Patents by Inventor Todd Gierahn

Todd Gierahn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10105412
    Abstract: Streptococcus pneumoniae is a major health concern, especially in very young, elderly, or immunocompromised patients. The present disclosure provides, inter alia, certain highly effective vaccines and pharmaceutical compositions in Streptococcus pneumoniae. The antigens may be used therapeutically or prophylactically.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: October 23, 2018
    Assignees: Genocea Biosciences, Inc., Chidlren's Medical Center Corporation
    Inventors: Todd Gierahn, Richard Malley
  • Patent number: 10078778
    Abstract: Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: September 18, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Viktor A. Adalsteinsson, Denis Loginov, J. Christopher Love, Alan Stockdale, Todd Gierahn
  • Patent number: 9953209
    Abstract: Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: April 24, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Viktor A. Adalsteinsson, Denis Loginov, J. Christopher Love, Alan Stockdale, Todd Gierahn
  • Patent number: 9920314
    Abstract: Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a specific antigen, CT788, which induces T-cell activation during a Chlamydia infection.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: March 20, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Darren E. Higgins, Michael N. Starnbach, Todd Gierahn, Nadia R. Roan
  • Patent number: 9873870
    Abstract: Methods and compositions for identifying antigens of human lymphocytes are provided herein.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: January 23, 2018
    Assignee: Genocea Biosciences, Inc.
    Inventors: Jessica Flechtner, Todd Gierahn
  • Publication number: 20170157234
    Abstract: Streptococcus pneumoniae is a major health concern, especially in very young, elderly, or immunocompromised patients. The present disclosure provides, inter alia, certain highly effective vaccines and pharmaceutical compositions in Streptococcus pneumoniae. The antigens may be used therapeutically or prophylactically.
    Type: Application
    Filed: June 13, 2016
    Publication date: June 8, 2017
    Inventors: Todd Gierahn, Richard Malley
  • Publication number: 20170043005
    Abstract: The present invention provides novel chlamydia antigens, nucleic acids encoding the antigens, and immunogenic compositions including the antigens. The present invention further provides methods of using the antigens to elicit immune responses (e.g., T cell-mediated and/or B cell-mediated immune responses). The present invention provides methods of prophylaxis and/or treatment of chlamydia-mediated diseases comprising administering an immunogenic composition including one or more of the novel antigens described herein.
    Type: Application
    Filed: March 24, 2016
    Publication date: February 16, 2017
    Inventors: Jessica Baker Flechtner, Kenya Prince Cohane, Todd Gierahn, Alexander Yao-Hsein Lee, George Rainer Siber
  • Publication number: 20160217315
    Abstract: Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.
    Type: Application
    Filed: March 30, 2016
    Publication date: July 28, 2016
    Inventors: Viktor A. Adalsteinsson, Denis Loginov, J. Christopher Love, Alan Stockdale, Todd Gierahn
  • Publication number: 20160209319
    Abstract: Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.
    Type: Application
    Filed: January 15, 2016
    Publication date: July 21, 2016
    Inventors: Viktor A. Adalsteinsson, Denis Loginov, J. Christopher Love, Alan Stockdale, Todd Gierahn
  • Patent number: 9393294
    Abstract: Streptococcus pneumoniae is a major health concern, especially in very young, elderly, or immunocompromized patients. The present disclosure provides, inter alia, certain highly effective vaccines and pharmaceutical compositions in Streptococcus pneumoniae. The antigens may be used therapeutically or prophylactically.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: July 19, 2016
    Assignees: Genocea Biosciences, Inc., Children's Medical Center Corporation
    Inventors: Todd Gierahn, Richard Malley
  • Publication number: 20160090589
    Abstract: Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a specific antigen, CT788, which induces T-cell activation during a Chlamydia infection.
    Type: Application
    Filed: May 6, 2015
    Publication date: March 31, 2016
    Inventors: Darren E. HIGGINS, Michael N. Starnbach, Todd Gierahn, Nadia R. Roan
  • Publication number: 20160083717
    Abstract: Methods and compositions for identifying antigens of human lymphocytes are provided herein.
    Type: Application
    Filed: April 30, 2015
    Publication date: March 24, 2016
    Inventors: Jessica Flechtner, Todd Gierahn
  • Patent number: 9051564
    Abstract: Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a specific antigen, CT788, which induces T-cell activation during a Chlamydia infection.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: June 9, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Darren E. Higgins, Michael N. Starnbach, Todd Gierahn, Nadia R. Roan
  • Patent number: 9045791
    Abstract: Methods and compositions for identifying antigens of human lymphocytes are provided herein.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: June 2, 2015
    Assignee: Genocea Biosciences, Inc.
    Inventors: Jessica Flechtner, Todd Gierahn
  • Publication number: 20140120129
    Abstract: Chlamydia antigens (e.g., polypeptides, polypeptide fragments, and fusion proteins) are provided. Also provided are vaccines and pharmaceutical compositions for treating or preventing a bacterial infection, such as Chlamydia, in a subject.
    Type: Application
    Filed: January 3, 2014
    Publication date: May 1, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Darren E. HIGGINS, Todd Gierahn
  • Patent number: 8637053
    Abstract: Chlamydia antigens (e.g., polypeptides, polypeptide fragments, and fusion proteins) are provided. Also provided are vaccines and pharmaceutical compositions for treating or preventing a bacterial infection, such as Chlamydia, in a subject.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: January 28, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: Darren E. Higgins, Todd Gierahn
  • Patent number: 8313894
    Abstract: Methods and compositions for identifying antigens of human lymphocytes are provided herein.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: November 20, 2012
    Assignee: Genocea Biosciences, Inc.
    Inventors: Jessica Flechtner, Todd Gierahn
  • Publication number: 20120189649
    Abstract: Streptococcus pneumoniae is a major health concern, especially in very young, elderly, or immunocompromised patients. The present disclosure provides, inter alia, certain highly effective vaccines and pharmaceutical compositions in Streptococcus pneumoniae. The antigens may be used therapeutically or prophylactically.
    Type: Application
    Filed: January 20, 2012
    Publication date: July 26, 2012
    Inventors: Todd Gierahn, Richard Malley
  • Publication number: 20120135025
    Abstract: The present invention provides novel chlamydia antigens, nucleic acids encoding the antigens, and immunogenic compositions including the antigens. The present invention further provides methods of using the antigens to elicit immune responses (e.g., T cell-mediated and/or B cell-mediated immune responses). The present invention provides methods of prophylaxis and/or treatment of chlamydia-mediated diseases comprising administering an immunogenic composition including one or more of the novel antigens described herein.
    Type: Application
    Filed: October 20, 2011
    Publication date: May 31, 2012
    Applicant: GENOCEA BIOSCIENCES, INC.
    Inventors: Jessica Baker Flechtner, Kenya Prince Cohane, Todd Gierahn, Alexander Yao-Hsien Lee, George Rainer Siber
  • Publication number: 20110293664
    Abstract: Disclosed are novel chlamydia antigens, nucleic acids encoding the antigens, and immunogenic compositions including the antigens. Methods of using the antigens to elicit immune responses (e.g., T cell-mediated and/or B cell-mediated immune responses) comprising administering an immunogenic composition including one or more of the novel antigens may be used for prophylaxis and/or treatment of chlamydia-mediated diseases.
    Type: Application
    Filed: December 17, 2009
    Publication date: December 1, 2011
    Applicant: GENOCEA BIOSCIENCES, INC.
    Inventors: Kenya Cohane, Michele Picard, Todd Gierahn, Jessica Flechtner