Abstract: A system for delivering an implant device to a vascular site in a patient a delivery pusher apparatus, an implant device detachably connected to the delivery pusher apparatus by a tether having a distal end connected to a proximal end of the implant device, wherein the tether is substantially non-tensioned when connecting the implant device to the delivery pusher, and an electrical heating element configured coaxially around at least a portion of the tether, wherein heat generated by the heating element severs the tether at a point near the proximal end of the implant device.

Abstract: Methods for treating a cerebral aneurysm may include advancing a resilient self-expanding implant coupled to a pusher within a microcatheter to the cerebral aneurysm within the patient's vasculature. The implant may include a permeable shell, a coil extending from a distal end of the permeable shell, and a bioactive agent. The implant may be deployed within the cerebral aneurysm, where the coil and the permeable shell each assume an expanded deployed configuration. In an expanded deployed configuration, the coil has at least one loop having a secondary diameter and the permeable shell has an axially shortened configuration relative to a radially constrained elongated configuration.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include coils, stiffening elements, or reinforcement elements disposed about or associated with the filaments or woven together with the filaments.

Abstract: Devices for treating a cerebral aneurysm may include proximal and distal self-expanding resilient permeable shells each including a plurality of elongate resilient filaments having a braided structure. The distal permeable shell may include a first plurality of filaments gathered at least at the proximal end thereof. The proximal permeable shell may include a second plurality of filaments are gathered at least at the proximal end thereof. The expanded state of the distal permeable shell may have a convex shape at the distal end of the distal permeable shell and the expanded state of the proximal permeable shell may have a generally convex shape at the proximal end of the proximal permeable shell. The expanded states of the distal and proximal permeable shells may also define a toroidal cavity through which an elongate support member extends.

Abstract: Devices and methods for treatment of a patient's vasculature are described. The device includes a self-expanding permeable implant having a radially constrained state and an expanded state with a shortened configuration, a plurality of elongate filaments which are woven together in a tubular braid, and a fixation element. The fixation element may be a hook, barb, protrusion, bioadhesive, or pore. The implant includes at least some nitinol filaments and at least some composite filaments. Methods of treating a cerebral aneurysm are also described. The methods include advancing a permeable implant to the aneurysm, deploying the implant, and delivering embolic material into the cerebral aneurysm adjacent a portion of the permeable implant that spans the neck.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant made from a plurality of elongate filaments that are woven together. The implant may have a first unrestrained preset configuration comprising a dome portion and a brim portion, having a distal end with an outer surface having a convex shape. The implant may have a second deployed configuration that is an inversion of the first unrestrained configuration. The second deployed configuration has an open distal end and has an inner surface having a concave shape.

Abstract: Devices and methods for treatment of a patient's vasculature are described. The device includes a self-expanding resilient permeable shell having a radially constrained state and an expanded state with a globular, axially shortened configuration. The permeable shell may be a single layer of braided elongate filaments having first and second ends that are secured at the proximal end of the permeable shell. The devices may also include permeable shells made of woven braided mesh having a variable mesh density, i.e., the average size of pores in one region are a different than the average size of pores in another region. Methods of using the device to treat a cerebral aneurysm are also described. Methods of forming a tubular braid are also described. Methods of forming a tubular braid with variable braid densities are described. Methods of forming a tubular braid using a castellated mandrel are also described.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include coils, stiffening elements, or reinforcement elements disposed about or associated with the filaments or woven together with the filaments.

Abstract: An embolic coil having a stretch resistant member for resisting stretching or unwinding of the embolic coil. A tubular member may be attached to a proximal end of the embolic coil. A stretch resistant member may extend through the tubular member and the embolic coil to be attached at its distal end to the embolic coil. The stretch resistant member may include an enlargement to prevent the stretch resistant member from withdrawing into the tubular member. The stretch resistant member may comprise a one-piece design comprising a tether or a two-piece design comprising a tether in combination with another component such as a filament, a braid, or an eyelet. The stretch resistant member may be wavy to allow slack. The distal end of the stretch resistant member may be attached to the embolic coil by tying a knot, melting into a tip, or the use of adhesives, welding, or soldering.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant connected to an expandable stent through a plurality of wires. The permeable shell is configured for placement in an aneurysm and the expandable stent is configured for placement in a parent vessel proximal, near, or adjacent the aneurysm.

