filed: January 9, 2001
    Publication date: May 31, 2001
    Applicant: G.D. Searle & Co.
    Inventors: Todd E. MacLaughlan, Alfonso T. Perez