Patents by Inventor Todd H. Rider
Todd H. Rider has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9494579Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: GrantFiled: September 9, 2014Date of Patent: November 15, 2016Assignee: Massachusetts Institute of TechnologyInventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Publication number: 20160161479Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.Type: ApplicationFiled: November 11, 2014Publication date: June 9, 2016Inventors: James Douglas Harper, Richard Hart Mathews, Bernadette Johnson, Martha Susan Petrovick, Ann Rundell, Frances Ellen Nargi, Timothy Stephens, Linda Marie Mendenhall, Mark Alexander Hollis, Albert M. Young, Todd H. Rider, Eric David Schwoebel, Trina Rae Vian
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Patent number: 9005989Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.Type: GrantFiled: March 3, 2011Date of Patent: April 14, 2015Assignee: Massachusetts Institute of TechnologyInventors: James Douglas Harper, Richard Hart Mathews, Bernadette Johnson, Martha Susan Petrovick, Ann Rundell, Frances Ellen Nargi, Timothy Stephens, Linda Marie Mendenhall, Mark Alexander Hollis, Albert M. Young, Todd H. Rider, Eric David Schwoebel, Trina Rae Vian
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Publication number: 20150093745Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.Type: ApplicationFiled: November 13, 2014Publication date: April 2, 2015Inventors: James Douglas Harper, Richard Hart Mathews, Bernadette Johnson, Martha Susan Petrovick, Ann Rundell, Frances Ellen Nargi, Timothy Stephens, Linda Marie Mendenhall, Mark Alexander Hollis, Albert M. Young, Todd H. Rider, Eric David Schwoebel, Trina Rae Vian
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Publication number: 20150050723Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: ApplicationFiled: September 9, 2014Publication date: February 19, 2015Inventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Patent number: 8835127Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: GrantFiled: October 6, 2011Date of Patent: September 16, 2014Assignee: Massachusetts Institute of TechnologyInventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Publication number: 20140142026Abstract: Chimeric molecules that contain at least one pathogen-detection domain and at least one effector domain, and their methods of use in preventing or treating a pathogen infection in a cell or organism are described. The pathogen-detection domain and effector domain of the chimeric molecules are domains not typically found in nature to be associated together. Agents are also described herein having at least one pathogen-interacting molecular structure and at least one effector-mediating molecular structure, the agent being one that is non-naturally-occurring in a cell. The methods of prevention and treatment described herein are effective for a broad spectrum of pathogens and exhibit little or no toxic side-effects. Assays for the detection of a pathogen, pathogen component, or product produced or induced by a pathogen, are also provided.Type: ApplicationFiled: November 4, 2013Publication date: May 22, 2014Applicant: Massachusetts Institute of TechnologyInventor: Todd H. Rider
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Patent number: 8722347Abstract: A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the cytosol of the cell, the cell further having a emitter molecule which, in response to the increased calcium concentration in the cytosol, emits a photon; (2) a liquid medium for receiving the antigen and in which the cell is immersed; and (3) an optical detector arranged for receiving the photon emitted from the cell.Type: GrantFiled: February 27, 2009Date of Patent: May 13, 2014Assignee: Massachusetts Institute of TechnologyInventors: Todd H. Rider, Laura Bortolin
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Patent number: 8598324Abstract: Chimeric molecules that contain at least one pathogen-detection domain and at least one effector domain, and their methods of use in preventing or treating a pathogen infection in a cell or organism are described. The pathogen-detection domain and effector domain of the chimeric molecules are domains not typically found in nature to be associated together. Agents are also described herein having at least one pathogen-interacting molecular structure and at least one effector-mediating molecular structure, the agent being one that is non-naturally-occurring in a cell. The methods of prevention and treatment described herein are effective for a broad spectrum of pathogens and exhibit little or no toxic side-effects. Assays for the detection of a pathogen, pathogen component, or product produced or induced by a pathogen, are also provided.Type: GrantFiled: June 18, 2009Date of Patent: December 3, 2013Assignee: Massachusetts Institute of TechnologyInventor: Todd H. Rider
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Publication number: 20120190006Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.Type: ApplicationFiled: March 3, 2011Publication date: July 26, 2012Inventors: James Douglas Harper, Richard Hart Mathews, Bernadette Johnson, Martha Susan Petrovick, Ann Rundell, Frances Ellen Nargi, Timothy Stephens, Linda Marie Mendenhall, Mark Alexander Hollis, Albert M. Young, Todd H. Rider, Eric David Schwoebel, Trina Rae Vian