Abstract: A system for delivering an implant device to a vascular site in a patient a delivery pusher apparatus, an implant device detachably connected to the delivery pusher apparatus by a tether having a distal end connected to a proximal end of the implant device, wherein the tether is substantially non-tensioned when connecting the implant device to the delivery pusher, and an electrical heating element configured coaxially around at least a portion of the tether, wherein heat generated by the heating element severs the tether at a point near the proximal end of the implant device.

Abstract: A system for delivering an implant device to a vascular site in a patient a delivery pusher apparatus, an implant device detachably connected to the delivery pusher apparatus by a tether having a distal end connected to a proximal end of the implant device, wherein the tether is substantially non-tensioned when connecting the implant device to the delivery pusher, and an electrical heating element configured coaxially around at least a portion of the tether, wherein heat generated by the heating element severs the tether at a point near the proximal end of the implant device.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a first permeable shell and a second permeable shell, where the second permeable shell sits within an interior cavity of the first permeable shell. The first and second permeable shells may each be made from a plurality of elongate filaments that are woven together to form a mesh. The mesh of the first permeable shell may have a larger mesh density and be softer than the mesh of the second permeable shell.

Abstract: Methods and devices for treating a cerebral aneurysm are described. The device may include proximal and distal self-expanding resilient permeable shells each including a plurality of elongate resilient filaments having a braided structure. The distal permeable shell may include a first plurality of filaments gathered at least at the proximal end thereof. The proximal permeable shell may include a second plurality of filaments are gathered at least at the proximal end thereof. The expanded state of the distal permeable shell may have a convex shape at the distal end of the distal permeable shell and the expanded state of the proximal permeable shell may have a generally convex shape at the proximal end of the proximal permeable shell. The expanded states of the distal and proximal permeable shells may also define a toroidal cavity through which an elongate support member extends.

Abstract: Devices and methods for treatment of a patient's vasculature may include a resilient self-expanding permeable implant having a radially constrained elongated state configured for delivery within a catheter lumen and an expanded state with a longitudinally shortened configuration, and a plurality of elongate filaments which are woven together. Each of the plurality of elongate filaments may have a diameter between about 0.0005 and about 0.005 inches. The implant includes at least some filaments consisting of nitinol and at least some composite filaments that are drawn filled tube wires comprising an external nitinol tube and a highly radiopaque material concentrically disposed within the external tube. The implant has at least about 40% composite filaments relative to a total number of filaments, and wherein a total number of filaments is about 10 to about 300.

Abstract: Methods and devices for treating a cerebral aneurysm utilize a device that includes a self-expanding resilient permeable shell made from elongate resilient filaments. At least some of the filaments have a distal region that extends beyond the distal end of the permeable shell and form an extension having a generally circular shape when expanded. The permeable shell has a radially constrained elongated state configured for delivery within a microcatheter and has an expanded state with a globular, axially shortened configuration. The permeable shell has a plurality of openings formed between the braided filaments. The distal regions of the plurality of filaments that form the extension may be braided, partially braided, or unraveled. Once deployed within the cerebral aneurysm, the extension may be positioned near a dome of the cerebral aneurysm.

Abstract: Devices and methods for treatment of a patient’s vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include coils, stiffening elements, or reinforcement elements disposed about or associated with the filaments or woven together with the filaments.

Abstract: Devices and methods for treatment of a patient’s vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The implant may include a cavity in a proximal section that may optionally house embolic material, such as coils. Alternatively, the implant may have an expanded preset shape that is different than an expanded preset shape that is assumed after deployment in an aneurysm. The expanded preset shape may be frustoconical. Alternatively, the implant may include an outer skirt coupled to a proximal section of the permeable implant.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include coils, stiffening elements, or reinforcement elements disposed about or associated with the filaments or woven together with the filaments.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include an implant having multiple mesh layers. A first and second layer of the implant may be formed by folding over a single mesh and the third layer may be formed from a different mesh. The first, second, and third layers may be either a stasis or a structural layer and may be arranged in different orders. Embodiments may also include structures to assist in the expansion of the device. These structures may include an expandable loop or reinforcing finger extensions. Embodiments may also include a corrugation or ridge around a middle section of the implant to assist in deployment.