Patents by Inventor Todd Holmes

Todd Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20260091246
    Abstract: A computer-implemented method of performing a quality assurance (QA) test on a treatment delivery system is disclosed. The method includes generating a beam plan template for performing the QA test on the treatment delivery system, wherein the beam plan template is based on a testing guideline for the QA test, in response to a first user input, determining, with the one or more processors, one or more system-specific capabilities of the treatment delivery system at the time of receipt of the first user input, generating a QA beam plan for performing the QA test on the treatment delivery system, wherein the QA beam plan is based on the beam plan template and the one or more system-specific capabilities of the treatment delivery system, and causing the treatment delivery system to perform the QA beam plan.
    Type: Application
    Filed: November 12, 2024
    Publication date: April 2, 2026
    Applicant: VARIAN MEDICAL SYSTEMS, INC.
    Inventors: Todd HOLMES, Sebastijan MÜLLER, Silvio PFLUGI
  • Patent number: 12508447
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: December 30, 2025
    Assignees: VARIAN MEDICAL SYSTEMS, INC., SIEMENS HEALTHINEERS INTERNATIONAL AG
    Inventors: Christof Baltes, Todd Holmes
  • Publication number: 20240001152
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Application
    Filed: September 14, 2023
    Publication date: January 4, 2024
    Inventors: Christof BALTES, Todd HOLMES
  • Patent number: 11786758
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: October 17, 2023
    Assignees: SIEMENS HEALTHINEERS INTERNATIONAL AG, VARIAN MEDICAL SYSTEMS, INC.
    Inventors: Christof Baltes, Todd Holmes
  • Publication number: 20210283427
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Application
    Filed: May 26, 2021
    Publication date: September 16, 2021
    Inventors: Christof BALTES, Todd HOLMES
  • Patent number: 11090512
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: August 17, 2021
    Assignees: VARIAN MEDICAL SYSTEMS, INC., VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
    Inventors: Christof Baltes, Todd Holmes
  • Publication number: 20200238103
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Application
    Filed: April 10, 2020
    Publication date: July 30, 2020
    Inventors: Christof BALTES, Todd HOLMES
  • Patent number: 10682527
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: June 16, 2020
    Assignees: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG, VARIAN MEDICAL SYSTEMS, INC.
    Inventors: Christof Baltes, Todd Holmes
  • Publication number: 20190160308
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Application
    Filed: January 16, 2019
    Publication date: May 30, 2019
    Inventors: Christof BALTES, Todd HOLMES
  • Patent number: 10286229
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: May 14, 2019
    Assignees: VARIAN MEDICAL SYSTEMS, INC., VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
    Inventors: Christof Baltes, Todd Holmes
  • Publication number: 20160136460
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Application
    Filed: January 21, 2016
    Publication date: May 19, 2016
    Inventors: Christof BALTES, Todd HOLMES
  • Patent number: 9265971
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: February 23, 2016
    Assignees: Varian Medical Systems, Inc., Varian Medical Systems International AG
    Inventors: Christof Baltes, Todd Holmes
  • Publication number: 20150224342
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Application
    Filed: February 7, 2014
    Publication date: August 13, 2015
    Applicants: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG, VARIAN MEDICAL SYSTEMS, INC.
    Inventors: Christof BALTES, Todd HOLMES
  • Publication number: 20070190603
    Abstract: Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic.
    Type: Application
    Filed: August 29, 2006
    Publication date: August 16, 2007
    Inventors: Todd Holmes, Shuguang Zhang, Alexander Rich, C. DiPersio, Curtis Lockshin
  • Patent number: 7098028
    Abstract: Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: August 29, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Todd Holmes, Shuguang Zhang, Alexander Rich, C. Michael DiPersio, Curtis Lockshin
  • Patent number: 6800481
    Abstract: Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic.
    Type: Grant
    Filed: March 26, 1997
    Date of Patent: October 5, 2004
    Assignee: Massachusetts Institute of Technology
    Inventors: Todd Holmes, Shuguang Zhang, Alexander Rich, C. Michael DiPersio, Curtis Lockshin
  • Publication number: 20040087013
    Abstract: Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic.
    Type: Application
    Filed: March 17, 2003
    Publication date: May 6, 2004
    Inventors: Todd Holmes, Shuguang Zhang, Alexander Rich, C. Michael DiPersio, Curtis Lockshin
  • Patent number: 6548630
    Abstract: Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: April 15, 2003
    Assignee: Massachusettes Insitute of Technology
    Inventors: Shuguang Zhang, Curtis Lockshin, Alexander Rich, Todd Holmes
  • Patent number: 5955343
    Abstract: Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK).sub.2 (ARARADAD).sub.2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: September 21, 1999
    Assignee: Massachusetts Institute of Technology
    Inventors: Todd Holmes, Shuguang Zhang, Alexander Rich, C. Michael DiPersio, Curtis Lockshin
  • Patent number: 5670483
    Abstract: Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK).sub.2 (ARARADAD).sub.2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: September 23, 1997
    Assignee: Massachusetts Insititute of Technology
    Inventors: Shuguang Zhang, Curtis Lockshin, Alexander Rich, Todd Holmes