Abstract: Various embodiments provide a synuclein signature for distinguishing multiple system atrophy (MSA) from Parkinson's disease (PD) in a patient, the synuclein signature comprises a quantitation of total P-SYN across a posterior cervical biopsy site, a distal thigh biopsy site, and a distal leg biopsy site, and a distribution coefficient of P-SYN across the posterior cervical biopsy site, the distal thigh biopsy site, and the distal leg biopsy site.

Abstract: Various embodiments provide a multi-faceted algorithm tool would impact the burden of disease through improvements to clinical practice and by hastening the development of novel therapeutic treatments. In addition, the multi-faceted algorithm tool provides evidence of target engagement in clinical trials and accelerates progress towards disease modification.

Abstract: Methods and compounds are described that allow partitioning of messenger RNAs encoding runctionally related proteins, in particular those involved in cellular growth and differentiation, based upon binding to target sequences in the untranslated portions of the RNAS. The preparation of mRNA-subset libraries containing genes encoding such growth regulatory factors is described together with novel gene sequences derived useing these mRNA partitioning methods. These methods of mRNA partitioning allow access to growth regulatory factors unique to a given cell, tissue or tumor and provide a method of fingerprinting such factors.

Abstract: A peptide, Hel-N1, which can bind to a 3'-untranslated mRNA sequence (which encompasses the "instability sequence") that is uniquely present in the messenger RNAs that encode oncoproteins and lymphokines, and mediates the specific destruction of the messenger RNAs, is described. Full-length Hel-N1 is capable of suppressing cell growth and causing cellular differentiation. Hel-N1 possess three RNA recognition motifs. One of these forms an RNA-binding domain which, when transfected alone into cells, causes them to undergo rapid growth.

Abstract: Methods and compounds are described that allow partitioning of messenger RNAs encoding runctionally related proteins, in particular those involved in cellular growth and differentiation, based upon binding to target sequences in the untranslated portions of the RNAs. The preparation of mRNA-subset libraries containing genes encoding such growth regulatory factors is described together with novel gene sequences derived useing these mRNA partitioning methods. These methods of mRNA partitioning allow access to growth regulatory factors unique to a given cell, tissue or tumor and provide a method of fingerprinting such factors.