Abstract: Provided are methods for producing population of cells enriched for cells exhibiting sinoatrial node like characteristics. The cells can be produced from human pluripotent cells. Also provided are methods for using the SAN-like cells for identifying agents that can mitigate drug-induced cardiac toxicity. Also provided is a method for mitigating drug induced cardiotoxicity comprising administering to a subject an effective amount of physcion or a derivative thereof.

Abstract: Provided are compositions and methods for promoting osteogenic differentiation of undifferentiated cells, such as stem cells. An example of a compound useful in the present method is 6,8-dimethyl-3-(4-phenyl-1H-imidazol-5-yl)quinolin-2(1H)-one (DIPQUO). The present methods can be used for treatment and prevention of bone disorders.

Abstract: Provided are compositions and methods for promoting osteogenic differentiation of undifferentiated cells, such as stem cells. An example of a compound useful in the present method is 6,8-dimethyl-3-(4-phenyl-1H-imidazol-5-yl)quinolin-2(1H)-one (DIPQUO). The present methods can be used for treatment and prevention of bone disorders.

Abstract: This disclosure relates to a fluid conduit that incorporates sensors printed on an exterior wall of the fluid conduit. The sensors configured to sense an operating parameter of the fluid conduit. A protective layer is arranged to be deposited over at least selected portions of the printed electronic material.

Abstract: Described herein are devices for applying conductive gels to electrodes and the gel-laminated electrodes produced thereby. The devices permit the reuse of the electrodes by easily applying fresh gels to them for each subsequent use. In a first example embodiment, all of the components of the laminating device are provided in a single housing. In a second example embodiment, the gel applying and drive components are housed within the device, and a replaceable cartridge houses the gels and the gel delivery components. Also described herein are dispensers for storing and dispensing conductive gels that can be readily applied to and removed from an electrode.

Abstract: Described herein are devices for applying conductive gels to electrodes and the gel-laminated electrodes produced thereby. The devices permit the reuse of the electrodes by easily applying fresh gels to them for each subsequent use. In a first example embodiment, all of the components of the laminating device are provided in a single housing. In a second example embodiment, the gel applying and drive components are housed within the device, and a replaceable cartridge houses the gels and the gel delivery components. Also described herein are dispensers for storing and dispensing conductive gels that can be readily applied to and removed from an electrode.

Abstract: A drywell table includes a top frame defining at least one opening configured to receive a serving pan therethrough and a heating plate disposed below the top frame. The drywell table also includes at least two heating fins extending between the heating plate and the top frame, and defining at least one row configured to receive the pan therein, wherein heat is transferred from the heating plate and heating fins to the serving pan via a sufficiently small air gap defined between the heating plate, heating fins and the serving pan, wherein the gap minimizes convection and radiation.