Abstract: Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naïve antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.

Abstract: All of a cast-iron or cast-copper stave cooler's weight is supported inside a furnace containment shell by a single gas-tight steel collar on its backside face. All the coolant piping in each cooler has every external fluid connection collected and routed together through the one steel collar. A wear protection barrier is disposed on the hot face. At least one of horizontal rows of ribs and channels retain metal inserts or refractory bricks, or pockets that assist in the retention of castable cement and/or accretions frozen in place from a melt, or an application of an area of hardfacing that is welded on in bead, crosshatch, or weave pattern.

Abstract: A plate cooler stave for use in a furnace having a shell wall, comprising: a top portion housing at least one cooling fluid inlet and at least one cooling fluid outlet for the flow of cooling fluid to and from the plate cooler stave from outside the furnace; and a main body disposed at an angle relative to the top portion so that the main body may be inserted into the furnace through an opening defined by the shell wall, wherein upon installation, at least a part of the top portion is disposed in the opening.

Abstract: A stave comprising an outer housing, an inner pipe circuit comprising individual pipes housed within the outer housing, wherein the individual pipes each has an inlet end and an outlet end and wherein each pipe may or may not be mechanically connected to another pipe, and a manifold, integral with or disposed on or in the housing; wherein the inlet and/or outlet ends of each individual pipe is disposed in or housed by the manifold. The manifold may be made of carbon steel while the housing may be made of copper. Each of the inlet and outlet ends of each individual pipe may be surrounded in part by cast copper within a housing of the manifold.

Abstract: A plate cooler stave for use in a furnace having a shell wall, comprising: a top portion housing at least one cooling fluid inlet and at least one cooling fluid outlet for the flow of cooling fluid to and from the plate cooler stave from outside the furnace; and a main body disposed at an angle relative to the top portion so that the main body may be inserted into the furnace through an opening defined by the shell wall, wherein upon installation, at least a part of the top portion is disposed in the opening.

Abstract: A stave comprising an outer housing, an inner pipe circuit comprising individual pipes housed within the outer housing, wherein the individual pipes each has an inlet end and an outlet end and wherein each pipe may or may not be mechanically connected to another pipe, and a manifold, integral with or disposed on or in the housing; wherein the inlet and/or outlet ends of each individual pipe is disposed in or housed by the manifold. The manifold may be made of carbon steel while the housing may be made of copper. Each of the inlet and outlet ends of each individual pipe may be surrounded in part by cast copper within a housing of the manifold.

Abstract: A furnace stave comprising a plurality of internal channels or conduits for circulating cooling fluid through the stave; an inlet and an outlet channel associated with each internal channel; wherein the inlet channels of two internal channels are fed by the same inlet pipe or conduit. In another preferred aspect, the inlet channels of two internal channels fed by the same inlet pipe or conduit may or may not be overlapping or in fluid communication with each other.

Abstract: A stave comprising a housing, an inner cooling fluid circuit comprising a cooling fluid inlet, a cooling fluid outlet and one or more cooling fluid pipes housed within, or cooling fluid passageways defined by, the housing, wherein each cooling fluid pipe and/or passageway is in direct or indirect fluid communication with the cooling fluid inlet and the cooling fluid outlet; and a manifold, integral with or disposed on or in the housing, that provides support for installation of the stave on a furnace shell; wherein the manifold has one or more inlet pipes, or defines one or more inlet passageways, for providing cooling fluid to the cooling fluid inlet of the cooling fluid circuit of the housing; and wherein the manifold has one or more outlet pipes, or defines one or more outlet passageways, for receiving cooling fluid from the cooling fluid outlet of the cooling fluid circuit of the housing.

Abstract: Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naive antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.

Abstract: Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naïve antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.

Abstract: A furnace stave comprising a plurality of internal channels or conduits for circulating cooling fluid through the stave; an inlet and an outlet channel associated with each internal channel; wherein the inlet channels of two internal channels are fed by the same inlet pipe or conduit. In another preferred aspect, the inlet channels of two internal channels fed by the same inlet pipe or conduit may or may not be overlapping or in fluid communication with each other.

Abstract: Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naïve antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.

Abstract: A stave comprising an outer housing, an inner pipe circuit comprising individual pipes housed within the outer housing, wherein the individual pipes each has an inlet end and an outlet end and wherein each pipe may or may not be mechanically connected to another pipe, and a manifold, integral with or disposed on or in the housing; wherein the inlet and/or outlet ends of each individual pipe is disposed in or housed by the manifold. The manifold may be made of carbon steel while the housing may be made of copper. Each of the inlet and outlet ends of each individual pipe may be surrounded in part by cast copper within a housing of the manifold.

Abstract: A distributor for a post-combustion lance, comprising: an annular member, an inner reinforcing sleeve and an outer sleeve, wherein the inner reinforcing sleeve defines a plurality of first openings and the annular member defines a plurality of second openings, wherein each of the first and second openings is in fluid communication, directly or indirectly, with a first cooling fluid passageway of the lance. Each of the first openings may be contiguous with and in direct fluid communication with one of the second openings. Additionally, the annular member may define a plurality of third openings, wherein each of the third openings is in fluid communication with a second cooling fluid passageway of the lance.

Abstract: A stave/brick construction, comprising: a stave having a plurality of ribs and a plurality of channels, wherein a front face of the stave defines a first opening into each of the channels; a plurality of bricks wherein each brick is insertable into one of the plurality of channels via its first opening to a position, upon rotation of the brick, partially disposed in the one channel such that one or more portions of the brick at least partially engage one or more surfaces of the one channel and/or of a first rib of the plurality of ribs whereby the brick is locked against removal from the one channel through its first opening via linear movement without first being rotated; and one or more wear monitors and/or thermocouples, wherein each wear monitor and thermocouple is disposed through or adjacent to the stave and/or one or more of the bricks.

Abstract: Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naïve antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.

Abstract: A frame/brick and/or a stave/brick construction, having a frame having a plurality of ribs and a plurality of channels, wherein a front face of the frame defines a first opening into each of the channels, and a plurality of bricks wherein each brick is insertable into one of the plurality of channels via its first opening to a position, upon rotation of the brick, partially disposed in the one channel such that one or more portions of the brick at least partially engage one or more surfaces of the one channel and/or of a first rib of the plurality of ribs whereby the brick is locked against removal from the one channel through its first opening via linear movement without first being rotated.

Abstract: Pipe fractures in cooling staves of blast furnaces are a common failure mechanism Herein is a repair method for a cooling stave utilized in a blast furnace, the cooling stave having a compromised stave inlet outlet pipe attached to the cooling pipe in the cooling stave, the method comprises of the steps of inserting a rigid pipe into the compromised stave inlet outlet pipe to form a first annulus; inflating a bladder disposed inside the inner pipe and cooling stave; injecting a first uncured epoxy material into the first annulus; permitting the first uncured epoxy to cure; and removing the bladder.

Abstract: A distributor for a post-combustion lance, comprising: an annular member, an inner reinforcing sleeve and an outer sleeve, wherein the annular member and the inner reinforcing sleeve may be made from different materials and the annular member and the outer sleeve each may be made from a first material. The annular member and the outer sleeve each may be made from a first material and the inner reinforcing sleeve may be made from a second material, a plurality of longitudinal ribs are spaced around an inner surface of the inner reinforcing sleeve and/or one or more of the plurality of longitudinal ribs is made of steel or other high strength material. Further, a plurality of longitudinal ribs may be spaced around an inner surface of the outer sleeve and may be made from steel or other high strength material.

Abstract: Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naïve antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.