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Publication number: 20120135404Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: ApplicationFiled: October 6, 2011Publication date: May 31, 2012Applicant: Massachusetts Institute of TechnologyInventors: Eric. D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Patent number: 8067184Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: GrantFiled: July 3, 2008Date of Patent: November 29, 2011Assignee: Massachusetts Institute of TechnologyInventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Patent number: 7947509Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.Type: GrantFiled: May 7, 2007Date of Patent: May 24, 2011Assignee: Massachusetts Institute of TechnologyInventors: James Douglas Harper, Richard Hart Mathews, Bernadette Johnson, Martha Susan Petrovick, Ann Rundell, Frances Ellen Nargi, Timothy Stephens, Linda Marie Mendenhall, Mark Alexander Hollis, Albert M. Young, Todd H. Rider, Eric David Schwoebel, Trina Rae Vian
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Publication number: 20100098680Abstract: Chimeric molecules that contain at least one pathogen-detection domain and at least one effector domain, and their methods of use in preventing or treating a pathogen infection in a cell or organism are described. The pathogen-detection domain and effector domain of the chimeric molecules are domains not typically found in nature to be associated together. Agents are also described herein having at least one pathogen-interacting molecular structure and at least one effector-mediating molecular structure, the agent being one that is non-naturally-occurring in a cell. The methods of prevention and treatment described herein are effective for a broad spectrum of pathogens and exhibit little or no toxic side-effects. Assays for the detection of a pathogen, pathogen component, or product produced or induced by a pathogen, are also provided.Type: ApplicationFiled: June 18, 2009Publication date: April 22, 2010Inventor: Todd H. Rider
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Publication number: 20100041031Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: ApplicationFiled: July 3, 2008Publication date: February 18, 2010Inventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Publication number: 20100003700Abstract: A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the cytosol of the cell, the cell further having a emitter molecule which, in response to the increased calcium concentration in the cytosol, emits a photon; (2) a liquid medium for receiving the antigen and in which the cell is immersed; and (3) an optical detector arranged for receiving the photon emitted from the cell.Type: ApplicationFiled: February 27, 2009Publication date: January 7, 2010Applicant: Massachusetts Institute of TechnologyInventors: Todd H. Rider, Laura Bortolin
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Publication number: 20090221056Abstract: Methods to produce cells that remain viable at ambient or non-refrigerated temperatures, or which can be stored in a dry state are described. In particular, cell preservation is for long term storage of cells, such as mammalian cells, at ambient or non-refrigerated temperatures, while retaining cell viability. Also provided are sensor cells that can detect target particles, biological agents or other materials and which remain viable at ambient or non-refrigerated temperatures, or which can be stored in a dry state.Type: ApplicationFiled: November 30, 2006Publication date: September 3, 2009Inventors: Martha S. Petrovick, Eric D. Schwoebel, Frances E. Nargi, James D. Harper, Todd H. Rider
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Patent number: 7566694Abstract: Chimeric molecules that contain at least one pathogen-detection domain and at least one effector domain, and their methods of use in preventing or treating a pathogen infection in a cell or organism are described. The pathogen-detection domain and effector domain of the chimeric molecules are domains not typically found in nature to be associated together. Agents are also described herein having at least one pathogen-interacting molecular structure and at least one effector-mediating molecular structure, the agent being one that is non-naturally-occurring in a cell. The methods of prevention and treatment described herein are effective for a broad spectrum of pathogens and exhibit little or no toxic side-effects. Assays for the detection of a pathogen, pathogen component, or product produced or induced by a pathogen, are also provided.Type: GrantFiled: August 11, 2006Date of Patent: July 28, 2009Assignee: Massachusetts Institute of TechnologyInventor: Todd H. Rider
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Patent number: 7517660Abstract: A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the cytosol of the cell, the cell further having a emitter molecule which, in response to the increased calcium concentration in the cytosol, emits a photon; (2) a liquid medium for receiving the antigen and in which the cell is immersed; and (3) an optical detector arranged for receiving the photon emitted from the cell.Type: GrantFiled: June 19, 2006Date of Patent: April 14, 2009Assignee: Massachusetts Institute of TechnologyInventors: Todd H. Rider, Laura Bortolin
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Patent number: 7422860Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: GrantFiled: December 1, 2004Date of Patent: September 9, 2008Assignee: Massachusetts Institute of TechnologyInventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis