Abstract: Provided are methods for treating a disease, disorder, or condition associated with an acid ceramidase (AC) biological activity. The methods include administering to a subject in need thereof a composition including an AC inhibitor and at least one additional active agent, such as a C6-ceramide nanoliposome (CNL); an inhibitor of a Bcl-2 family protein; a hypomethylating agent; an intensive chemotherapeutic agent such as cytarabine (AraC) and/or daunorubicin; a Hedgehog pathway inhibitor; a targeted agent, such as a FLT2 inhibitor or a EDH1/2 inhibitor; and/or an antibody drug conjugate that targets, for example, CD-33. The composition can include N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]2-chloroacetamide (SACLAC) or a pharmaceutically acceptable salt thereof and at least one additional active agent. The disease, disorder, or condition associated with the AC biological activity can be a cancer, such as acute myeloid leukemia (AML).

Abstract: Systems and methods of pressure testing well production equipment, such as a blowout preventer stack and a choke manifold are disclosed. The system may include a pressure testing tool disposed in selective fluid communication with the blowout preventer stack and the choke manifold and may be arranged to permit independent pressure testing of valves of the blowout preventer stack and valves of the choke manifold without breaking connections between the blowout preventer stack and the choke manifold.

Abstract: An articulating grasshopper arm includes a cable tray. The cable tray is pivotably coupled to a drilling rig by at least one pivot point. The pivot point is adapted to allow the cable tray to pivot upward and downward as well as laterally right and left relative to the drilling rig.

Abstract: According to one aspect, a drilling rig carriage is adapted to move along a drilling mast, and includes a body structure, electric motors coupled to the body structure, and pinions operably coupled to the electric motors, respectively. The pinions are adapted to engage racks, respectively. According to another aspect, a drilling mast includes a longitudinally-extending frame having a first side portion and a second side portion spaced therefrom. Racks are coupled to the frame at the first side portion thereof. According to yet another aspect, an apparatus includes a drilling mast or tower extending longitudinally along an axis, the tower including racks spaced in a parallel relation. A top drive is movable along the axis and relative to the tower. Electric motors are coupled to the top drive and movable therewith. Pinions are operably coupled to the electric motors, respectively, and engage the racks, respectively, to move the top drive.

Abstract: A BOP cart includes a platform including at least one mounting position adapted to receive the bottom of a BOP and a cart back extending generally perpendicular to the platform. The cart back includes at least one mounting feature positioned to secure the BOP to the BOP cart.

Abstract: A method that includes providing an assembled drilling rig on a first supportive surface at a first drill site, the assembled drilling rig having a walking system associated therewith, the walking system being configured to translate and rotate relative to the assembled drilling rig to displace the assembled drilling rig; actuating the walking system to lift the assembled drilling rig to a clearance height, relative to the first supportive surface; positioning a trailer under the assembled drilling rig; wherein the trailer includes a platform located above a plurality of wheels; supporting the assembled drilling rig on the trailer platform; and relocating the assembled drilling rig from the first drill site to a second drill site by rolling the wheels across the ground.

Abstract: Systems and methods of pressure testing well production equipment, such as a blowout preventer stack and a choke manifold are disclosed. The system may include a pressure testing tool disposed in selective fluid communication with the blowout preventer stack and the choke manifold and may be arranged to permit independent pressure testing of valves of the blowout preventer stack and valves of the choke manifold without breaking connections between the blowout preventer stack and the choke manifold.

Abstract: According to one aspect, a drilling rig carriage is adapted to move along a drilling mast, and includes a body structure, electric motors coupled to the body structure, and pinions operably coupled to the electric motors, respectively. The pinions are adapted to engage racks, respectively. According to another aspect, a drilling mast includes a longitudinally-extending frame having a first side portion and a second side portion spaced therefrom. Racks are coupled to the frame at the first side portion thereof. According to yet another aspect, an apparatus includes a drilling mast or tower extending longitudinally along an axis, the tower including racks spaced in a parallel relation. A top drive is movable along the axis and relative to the tower. Electric motors are coupled to the top drive and movable therewith. Pinions are operably coupled to the electric motors, respectively, and engage the racks, respectively, to move the top drive.

Abstract: Apparatuses and methods for mobile imaging and image analysis. In particular, described herein are methods and apparatuses for assisting in the acquisition and analysis of images of the tympanic membrane to provide information that may be helpful in the understanding and management of disease, such ear infection (acute otitis media). These apparatuses may guide or direct a subject in taking an image of a tympanic membrane, including automatically detecting which direction to adjust the position of the apparatus to capture an image of the tympanic membrane and automatically indicating when the tympanic membrane has been imaged.

Abstract: According to one aspect, a drilling rig carriage is adapted to move along a drilling mast, and includes a body structure, electric motors coupled to the body structure, and pinions operably coupled to the electric motors, respectively. The pinions are adapted to engage racks, respectively. According to another aspect, a drilling mast includes a longitudinally-extending frame having a first side portion and a second side portion spaced therefrom. Racks are coupled to the frame at the first side portion thereof. According to yet another aspect, an apparatus includes a drilling mast or tower extending longitudinally along an axis, the tower including racks spaced in a parallel relation. A top drive is movable along the axis and relative to the tower. Electric motors are coupled to the top drive and movable therewith. Pinions are operably coupled to the electric motors, respectively, and engage the racks, respectively, to move the top drive.

Abstract: A method that includes vertically assembling a mast having a height greater than one hundred eighty feet; securing the mast to a rig floor of a land-based drilling rig; securing a racking board adjacent the mast at a height greater than one hundred feet above the rig floor; drilling a wellbore under the rig floor with a drill string; lifting with lifting equipment coupled to the drilling mast, a stand forming a part of the drill string and having a stand length greater than one hundred feet, from a drilling position partially within the wellbore and partially above the rig floor to an in-line position above the wellbore and proximate the racking board; removing the stand from the drill string; and moving the stand, using an automated pipe handling tool, from the in-line position to a racked position so that the stand is accommodated within the racking board.

Abstract: According to one aspect, a drilling rig carriage is adapted to move along a drilling mast, and includes a body structure, electric motors coupled to the body structure, and pinions operably coupled to the electric motors, respectively. The pinions are adapted to engage racks, respectively. According to another aspect, a drilling mast includes a longitudinally-extending frame having a first side portion and a second side portion spaced therefrom. Racks are coupled to the frame at the first side portion thereof. According to yet another aspect, an apparatus includes a drilling mast or tower extending longitudinally along an axis, the tower including racks spaced in a parallel relation. A top drive is movable along the axis and relative to the tower. Electric motors are coupled to the top drive and movable therewith. Pinions are operably coupled to the electric motors, respectively, and engage the racks, respectively, to move the top drive.

Abstract: A power delivery system that includes at least one generator where the generator is positioned to provide AC power and a rectifier, where the rectifier is electrically coupled to the generator. The rectifier is positioned to convert the AC power to DC power. The power delivery system further includes an SCR, where the SCR is positioned to receive DC power from the rectifier. The SCR is adapted to selectively switch a DC motor from an off to an on position. The power delivery system also includes an inverter. The rectifier is positioned to receive DC power from the rectifier and to supply AC current to an AC motor.

Abstract: A method that includes providing an assembled drilling rig on a first supportive surface at a first drill site, the assembled drilling rig having a walking system associated therewith, the walking system being configured to translate and rotate relative to the assembled drilling rig to displace the assembled drilling rig; actuating the walking system to lift the assembled drilling rig to a clearance height, relative to the first supportive surface; positioning a trailer under the assembled drilling rig; wherein the trailer includes a platform located above a plurality of wheels; supporting the assembled drilling rig on the trailer platform; and relocating the assembled drilling rig from the first drill site to a second drill site by rolling the wheels across the ground.

Abstract: A BOP cart includes a platform including at least one mounting position adapted to receive the bottom of a BOP and a cart back extending generally perpendicular to the platform. The cart back includes at least one mounting feature positioned to secure the BOP to the BOP cart.

Abstract: Apparatuses and methods for mobile imaging and image analysis. In particular, described herein are methods and apparatuses for assisting in the acquisition and analysis of images of the tympanic membrane to provide information that may be helpful in the understanding and management of disease, such ear infection (acute otitis media). These apparatuses may guide or direct a subject in taking an image of a tympanic membrane, including automatically detecting which direction to adjust the position of the apparatus to capture an image of the tympanic membrane and automatically indicating when the tympanic membrane has been imaged.

Abstract: An apparatus for transporting a drag chain service loop comprising a frame, wherein said frame encloses the drag chain, and wherein said frame may be attached directly to a drilling rig mast while said drag chain remains enclosed therein.

Abstract: An articulating grasshopper arm includes a cable tray. The cable tray is pivotably coupled to a drilling rig by at least one pivot point. The pivot point is adapted to allow the cable tray to pivot upward and downward as well as laterally right and left relative to the drilling rig.

Abstract: An apparatus for transporting a drag chain service loop comprising a frame, wherein said frame encloses the drag chain, and wherein said frame may be attached directly to a drilling rig mast while said drag chain remains enclosed therein.

Abstract: Described herein are pharmaceutical compositions according to aspects of the present invention which include one or more hydrophilic antineoplastic chemotherapeutics, such as vinca alkyloid antineoplastic chemotherapeutics, encapsulated in ceramide anionic liposomes. Methods of treatment of a subject having cancer using the pharmaceutical compositions are described, along with methods of making ceramide anionic liposomes which encapsulate one or more hydrophilic antineoplastic chemotherapeutics in the aqueous interior of the ceramide anionic liposomes.