Abstract: Aircraft recording system configuration devices and methods are disclosed. The systems and methods provide a context-sensitive interface for rapid configuration. An aircraft recording system is operatively coupled to a data collection interface that is powered off and in an unconfigured state upon an initial installation of the aircraft recording system configuration device onboard an aircraft. A physical interface is disposed on an outer surface of the aircraft recording system configuration device, such that activating the physical interface causes an initial configuration of the aircraft recording system to be established. An indicator is further provided that disposed on the outer surface of the aircraft recording system configuration device, wherein the indicator is configured to indicate different states of the aircraft recording system.

Abstract: Techniques are disclosed for data collection in connection with one or more aircraft. Avionics inputs are received, at an avionics data collection platform, regarding a plurality of avionics parameters. The avionics parameters may be associated with components of the aircraft and collected by way of avionics sensors. The avionics parameters are aggregated by way of the data collection platform. The aggregated avionics parameters are multiplexed at the data collection platform. The multiplexed and aggregated plurality of avionics parameters are transmitted over loosely-coupled networking connections to an aircraft recording system. The aircraft recording system includes a network collector and an embedded microcontroller system. A prioritized aggregation of the avionics parameters is provided by way of the network collector and the embedded microcontroller system to external systems.

Abstract: A component for a vehicle interior may comprise a composite structure comprising a cover structure comprising a cover base, a cover layer and a cover surface; and a user interface system to present a user interface at the cover surface. The user interface system may comprise a light display and/or input device and/or actuator to provide feedback at the cover surface. The user interface may comprise the input device. The cover layer may cover at least a portion of the cover base. The cover base may comprise a core and a perimeter. The cover layer may be light-transmissive. The cover base may be opaque. The cover layer may form an illuminated border around the core. The cover layer may deform between the core and the perimeter. The cover structure may be integrally-formed. The cover layer may be molded on the cover base.

Abstract: A cleaning implement includes an implement body that receives a bar of solid hygiene product in a cavity extending through the implement body. The hygiene product is selectively movable downward to protrude through an opening among bristles or in a sponge. The implement allows for replacement of the solid hygiene product within the implement. The product may be advanced within the implement by means of a threaded rod or a helical cylinder and an abutment member. A resilient sleeve seals against water ingress while also retaining the product as it is consumed or dissolves.

Abstract: Systems, methods, and apparatus for storing perishable items under reduced pressure conditions. Total atmospheric pressure within a vacuum chamber containing a perishable item is reduced below a total pressure limit. Oxygen partial pressure and total pressure within the vacuum chamber are monitored. When oxygen partial pressure falls below a lower oxygen partial pressure limit, an oxygen-containing gas is admitted to raise oxygen partial pressure above the lower oxygen partial pressure limit. When the total atmospheric pressure reaches or exceeds the total pressure limit, total pressure is once again reduced. The vacuum container or chamber comprises a section of cylindrical pipe open at both ends, a first end cap and a second end cap, and formed of a plastic material. Notwithstanding that the pipe and end caps are formed of plastic, they are formed with a structure capable of withstanding pressure created by a high vacuum in the vacuum container.

Abstract: Systems, methods, and apparatus for storing perishable items under reduced pressure conditions. Total atmospheric pressure within a vacuum chamber containing a perishable item is reduced below a total pressure limit. Oxygen partial pressure and total pressure within the vacuum chamber are monitored. When oxygen partial pressure falls below a lower oxygen partial pressure limit, an oxygen-containing gas is admitted to raise oxygen partial pressure above the lower oxygen partial pressure limit. When the total atmospheric pressure reaches or exceeds the total pressure limit, total pressure is once again reduced. The vacuum container or chamber comprises a section of cylindrical pipe open at both ends, a first end cap and a second end cap, and formed of a plastic material. Notwithstanding that the pipe and end caps are formed of plastic, they are formed with a structure capable of withstanding pressure created by a high vacuum in the vacuum container.

Abstract: A system and method for storing perishable items under controlled atmospheric conditions is provided. Total atmospheric pressure within a vacuum chamber containing the perishable items is reduced to below a predetermined total pressure limit. Oxygen partial pressure within the chamber is monitored. When the Oxygen partial pressure falls below a predetermined lower Oxygen partial pressure limit, an Oxygen-containing gas is admitted to the vacuum chamber to raise the Oxygen partial pressure above the lower Oxygen partial pressure limit. Total atmospheric pressure within the chamber is also monitored. When the total atmospheric pressure reaches or exceed the predetermined total pressure limit, total pressure within the vacuum chamber is once again reduced below the predetermined total pressure limit.

Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

Abstract: Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [3H]-Batrachotoxin-B ([3H]-BTX-B) that binds to site 2 of a VGSC. The molecules of the invention comprise a moiety which increases the binding affinity of molecules for the protein binding site in prostate cancer cells (PCs), and which is also fluorescent. In one embodiment the invention molecules are an inhibition system that can be used to target over-abundant or hyperactive VGSCs selectively in pain, epilepsy or prostate cancer, inhibiting the proliferation of PCs. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.

Abstract: Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [3H]-Batrachotoxin-B ([3H]-BTX-B) that binds to site 2 of a VGSC. The molecules of the invention comprise a moiety which increases the binding affinity of molecules for the protein binding site in prostate cancer cells (PCs), and which is also fluorescent. In one embodiment the invention molecules are an inhibition system that can be used to target over-abundant or hyperactive VGSCs selectively in pain, epilepsy or prostate cancer, inhibiting the proliferation of PCs. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.

Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Abstract: A Composite Pattern with BLOB data types is used to model a hierarchical network, and includes a path-like construct for locating each component within the network model. Database procedures are used to efficiently search, modify and retrieve individual nodes from the network model using the database server's memory pool so that client applications are not required to retrieve and deserialize the entire Composite-BLOB hierarchy in order to make modifications or search for individual elements, thereby substantially reducing the transfer of data between the application layer and database. To avoid the need for dynamic memory restructuring during deserialization, the size required to store component data at each composite is stored when the composite is serialized, and during deserialization, the size is retrieved and used to obtain sufficient memory for the deserialized composite.

Abstract: The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.

Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Abstract: The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.

Abstract: A tray is assembled by automated equipment from a die cut blank. Tabs on opposing ends of side pieces are enfolded in rolled ends. A serrated edge on a distal edge of each rolled end is placed into a slit and crushed area to interlock the distal edge with the blank and form a tray with interlocked walls. The serrated edge does not penetrate the die cut blank, thus providing a leakproof, interlocked tray. Perforations define various fold lines to facilitate the use of automated equipment to form the tray. Release paper is placed on the central portion of the tray, with cake batter placed on the release paper. The batter can be baked into a cake while still in the tray.