Abstract: The disclosure relates to an in situ-gelling hydrogel composition based on functionalized zwitterionic polymers. The resulting hydrogels exhibit highly anti-fouling, anti-adhesive, and lubricating properties to enable the fabrication of bulk hydrogels or hydrogel-based coatings of relevance to biomedical applications.

Abstract: Described herein is a zwitterionic polymer-based coating that, when applied to an electrochemical biosensor, is capable of reducing fouling without compromising the current signal while also facilitating probe attachment.

Abstract: This disclosure relates to magnetic microgel beads, and in particular to magnetic microgel beads for biofunctionalization and methods of making and uses thereof, for example, in biosensing assays. In an embodiment, a magnetic microparticle comprising a magnetic nanoparticle encapsulated by a polymer hydrogel. In another embodiment, an assay for detecting the presence of a target analyte in a sample comprising a) the magnetic microparticle disclosed herein, wherein the biorecognition agent further comprises a reporter moiety; b) an electrochemical chip comprising a working electrode, a counter electrode and a reference electrode; and c) a capture probe functionalized on the working electrode; wherein binding of the biorecognition agent to the target analyte results in production of an electrochemical, electroluminescent or photoelectrochemical signal.

Abstract: The disclosure relates to an in situ-gelling hydrogel composition based on functionalized zwitterionic polymers. The resulting hydrogels exhibit highly anti-fouling, anti-adhesive, and lubricating properties to enable the fabrication of bulk hydrogels or hydrogel-based coatings of relevance to biomedical applications.

Abstract: This specification describes the modification of starch-based nanoparticles (SNPs) by introducing one or more reactive chemical groups onto the surface of SNPs. In some examples, the SNPs are hydrophobic and have a size in the range of 10-50 nm. The SNPs may be adapted for the delivery of agrochemical agents to plants. The SNPs created herein are attractive since they are generated from a sustainable source and are generally regarded as safe (GRAS) in terms of their degradation products once they break down. In some examples, the SNPs are based on SNPs produced by existing industrial-scale production.

Abstract: The present application relates to a vehicle whose shell material is modified with at least one additional secondary phase that acts as a cork. In the presence of an energy source (preferably ultrasound), the corks embedded in the shell are either removed from the shell to create permanent pores or perturbed within the shell to create transient pores that can control transport in or out of the vehicle.

Abstract: The disclosure relates to an in situ-gelling hydrogel composition based on functionalized zwitterionic polymers. The resulting hydrogels exhibit highly anti-fouling, anti-adhesive, and lubricating properties to enable the fabrication of bulk hydrogels or hydrogel-based coatings of relevance to biomedical applications.

Abstract: The present application relates to a biosensor for detecting an analyte comprising a first and second working electrode; a detection probe functionalized on the first working electrode, the detection probe comprising a reporter moiety and a recognition moiety for an analyte; a capture probe functionalized on the second working electrode; and a counter electrode. Each working electrode is configured to provide a change in signal if the analyte is present. The biosensor can be used to detect an analyte in a sample.

Abstract: The present application relates to in situ gelling hydrogel structures formed by the crosslinking of polysaccharide-based nanoparticles and functional polymers. Such systems can be designed to release the nanoparticles and/or encapsulated therapeutics either over time or in response to environmental stimuli.

Abstract: The present application relates to a vehicle whose shell material is modified with at least one additional secondary phase that acts as a cork. In the presence of an energy source (preferably ultrasound), the corks embedded in the shell are either removed from the shell to create permanent pores or perturbed within the shell to create transient pores that can control transport in or out of the vehicle.

Abstract: The present application relates to brush amphiphilic block copolymers comprising at least one block which is hydrophilic and at least another block which is hydrophobic.

Abstract: The invention pertains to a printable hydrogel that can both immobilize and stabilize a wide range of biomolecules and/or cells on a substrate while restricting the access of surrounding chemicals to the biomolecule active site. Such hydrogels can be adapted to high-throughput screening applications and can discriminate between true inhibitors and promiscuous aggregating inhibitors as well as enable the determination of dose-response relationships of biomolecule and/or cell inhibitory chemicals with high accuracy.

Abstract: The present application relates to hydrogel compositions comprising first and second precursor polymers, wherein the precursor polymers are modified poly(oligoethylene glycol methacrylate) copolymers that are crosslinked through electrophile-nucleophile reactions.

Abstract: The present application relates to hydrogel compositions comprising first and second precursor polymers, wherein the precursor polymers are modified poly(oligoethylene glycol methacrylate) copolymers that are crosslinked through electrophile-nucleophile reactions.

Abstract: The present application relates to brush amphiphilic block copolymers comprising at least one block which is hydrophilic and at least another block which is hydrophobic.

Abstract: The present application relates to hydrogel compositions comprising first and second precursor polymers, wherein the precursor polymers are modified poly(oligoethylene glycol methacrylate) copolymers that are crosslinked through electrophile-nucleophile reactions.

Abstract: The present application relates to an aqueous method for the preparation of microgel particles using a stimuli-responsive prepolymer