Abstract: A cleaning implement includes an implement body that receives a bar of solid hygiene product in a cavity extending through the implement body. The hygiene product is selectively movable downward to protrude through an opening among bristles or in a sponge. The implement allows for replacement of the solid hygiene product within the implement. The product may be advanced within the implement by means of a threaded rod or a helical cylinder and an abutment member. A resilient sleeve seals against water ingress while also retaining the product as it is consumed or dissolves.

Abstract: Systems, methods, and apparatus for storing perishable items under reduced pressure conditions. Total atmospheric pressure within a vacuum chamber containing a perishable item is reduced below a total pressure limit. Oxygen partial pressure and total pressure within the vacuum chamber are monitored. When oxygen partial pressure falls below a lower oxygen partial pressure limit, an oxygen-containing gas is admitted to raise oxygen partial pressure above the lower oxygen partial pressure limit. When the total atmospheric pressure reaches or exceeds the total pressure limit, total pressure is once again reduced. The vacuum container or chamber comprises a section of cylindrical pipe open at both ends, a first end cap and a second end cap, and formed of a plastic material. Notwithstanding that the pipe and end caps are formed of plastic, they are formed with a structure capable of withstanding pressure created by a high vacuum in the vacuum container.

Abstract: Systems, methods, and apparatus for storing perishable items under reduced pressure conditions. Total atmospheric pressure within a vacuum chamber containing a perishable item is reduced below a total pressure limit. Oxygen partial pressure and total pressure within the vacuum chamber are monitored. When oxygen partial pressure falls below a lower oxygen partial pressure limit, an oxygen-containing gas is admitted to raise oxygen partial pressure above the lower oxygen partial pressure limit. When the total atmospheric pressure reaches or exceeds the total pressure limit, total pressure is once again reduced. The vacuum container or chamber comprises a section of cylindrical pipe open at both ends, a first end cap and a second end cap, and formed of a plastic material. Notwithstanding that the pipe and end caps are formed of plastic, they are formed with a structure capable of withstanding pressure created by a high vacuum in the vacuum container.

Abstract: A system and method for storing perishable items under controlled atmospheric conditions is provided. Total atmospheric pressure within a vacuum chamber containing the perishable items is reduced to below a predetermined total pressure limit. Oxygen partial pressure within the chamber is monitored. When the Oxygen partial pressure falls below a predetermined lower Oxygen partial pressure limit, an Oxygen-containing gas is admitted to the vacuum chamber to raise the Oxygen partial pressure above the lower Oxygen partial pressure limit. Total atmospheric pressure within the chamber is also monitored. When the total atmospheric pressure reaches or exceed the predetermined total pressure limit, total pressure within the vacuum chamber is once again reduced below the predetermined total pressure limit.

Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

Abstract: Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [3H]-Batrachotoxin-B ([3H]-BTX-B) that binds to site 2 of a VGSC. The molecules of the invention comprise a moiety which increases the binding affinity of molecules for the protein binding site in prostate cancer cells (PCs), and which is also fluorescent. In one embodiment the invention molecules are an inhibition system that can be used to target over-abundant or hyperactive VGSCs selectively in pain, epilepsy or prostate cancer, inhibiting the proliferation of PCs. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.

Abstract: Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [3H]-Batrachotoxin-B ([3H]-BTX-B) that binds to site 2 of a VGSC. The molecules of the invention comprise a moiety which increases the binding affinity of molecules for the protein binding site in prostate cancer cells (PCs), and which is also fluorescent. In one embodiment the invention molecules are an inhibition system that can be used to target over-abundant or hyperactive VGSCs selectively in pain, epilepsy or prostate cancer, inhibiting the proliferation of PCs. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.

Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Abstract: A Composite Pattern with BLOB data types is used to model a hierarchical network, and includes a path-like construct for locating each component within the network model. Database procedures are used to efficiently search, modify and retrieve individual nodes from the network model using the database server's memory pool so that client applications are not required to retrieve and deserialize the entire Composite-BLOB hierarchy in order to make modifications or search for individual elements, thereby substantially reducing the transfer of data between the application layer and database. To avoid the need for dynamic memory restructuring during deserialization, the size required to store component data at each composite is stored when the composite is serialized, and during deserialization, the size is retrieved and used to obtain sufficient memory for the deserialized composite.

Abstract: The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.

Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Abstract: The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.